Synthesis of acridines via copper-catalyzed amination/annulation cascades between arylboronic acids and anthranils

Copper-catalyzed tandem cyclization reactions between arylboronic acids and anthranils have been established, providing new approaches for one-pot assembly of azacycle acridines. This one-pot protocol features simple operation, precious-metal-free conditions and good functional group compatibility, thus providing an efficient approach for the synthesis of a variety of acridines in moderate to good yields.

Automated summary

This study established copper-catalyzed tandem cyclization reactions between arylboronic acids and anthranils, providing a new approach for one-pot assembly of azacycle acridines. The protocol features simple operation, precious-metal-free conditions, and good functional group compatibility, offering an efficient method for synthesizing a variety of acridines in moderate to good yields.