相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Falcarindiol Stimulates Apoptotic and Autophagic Cell Death to Attenuate Cell Proliferation, Cell Division, and Metastasis through the PI3K/AKT/mTOR/p70S6K Pathway in Human Oral Squamous Cell Carcinomas
Kyung-Ran Park et al.
AMERICAN JOURNAL OF CHINESE MEDICINE (2022)
E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
Dong Wang et al.
MOLECULAR CELL (2022)
Follicular Fluid-Derived Exosomal MicroRNA-18b-5p Regulates PTEN-Mediated PI3K/Akt/mTOR Signaling Pathway to Inhibit Polycystic Ovary Syndrome Development
Zhi Zhou et al.
MOLECULAR NEUROBIOLOGY (2022)
mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment
Sahar Mafi et al.
FRONTIERS IN IMMUNOLOGY (2022)
Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021)
Patrik Oleksak et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Le Yu et al.
SEMINARS IN CANCER BIOLOGY (2022)
METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway
Xuehan Bi et al.
CANCER GENE THERAPY (2021)
Tomentosin inhibits cell proliferation and induces apoptosis in MOLT-4 leukemia cancer cells through the inhibition of mTOR/PI3K/Akt signaling pathway
Linlin Yang et al.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)
Eupafolin inhibits breast cancer cell proliferation and induces apoptosis by inhibiting the PI3K/Akt/mTOR pathway
Jiahui Wei et al.
ONCOLOGY LETTERS (2021)
Chaetocochin J, an epipolythiodioxopiperazine alkaloid, induces apoptosis and autophagy in colorectal cancer via AMPK and PI3K/AKT/ mTOR pathways
Song Hu et al.
BIOORGANIC CHEMISTRY (2021)
Atractylodin inhibited the migration and induced autophagy in cholangiocarcinoma cells via PI3K/AKT/mTOR and p38MAPK signalling pathways
Bishwanath Acharya et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)
Combining mTOR Inhibitors and T Cell-Based Immunotherapies in Cancer Treatment
Alexandre el Hage et al.
CANCERS (2021)
Rhein Suppresses Colorectal Cancer Cell Growth by Inhibiting the mTOR Pathway In Vitro and In Vivo
Haibo Zhang et al.
CANCERS (2021)
Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products
Iksen et al.
MOLECULES (2021)
CD155 Promotes the Progression of Cervical Cancer Cells Through AKT/mTOR and NF-κB Pathways
Lu Liu et al.
FRONTIERS IN ONCOLOGY (2021)
Poricoic acid A induces apoptosis and autophagy in ovarian cancer via modulating the mTOR/p70s6k signaling axis
Rui Ma et al.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2021)
MicroRNA-216b targets HK2 to potentiate autophagy and apoptosis of breast cancer cells via the mTOR signaling pathway
Ting Liu et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)
Targeting mTOR suppressed colon cancer growth through 4EBP1/eIF4E/PUMA pathway
Huanan Wang et al.
CANCER GENE THERAPY (2020)
Cross-talk between ribosome biogenesis, translation, and mTOR in CD133+4/CD44+prostate cancer stem cells
Z. Binal et al.
CLINICAL & TRANSLATIONAL ONCOLOGY (2020)
Cancer progression is mediated by proline catabolism in non-small cell lung cancer
Yating Liu et al.
ONCOGENE (2020)
Atractylenolide I inhibits colorectal cancer cell proliferation by affecting metabolism and stemness via AKT/mTOR signaling
Kuilong Wang et al.
PHYTOMEDICINE (2020)
Synergic effect of PD-1 blockade and endostar on the PI3K/AKT/mTOR-mediated autophagy and angiogenesis in Lewis lung carcinoma mouse model
Jing Wu et al.
BIOMEDICINE & PHARMACOTHERAPY (2020)
The future of cancer immunotherapy: microenvironment-targeting combinations
Yonina R. Murciano-Goroff et al.
CELL RESEARCH (2020)
Apigetrin induces extrinsic apoptosis, autophagy and G2/M phase cell cycle arrest through PI3K/AKT/mTOR pathway in AGS human gastric cancer cell
Seong Min Kim et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2020)
Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
Mei-lin Weng et al.
NATURE COMMUNICATIONS (2020)
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling
Boris Y. Shorning et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
被撤回的出版物: MicroRNA-381 facilitates autophagy and apoptosis in prostate cancer cells via inhibiting the RELN-mediated PI3K/AKT/mTOR signaling pathway (Retracted article. See vol. 324, 2023)
Wenbiao Liao et al.
LIFE SCIENCES (2020)
Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis
Pan Hong et al.
CELL DEATH & DISEASE (2020)
Vitexin suppresses renal cell carcinoma by regulating mTOR pathways
Yuhong Li et al.
TRANSLATIONAL ANDROLOGY AND UROLOGY (2020)
Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer
Khushbukhat Khan et al.
CANCER CELL INTERNATIONAL (2020)
Tumor-Associated Macrophages in Tumor Immunity
Yueyun Pan et al.
FRONTIERS IN IMMUNOLOGY (2020)
Arnicolide D Inhibits Triple Negative Breast Cancer Cell Proliferation by Suppression of Akt/mTOR and STAT3 Signaling Pathways
Zhao Qu et al.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)
M2 polarization of macrophages by Oncostatin M in hypoxic tumor microenvironment is mediated by mTORC2 and promotes tumor growth and metastasis
Richa Shrivastava et al.
CYTOKINE (2019)
The MTOR signaling pathway regulates macrophage differentiation from mouse myeloid progenitors by inhibiting autophagy
Meichao Zhang et al.
AUTOPHAGY (2019)
mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
Tian Tian et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Neuroinflammation and central PI3K/Akt/mTOR signal pathway contribute to bone cancer pain
Jian Zhang et al.
MOLECULAR PAIN (2019)
PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations
Yongshuai Jiang et al.
HUMAN VACCINES & IMMUNOTHERAPEUTICS (2019)
Translation of Human β-Actin mRNA is Regulated by mTOR Pathway
Irina Eliseeva et al.
GENES (2019)
Epstein-Barr virus-encoded LMP1 induces ectopic CD137 expression on Hodgkin and Reed-Sternberg cells via the PI3K-AKT-mTOR pathway
Sneha Priya Aravinth et al.
LEUKEMIA & LYMPHOMA (2019)
mTOR Inhibitors Can Enhance the Anti-Tumor Effects of DNA Vaccines through Modulating Dendritic Cell Function in the Tumor Microenvironment
Yu-Li Chen et al.
CANCERS (2019)
mTOR Signalling in Head and Neck Cancer: Heads Up
Fiona H. Tan et al.
CELLS (2019)
Inhibition of PI3K/Akt/mTOR signaling pathway alleviates ovarian cancer chemoresistance through reversing epithelial-mesenchymal transition and decreasing cancer stem cell marker expression
Junli Deng et al.
BMC CANCER (2019)
Tumor Microenvironment as A Game Changer in Cancer Radiotherapy
Magdalena Jarosz-Biej et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Targeting mTOR for cancer therapy
Hui Hua et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)
Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition
Clive Yik-Sham Chung et al.
NATURE CHEMICAL BIOLOGY (2019)
Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways
Gaurab Roy et al.
FRONTIERS IN ONCOLOGY (2019)
Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer
Kimiko L. Krieger et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Piperlongumine, a piper alkaloid targets Ras/PI3K/Akt/mTOR signaling axis to inhibit tumor cell growth and proliferation in DMH/DSS induced experimental colon cancer
Sandeep Kumar et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Effects of microRNA-513b on cell proliferation, apoptosis, invasion, and migration by targeting HMGB3 through regulation of mTOR signaling pathway in non-small-cell lung cancer
Jiying Wang et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2019)
Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer
Tulasigeri M. Totiger et al.
MOLECULAR CANCER THERAPEUTICS (2019)
The efficacy and safety of combination of PD-1 and CTLA-4 inhibitors: a meta-analysis
Kongju Wu et al.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2019)
Current Clinical Progress of PD-1/PD-L1 Immunotherapy and Potential Combination Treatment in Non-Small Cell Lung Cancer
Jia-Xin Li et al.
INTEGRATIVE CANCER THERAPIES (2019)
Gallic acid targets acute myeloid leukemia via Akt/mTOR-dependent mitochondrial respiration inhibition
Ruixin Gu et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Correlation between telomerase and mTOR pathway in cancer stem cells
Fatma Dogan et al.
GENE (2018)
Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors
Kristian M. Hargadon et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2018)
mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+ Regulatory T Cells
Im-Hong Sun et al.
JOURNAL OF IMMUNOLOGY (2018)
Phase II Study of Everolimus in Metastatic Malignant Melanoma (NCCTG-N0377, Alliance)
Jesus Vera Aguilera et al.
ONCOLOGIST (2018)
PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux
Jake S. O'Donnell et al.
SEMINARS IN CANCER BIOLOGY (2018)
Pre-clinical activity of targeting the PI3K/Akt/mTOR pathway in Burkitt lymphoma
Maria Bhatti et al.
Oncotarget (2018)
mTOR signaling-related MicroRNAs and Cancer involvement
Ping Wang et al.
JOURNAL OF CANCER (2018)
Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity
Sophie Langdon et al.
ONCOIMMUNOLOGY (2018)
Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, efficacy, and Limitations
Judith A. Seidel et al.
FRONTIERS IN ONCOLOGY (2018)
Rapalog combined with CCR4 antagonist improves anticancer vaccines efficacy
Laurent Beziaud et al.
INTERNATIONAL JOURNAL OF CANCER (2018)
Role of mTOR Signaling in Tumor Microenvironment: An Overview
Fabiana Conciatori et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition
Kara M. Ruicci et al.
ORAL ONCOLOGY (2018)
Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1 alpha nuclear translocation
Lin Zhang et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2018)
Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression
Dandan Yu et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2018)
Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer
Anya Alayev et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2
Stephen B. Keysar et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)
Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2
Stephen B. Keysar et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)
Combined activity of temozolomide and the mTOR inhibitor temsirolimus in metastatic melanoma involves DKK1
Heike Niessner et al.
EXPERIMENTAL DERMATOLOGY (2017)
Programmed Cell Death-1 (PD-1) Checkpoint Blockade in Combination With a Mammalian Target of Rapamycin Inhibitor Restrains Hepatocellular Carcinoma Growth Induced by Hepatoma Cell-Intrinsic PD-1
Hui Li et al.
HEPATOLOGY (2017)
Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway
Li-Min Feng et al.
JOURNAL OF BIOSCIENCES (2017)
Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish
Jia He et al.
JOURNAL OF GENETICS AND GENOMICS (2017)
Targeting the PI3K/AKT/mTOR signaling pathway as an effectively radiosensitizing strategy for treating human oral squamous cell carcinoma in vitro and in vivo
Chih-Chia Yu et al.
Oncotarget (2017)
Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways
Guanzhao Liang et al.
ONCOTARGET (2017)
PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome
Hashem O. Alsaab et al.
FRONTIERS IN PHARMACOLOGY (2017)
AR Signaling and the PI3K Pathway in Prostate Cancer
Megan Crumbaker et al.
CANCERS (2017)
MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy
Xi Ma et al.
AUTOPHAGY (2017)
Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway
Zhongbo Liu et al.
JOURNAL OF BIOMEDICAL RESEARCH (2017)
mTOR signaling in immune cells and its implications for cancer immunotherapy
Hu Zeng
CANCER LETTERS (2017)
Prospects for combining targeted and conventional cancer therapy with immunotherapy
Philip Gotwals et al.
NATURE REVIEWS CANCER (2017)
mTOR Signaling in Growth, Metabolism, and Disease
Robert A. Saxton et al.
CELL (2017)
Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer
Kristin J. Lastwika et al.
CANCER RESEARCH (2016)
Combination of mTOR and EGFR targeting in an orthotopic xenograft model of head and neck cancer
Alexandre Bozec et al.
LARYNGOSCOPE (2016)
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Jessica Okosun et al.
NATURE GENETICS (2016)
mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation
K. He et al.
ONCOGENE (2016)
The Lysosome as a Regulatory Hub
Rushika M. Perera et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32 (2016)
Cancer immunotherapy: the beginning of the end of cancer?
Sofia Farkona et al.
BMC MEDICINE (2016)
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation
Thomas Welte et al.
NATURE CELL BIOLOGY (2016)
Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis
J. Musa et al.
ONCOGENE (2016)
A systems study reveals concurrent activation of AMPK and mTOR by amino acids
Piero Dalle Pezze et al.
NATURE COMMUNICATIONS (2016)
mTOR: An attractive therapeutic target for osteosarcoma?
Liu Ding et al.
ONCOTARGET (2016)
A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-λB regulates head and neck squamous cell carcinoma proliferation
Zhipeng Li et al.
ONCOTARGET (2016)
Acquired resistance to anti-PD1 therapy: checkmate to checkpoint blockade?
Jake S. O'Donnell et al.
GENOME MEDICINE (2016)
Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers
Ellen C. Moore et al.
CANCER IMMUNOLOGY RESEARCH (2016)
Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function
Carla Garza-Lombo et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2016)
PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition
Samuel W. Brady et al.
CANCER BIOLOGY & THERAPY (2015)
Targeting drivers of melanoma with synthetic small molecules and phytochemicals
Leah Ray Strickland et al.
CANCER LETTERS (2015)
Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication
Nada Chaoul et al.
CANCER RESEARCH (2015)
mTOR coordinates protein synthesis, mitochondrial activity and proliferation
Masahiro Morita et al.
CELL CYCLE (2015)
mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
Kristen N. Pollizzi et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Friends Not Foes: CTLA-4 Blockade and mTOR Inhibition Cooperate during CD8+ T Cell Priming To Promote Memory Formation and Metabolic Readiness
Virginia A. Pedicord et al.
JOURNAL OF IMMUNOLOGY (2015)
Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma
Smitha R. Georgy et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses
Lifang Zhang et al.
MOLECULAR CANCER (2015)
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
Sharad Shrestha et al.
NATURE IMMUNOLOGY (2015)
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
Alexandria Huynh et al.
NATURE IMMUNOLOGY (2015)
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells
Sarah A. Head et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells
Jen-Pi Tsai et al.
ONCOTARGET (2015)
Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma
Smitha R. Georgy et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2015)
PI3K/mTOR Dual Inhibitor VS-5584 Preferentially Targets Cancer Stem Cells
Vihren N. Kolev et al.
CANCER RESEARCH (2015)
VS-5584, a Novel PI3K-mTOR Dual Inhibitor, Inhibits Melanoma Cell Growth In Vitro and In Vivo
Zheren Shao et al.
PLOS ONE (2015)
Regulation of innate immune cell function by mTOR
Thomas Weichhart et al.
NATURE REVIEWS IMMUNOLOGY (2015)
Combined MTOR and autophagy inhibition Phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma
Reshma Rangwala et al.
AUTOPHAGY (2014)
mTOR signaling in tumorigenesis
Kai Xu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2014)
Targeting bone metastatic cancer: Role of the mTOR pathway
Francesco Bertoldo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2014)
Combination of Foxp3+T cells depletion and mTOR inhibitor enhances immune memory and controls cancer growth
Yanping Wang et al.
CANCER RESEARCH (2014)
Reverse-Phase Protein Array Profiling of Oropharyngeal Cancer and Significance of PIK3CA Mutations in HPV-Associated Head and Neck Cancer
Andrew Sewell et al.
CLINICAL CANCER RESEARCH (2014)
Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice
Hongfeng Jiang et al.
DIABETOLOGIA (2014)
Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways
Juan Xia et al.
FOOD AND CHEMICAL TOXICOLOGY (2014)
mTOR signaling, Tregs and immune modulation
Nicole M. Chapman et al.
IMMUNOTHERAPY (2014)
Preclinical trial of a new dual mTOR inhibitor, MLN0128, using renal cell carcinoma tumorgrafts
Alexandre Ingels et al.
INTERNATIONAL JOURNAL OF CANCER (2014)
Role of TGF-β Signaling in Generation of CD39+CD73+ Myeloid Cells in Tumors
Sergey V. Ryzhov et al.
JOURNAL OF IMMUNOLOGY (2014)
SKLB-M8 Induces Apoptosis Through the AKT/mTOR Signaling Pathway in Melanoma Models and Inhibits Angiogenesis With Decrease of ERK1/2 Phosphorylation
Jingjing Wang et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2014)
Resveratrol induces apoptosis of bladder cancer cells via miR-21 regulation of the Akt/Bcl-2 signaling pathway
Chenxi Zhou et al.
MOLECULAR MEDICINE REPORTS (2014)
Molecular regulation of effector and memory T cell differentiation
John T. Chang et al.
NATURE IMMUNOLOGY (2014)
MELANOMA IN 2013 Melanoma-the run of success continues
Dirk Schadendorf et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2014)
The malignant melanoma landscape
Rachel M. Webster et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways
Jia Liu et al.
ONCOLOGY REPORTS (2014)
Mechanisms associated with resistance to tamoxifen in estrogen receptor-positive breast cancer (Review)
Rubi Viedma-Rodriguez et al.
ONCOLOGY REPORTS (2014)
Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM-5 Leukemia Cells
Sun-Mi Yun et al.
PHYTOTHERAPY RESEARCH (2014)
Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability
Bo Ram Seo et al.
PLOS ONE (2014)
Activation of Akt/mTOR Pathway Is Associated with Poor Prognosis of Nasopharyngeal Carcinoma
Weiyuan Wang et al.
PLOS ONE (2014)
Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR
Peter J. Belmont et al.
SCIENCE SIGNALING (2014)
Growing knowledge of the mTOR signaling network
Kezhen Huang et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)
Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner
Rachel Miloslavski et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2014)
mTOR pathway in colorectal cancer: an update
Maria Giovanna Francipane et al.
ONCOTARGET (2014)
The nuclear import of ribosomal proteins is regulated by mTOR
Dubek Kazyken et al.
ONCOTARGET (2014)
PD-L1 Expression in Triple-Negative Breast Cancer
Elizabeth A. Mittendorf et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy
Hai-Xin Yuan et al.
AUTOPHAGY (2013)
Many roads from mTOR to eIF4F
Carson C. Thoreen
BIOCHEMICAL SOCIETY TRANSACTIONS (2013)
MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways
X-J Li et al.
BRITISH JOURNAL OF CANCER (2013)
Exploration of Genome-Wide Circulating MicroRNA in Hepatocellular Carcinoma: MiR-483-5p as a Potential Biomarker
Jing Shen et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2013)
mTOR in aging, metabolism, and cancer
Marion Cornu et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2013)
New Molecular Targets in the Treatment of NSCLC
Clorinda Schettino et al.
CURRENT PHARMACEUTICAL DESIGN (2013)
Tamoxifen resistance: From bench to bedside
Marjolein Droog et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2013)
Phase 2 Trial of Single-agent Everolimus in Chemotherapy-naive Patients with Castration-resistant Prostate Cancer (SAKK 08/08)
Arnoud J. Templeton et al.
EUROPEAN UROLOGY (2013)
Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells
Tianpeng Chen et al.
FOOD CHEMISTRY (2013)
Rapamycin unbalances the polarization of human macrophages to M1
Alessia Mercalli et al.
IMMUNOLOGY (2013)
The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells
Dennis Lindau et al.
IMMUNOLOGY (2013)
Nutrient regulation of the mTOR Complex 1 signaling pathway
Sang Gyun Kim et al.
MOLECULES AND CELLS (2013)
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
Alejo Efeyan et al.
NATURE (2013)
mTOR kinase structure, mechanism and regulation
Haijuan Yang et al.
NATURE (2013)
MicroRNA-99a/100 promotes apoptosis by targeting mTOR in human esophageal squamous cell carcinoma
Jian Sun et al.
MEDICAL ONCOLOGY (2013)
The Effect of Gartanin, a Naturally Occurring Xanthone in Mangosteen Juice, on the mTOR Pathway, Autophagy, Apoptosis, and the Growth of Human Urinary Bladder Cancer Cell Lines
Zhongbo Liu et al.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2013)
Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK
A. Avivar-Valderas et al.
ONCOGENE (2013)
Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancer
U. Wazir et al.
ONCOLOGY REPORTS (2013)
Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
Issam Ben-Sahra et al.
SCIENCE (2013)
Phosphatidic acid and lipid-sensing by mTOR
David A. Foster
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)
Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance
L. Chang et al.
CELL DEATH & DISEASE (2013)
The TSC-mTOR pathway regulates macrophage polarization
Vanessa Byles et al.
NATURE COMMUNICATIONS (2013)
mTOR Inhibition Improves Antitumor Effects of Vaccination with Antigen-Encoding RNA
Mustafa Diken et al.
CANCER IMMUNOLOGY RESEARCH (2013)
PD-1 as a potential target in cancer therapy
David F. McDermott et al.
CANCER MEDICINE (2013)
Dysregulation of mTOR activity through LKB1 inactivation
Wei Zhou et al.
CHINESE JOURNAL OF CANCER (2013)
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
Jose A. Martina et al.
AUTOPHAGY (2012)
Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma
Toshihito Suda et al.
BMC CANCER (2012)
mTOR in breast cancer: Differential expression in triple-negative and non-triple-negative tumors
S. Walsh et al.
BREAST (2012)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model
Zhi-Jun Sun et al.
CLINICAL CANCER RESEARCH (2012)
Withdrawal of Essential Amino Acids Increases Autophagy by a Pathway Involving Ca2+/Calmodulin-dependent Kinase Kinase-β (CaMKK-β)
Ghita Ghislat et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Atg9 vesicles are an important membrane source during early steps of autophagosome formation
Hayashi Yamamoto et al.
JOURNAL OF CELL BIOLOGY (2012)
Major Response to Everolimus in Melanoma With Acquired Imatinib Resistance
Lu Si et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Hyperactivation of mTOR critically regulates abnormal osteoclastogenesis in neurofibromatosis type 1
Junrong Ma et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2012)
The mTOR Pathway in Lung Cancer and Implications for Therapy and Biomarker Analysis
Simon Ekman et al.
JOURNAL OF THORACIC ONCOLOGY (2012)
Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling
Shubham Shrivastava et al.
JOURNAL OF VIROLOGY (2012)
Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation
Y. Bian et al.
ONCOGENE (2012)
The emerging role of mTORC1 signaling in placental nutrient-sensing
T. Jansson et al.
PLACENTA (2012)
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling
Chongben Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Charting the Landscape of Tandem BRCT Domain-Mediated Protein Interactions
Nicholas T. Woods et al.
SCIENCE SIGNALING (2012)
mTOR, linking metabolism and immunity
Xiaojin Xu et al.
SEMINARS IN IMMUNOLOGY (2012)
mTOR and metabolic pathways in T cell quiescence and functional activation
Kai Yang et al.
SEMINARS IN IMMUNOLOGY (2012)
Vaccines for Melanoma and Renal Cell Carcinoma
Howard L. Kaufman
SEMINARS IN ONCOLOGY (2012)
Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response.
James A. McCubrey et al.
ONCOTARGET (2012)
PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ
Yutaka Kurebayashi et al.
CELL REPORTS (2012)
Overcoming breast cancer drug resistance with mTOR inhibitors. Could it be a myth or a real possibility in the short-term future?
Nadia Margariti et al.
BREAST CANCER RESEARCH AND TREATMENT (2011)
Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines
Y. Wang et al.
BRITISH JOURNAL OF CANCER (2011)
mTOR Kinase Inhibitor AZD8055 Enhances the Immunotherapeutic Activity of an Agonist CD40 Antibody in Cancer Treatment
Qun Jiang et al.
CANCER RESEARCH (2011)
mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
Pat Gulhati et al.
CANCER RESEARCH (2011)
High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1
Paige Yellen et al.
CELL CYCLE (2011)
mTOR signaling in protein homeostasis Less is more?
Crystal S. Conn et al.
CELL CYCLE (2011)
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
Ruoning Wang et al.
IMMUNITY (2011)
Alkaline Stress-Induced Autophagy is Mediated by mTORC1 Inactivation
Jinkyu Suk et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2011)
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
Greg M. Delgoffe et al.
NATURE IMMUNOLOGY (2011)
Rapamycin passes the torch: a new generation of mTOR inhibitors
Don Benjamin et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer
Jatin Roper et al.
PLOS ONE (2011)
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Qian Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Bevacizumab and Everolimus in the Treatment of Patients With Metastatic Melanoma
John D. Hainsworth et al.
CANCER (2010)
Activation of mTOR signaling pathway contributes to survival of cervical cancer cells
Jing Ji et al.
GYNECOLOGIC ONCOLOGY (2010)
EphA2 Mutation in Lung Squamous Cell Carcinoma Promotes Increased Cell Survival, Cell Invasion, Focal Adhesions, and Mammalian Target of Rapamycin Activation
Leonardo Faoro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo
Didier Roulin et al.
MOLECULAR CANCER (2010)
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
Weiming Ouyang et al.
NATURE IMMUNOLOGY (2010)
Immune Checkpoint Proteins: A New Therapeutic Paradigm for Cancer-Preclinical Background: CTLA-4 and PD-1 Blockade
Jeffrey Weber
SEMINARS IN ONCOLOGY (2010)
Why do viruses cause cancer? Highlights of the first century of human tumour virology
Patrick S. Moore et al.
NATURE REVIEWS CANCER (2010)
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy
Sean M. Armour et al.
AGING-US (2009)
mTOR Signaling Pathway Is a Target for the Treatment of Colorectal Cancer
Yan-Jie Zhang et al.
ANNALS OF SURGICAL ONCOLOGY (2009)
Critical and Diverse Involvement of Akt/Mammalian Target of Rapamycin Signaling in Human Lung Carcinomas
Yoh Dobashi et al.
CANCER (2009)
The role of mTOR in the management of solid tumors: An overview
Alex S. Strimpakos et al.
CANCER TREATMENT REVIEWS (2009)
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Nahum Sonenberg et al.
CELL (2009)
mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
Rogerio M. Castilho et al.
CELL STEM CELL (2009)
Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer
Pat Gulhati et al.
CLINICAL CANCER RESEARCH (2009)
An Emerging Role of mTOR in Lipid Biosynthesis
Mathieu Laplante et al.
CURRENT BIOLOGY (2009)
The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment
Greg M. Delgoffe et al.
IMMUNITY (2009)
The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent Manner
Ilona Patursky-Polischuk et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Targeting the phosphoinositide 3-kinase pathway in cancer
Pixu Liu et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Common corruption of the mTOR signaling network in human tumors
S Menon et al.
ONCOGENE (2009)
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer
D Martin et al.
ONCOGENE (2009)
mTOR complex 2 in adipose tissue negatively controls whole-body growth
Nadine Cybulski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Myeloid-derived suppressor cells as regulators of the immune system
Dmitry I. Gabrilovich et al.
NATURE REVIEWS IMMUNOLOGY (2009)
Immunoregulatory functions of mTOR inhibition
Angus W. Thomson et al.
NATURE REVIEWS IMMUNOLOGY (2009)
A new Pharmacologic action of CCI-779 involves FKBP12-Independent inhibition of mTOR kinase activity and profound repression of global protein synthesis
Boris Shor et al.
CANCER RESEARCH (2008)
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Thomas Porstmann et al.
CELL METABOLISM (2008)
Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis
Micah J. Drummond et al.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2008)
MTOR is activated in the majority of malignant melanomas
Magdalena Karbowniczek et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)
Somatic mutations affect key pathways in lung adenocarcinoma
Li Ding et al.
NATURE (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances basal glycogen synthase activity
Anil Kumar et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Targeting the mTOR signaling network in cancer
Gary G. Chiang et al.
TRENDS IN MOLECULAR MEDICINE (2007)
IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
Dung-Fang Lee et al.
CELL (2007)
The rapid activation of protein synthesis by growth hormone requires signaling through mTOR
Amanda A. Hayashi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
The regulation of AMPK β1, TSC2, and PTEN expression by p53:: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
Zhaohui Feng et al.
CANCER RESEARCH (2007)
Epigenetic Activation of a Subset of mRNAs by eIF4E Explains Its Effects on Cell Proliferation
Yael Mamane et al.
PLOS ONE (2007)
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
L. Liu et al.
ONCOGENE (2006)
Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases
C. Mayer et al.
ONCOGENE (2006)
Mechanisms of allergen specific immunotherapy - T-cell tolerance and more
M. Jutel et al.
ALLERGY (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
Li Ma et al.
CELL (2006)
Tumor antigen-specific T helper cells in cancer immunity and immunotherapy
KL Knutson et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2005)
The coordinate regulation of the p53 and rnTOR pathways in cells
ZH Feng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis
SK Frankel et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
L Ma et al.
CELL (2005)
Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
XM Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Frequent genetic and biochemical alterations of the PI3-K/AKT/PTEN pathway in head and neck squamous cell carcinoma
JMG Pedrero et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors
BA Ballif et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
eIF4E - from translation to transformation
Y Mamane et al.
ONCOGENE (2004)
mTOR-dependent activation of the transcription factor TIMA links rRNA synthesis to nutrient availability
C Mayer et al.
GENES & DEVELOPMENT (2004)
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
PP Roux et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The biology and clinical relevance of the PTEN tumor suppressor pathway
I Sansal et al.
JOURNAL OF CLINICAL ONCOLOGY (2004)
Regulation of peroxisome proliferator-activated receptor-γ activity by mammalian target of rapamycin and amino acids in adipogenesis
JE Kim et al.
DIABETES (2004)
Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716 Cdx2+/- compound mutant mice
K Aoki et al.
NATURE GENETICS (2003)
Inactivation of the tuberous sclerosis complex-1 and-2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
AR Tee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Phosphoinositide 3-kinase signalling - which way to target?
MP Wymann et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2003)
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
SS Schaim et al.
CURRENT BIOLOGY (2003)
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
Y Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation
M Stolovich et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Akt regulates growth by directly phosphorylating Tsc2
CJ Potter et al.
NATURE CELL BIOLOGY (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
K Hara et al.
CELL (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
I Vivanco et al.
NATURE REVIEWS CANCER (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
DC Fingar et al.
GENES & DEVELOPMENT (2002)
Identification of a conserved motif required for mTOR signaling
SS Schalm et al.
CURRENT BIOLOGY (2002)
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin and is independent of S6K1 and rpS6 phosphorylation
H Tang et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
H Harada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Regulation of translation initiation by FRAP/mTOR
AC Gingras et al.
GENES & DEVELOPMENT (2001)
分享论文
