期刊
MEDICINA-LITHUANIA
卷 58, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/medicina58111553
关键词
ATL; HAM; TSP; neurological manifestations; CNS involvement; neurolymphomatosis; infection
ATL is a rare but highly aggressive T-cell neoplasm associated with HTLV-1 infection, characterized by a range of neurological symptoms. This review emphasizes the importance of a multidisciplinary approach in managing the neurological symptoms of ATL patients.
ATL is a rare but a highly aggressive T-cell neoplasm associated with human T-cell leukemia virus-1 (HTLV-1) infection. Human T-cell lymphotropic virus type-1 (HTLV-1) is a oncogenic retrovirus responsible for the development of adult T-cell leukemia (ATL), but also for other non-malignant diseases, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 has a higher prevalence in Japan, the Caribbean, South America, intertropical Africa, Romania, and northern Iran. ATL patients can have an extensive spectrum of neurological manifestations. Numerous factors can be implicated, such as central nervous system infiltrates, neurolymphomatosis, complications to medication or allogeneic stem cell transplantation, HAM/TSP, infections, metabolic disturbances. The neurological complications are not always easy to recognize and treat. Thus, this review underlines the necessity of a multidisciplinary approach in ATL patients with neurological symptomatology.
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