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CLINICAL CANCER RESEARCH (2012)
Withdrawal of Essential Amino Acids Increases Autophagy by a Pathway Involving Ca2+/Calmodulin-dependent Kinase Kinase-β (CaMKK-β)
Ghita Ghislat et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Atg9 vesicles are an important membrane source during early steps of autophagosome formation
Hayashi Yamamoto et al.
JOURNAL OF CELL BIOLOGY (2012)
Major Response to Everolimus in Melanoma With Acquired Imatinib Resistance
Lu Si et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Hyperactivation of mTOR critically regulates abnormal osteoclastogenesis in neurofibromatosis type 1
Junrong Ma et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2012)
The mTOR Pathway in Lung Cancer and Implications for Therapy and Biomarker Analysis
Simon Ekman et al.
JOURNAL OF THORACIC ONCOLOGY (2012)
Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling
Shubham Shrivastava et al.
JOURNAL OF VIROLOGY (2012)
Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation
Y. Bian et al.
ONCOGENE (2012)
The emerging role of mTORC1 signaling in placental nutrient-sensing
T. Jansson et al.
PLACENTA (2012)
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling
Chongben Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Charting the Landscape of Tandem BRCT Domain-Mediated Protein Interactions
Nicholas T. Woods et al.
SCIENCE SIGNALING (2012)
mTOR, linking metabolism and immunity
Xiaojin Xu et al.
SEMINARS IN IMMUNOLOGY (2012)
mTOR and metabolic pathways in T cell quiescence and functional activation
Kai Yang et al.
SEMINARS IN IMMUNOLOGY (2012)
Vaccines for Melanoma and Renal Cell Carcinoma
Howard L. Kaufman
SEMINARS IN ONCOLOGY (2012)
Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response.
James A. McCubrey et al.
ONCOTARGET (2012)
PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ
Yutaka Kurebayashi et al.
CELL REPORTS (2012)
Overcoming breast cancer drug resistance with mTOR inhibitors. Could it be a myth or a real possibility in the short-term future?
Nadia Margariti et al.
BREAST CANCER RESEARCH AND TREATMENT (2011)
Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines
Y. Wang et al.
BRITISH JOURNAL OF CANCER (2011)
mTOR Kinase Inhibitor AZD8055 Enhances the Immunotherapeutic Activity of an Agonist CD40 Antibody in Cancer Treatment
Qun Jiang et al.
CANCER RESEARCH (2011)
mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
Pat Gulhati et al.
CANCER RESEARCH (2011)
High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1
Paige Yellen et al.
CELL CYCLE (2011)
mTOR signaling in protein homeostasis Less is more?
Crystal S. Conn et al.
CELL CYCLE (2011)
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
Ruoning Wang et al.
IMMUNITY (2011)
Alkaline Stress-Induced Autophagy is Mediated by mTORC1 Inactivation
Jinkyu Suk et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2011)
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
Greg M. Delgoffe et al.
NATURE IMMUNOLOGY (2011)
Rapamycin passes the torch: a new generation of mTOR inhibitors
Don Benjamin et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer
Jatin Roper et al.
PLOS ONE (2011)
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Qian Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Bevacizumab and Everolimus in the Treatment of Patients With Metastatic Melanoma
John D. Hainsworth et al.
CANCER (2010)
Activation of mTOR signaling pathway contributes to survival of cervical cancer cells
Jing Ji et al.
GYNECOLOGIC ONCOLOGY (2010)
EphA2 Mutation in Lung Squamous Cell Carcinoma Promotes Increased Cell Survival, Cell Invasion, Focal Adhesions, and Mammalian Target of Rapamycin Activation
Leonardo Faoro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo
Didier Roulin et al.
MOLECULAR CANCER (2010)
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
Weiming Ouyang et al.
NATURE IMMUNOLOGY (2010)
Immune Checkpoint Proteins: A New Therapeutic Paradigm for Cancer-Preclinical Background: CTLA-4 and PD-1 Blockade
Jeffrey Weber
SEMINARS IN ONCOLOGY (2010)
Why do viruses cause cancer? Highlights of the first century of human tumour virology
Patrick S. Moore et al.
NATURE REVIEWS CANCER (2010)
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy
Sean M. Armour et al.
AGING-US (2009)
mTOR Signaling Pathway Is a Target for the Treatment of Colorectal Cancer
Yan-Jie Zhang et al.
ANNALS OF SURGICAL ONCOLOGY (2009)
Critical and Diverse Involvement of Akt/Mammalian Target of Rapamycin Signaling in Human Lung Carcinomas
Yoh Dobashi et al.
CANCER (2009)
The role of mTOR in the management of solid tumors: An overview
Alex S. Strimpakos et al.
CANCER TREATMENT REVIEWS (2009)
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Nahum Sonenberg et al.
CELL (2009)
mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
Rogerio M. Castilho et al.
CELL STEM CELL (2009)
Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer
Pat Gulhati et al.
CLINICAL CANCER RESEARCH (2009)
An Emerging Role of mTOR in Lipid Biosynthesis
Mathieu Laplante et al.
CURRENT BIOLOGY (2009)
The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
Greg M. Delgoffe et al.
IMMUNITY (2009)
The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent Manner
Ilona Patursky-Polischuk et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Targeting the phosphoinositide 3-kinase pathway in cancer
Pixu Liu et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Common corruption of the mTOR signaling network in human tumors
S Menon et al.
ONCOGENE (2009)
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer
D Martin et al.
ONCOGENE (2009)
mTOR complex 2 in adipose tissue negatively controls whole-body growth
Nadine Cybulski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Myeloid-derived suppressor cells as regulators of the immune system
Dmitry I. Gabrilovich et al.
NATURE REVIEWS IMMUNOLOGY (2009)
Immunoregulatory functions of mTOR inhibition
Angus W. Thomson et al.
NATURE REVIEWS IMMUNOLOGY (2009)
A new Pharmacologic action of CCI-779 involves FKBP12-Independent inhibition of mTOR kinase activity and profound repression of global protein synthesis
Boris Shor et al.
CANCER RESEARCH (2008)
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Thomas Porstmann et al.
CELL METABOLISM (2008)
Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis
Micah J. Drummond et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2008)
MTOR is activated in the majority of malignant melanomas
Magdalena Karbowniczek et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)
Somatic mutations affect key pathways in lung adenocarcinoma
Li Ding et al.
NATURE (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity
Anil Kumar et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Targeting the mTOR signaling network in cancer
Gary G. Chiang et al.
TRENDS IN MOLECULAR MEDICINE (2007)
IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
Dung-Fang Lee et al.
CELL (2007)
The rapid activation of protein synthesis by growth hormone requires signaling through mTOR
Amanda A. Hayashi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
The regulation of AMPK β1, TSC2, and PTEN expression by p53:: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
Zhaohui Feng et al.
CANCER RESEARCH (2007)
Epigenetic Activation of a Subset of mRNAs by eIF4E Explains Its Effects on Cell Proliferation
Yael Mamane et al.
PLOS ONE (2007)
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
L. Liu et al.
ONCOGENE (2006)
Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases
C. Mayer et al.
ONCOGENE (2006)
Mechanisms of allergen specific immunotherapy - T-cell tolerance and more
M. Jutel et al.
ALLERGY (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
Li Ma et al.
CELL (2006)
Tumor antigen-specific T helper cells in cancer immunity and immunotherapy
KL Knutson et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2005)
The coordinate regulation of the p53 and rnTOR pathways in cells
ZH Feng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis
SK Frankel et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
L Ma et al.
CELL (2005)
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
XM Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Frequent genetic and biochemical alterations of the PI3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma
JMG Pedrero et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors
BA Ballif et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
eIF4E - from translation to transformation
Y Mamane et al.
ONCOGENE (2004)
mTOR-dependent activation of the transcription factor TIMA links rRNA synthesis to nutrient availability
C Mayer et al.
GENES & DEVELOPMENT (2004)
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
PP Roux et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The biology and clinical relevance of the PTEN tumor suppressor pathway
I Sansal et al.
JOURNAL OF CLINICAL ONCOLOGY (2004)
Regulation of peroxisome proliferator-activated receptor-γ activity by mammalian target of rapamycin and amino acids in adipogenesis
JE Kim et al.
DIABETES (2004)
Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716 Cdx2+/- compound mutant mice
K Aoki et al.
NATURE GENETICS (2003)
Inactivation of the tuberous sclerosis complex-1 and-2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
AR Tee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Phosphoinositide 3-kinase signalling - which way to target?
MP Wymann et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2003)
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
SS Schaim et al.
CURRENT BIOLOGY (2003)
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
Y Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation
M Stolovich et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Akt regulates growth by directly phosphorylating Tsc2
CJ Potter et al.
NATURE CELL BIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
K Hara et al.
CELL (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
I Vivanco et al.
NATURE REVIEWS CANCER (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
DC Fingar et al.
GENES & DEVELOPMENT (2002)
Identification of a conserved motif required for mTOR signaling
SS Schalm et al.
CURRENT BIOLOGY (2002)
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin and is independent of S6K1 and rpS6 phosphorylation
H Tang et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
H Harada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Regulation of translation initiation by FRAP/mTOR
AC Gingras et al.
GENES & DEVELOPMENT (2001)