The Centennial Collection of VDR Ligands: Metabolites, Analogs, Hybrids and Non-Secosteroidal Ligands

Since the discovery of vitamin D a century ago, a great number of metabolites, analogs, hybrids and nonsteroidal VDR ligands have been developed. An enormous effort has been made to synthesize compounds which present beneficial properties while attaining lower calcium serum levels than calcitriol. This structural review covers VDR ligands published to date.

Automated summary

This study provides a comprehensive review of VDR ligands published so far, including metabolites, analogs, and nonsteroidal compounds of vitamin D. It aims to identify compounds with beneficial properties while reducing serum calcium levels of active vitamin D.