期刊
2022 IEEE 22ND INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (NANO)
卷 -, 期 -, 页码 337-340出版社
IEEE
DOI: 10.1109/NANO54668.2022.9928706
关键词
gold nanoparticles; polyethyleneimine; colloidal stability; nanotoxicity; nanoscale positive control
We report on the synthesis and characterization of a stability-enhanced suspension of gold-polyethyleneimine conjugates (Au-PEIs). The nanoparticles showed excellent colloidal stability in aqueous environments and demonstrated significant cytotoxicity, making them a potential universal nanoscale positive control material for nanotoxicity studies.
We report on a stability-enhanced suspension of gold-polyethyleneimine conjugates (Au-PEIs), prepared by an optimized synthetic process. The physicochemical properties of Au-PEIs were characterized using several analytical instruments including dynamic light scattering, UV-Vis, transmission electron microscope, and atomic force microscope. The nanoparticles in this report have shown excellent colloidal stability to avoid particle-particle interactions in various aqueous environments, which is very critical to become effective materials in nanomedicine. Most importantly, the cytotoxicity of Au-PEIs has been investigated by cell viability assays using a variety of cell lines (CHO K1, HeLa, and A549) and has significant toxicity in common, appeared to be more toxic than a traditional positive control (CdSO4). This suggests the potential for use as a universal nanoscale positive control material in nanotoxicity studies.
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