COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis

Article Immunology

Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study

Olivia S. Kates et al.

Summary: The mortality rate among SOT recipients hospitalized for COVID-19 was 20.5%, with age and underlying comorbidities being the major drivers of mortality, rather than measures related to immunosuppression intensity.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Urology & Nephrology

Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria

Shreeram Akilesh et al.

Summary: This multicenter evaluation revealed that even mildly symptomatic cases of COVID-19 were associated with acute kidney injury and/or heavy proteinuria, leading to some patients requiring dialysis. Acute tubular injury was the most common renal pathology observed, but uncommon findings such as collapsing glomerulopathy and endothelial injury were also detected. Most patients progressed to irreversible kidney injury and dialysis.

AMERICAN JOURNAL OF KIDNEY DISEASES (2021)

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Article Geriatrics & Gerontology

Acute Kidney Injury Is Associated With In-hospital Mortality in Older Patients With COVID-19

Qi Yan et al.

Summary: Acute kidney injury is not uncommon in older patients with COVID-19 and is associated with a high risk of death. Patients with AKI have a higher mortality rate, and physicians should be aware of the risk of AKI in older patients with COVID-19.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Surgery

Outcomes of COVID-19 in hospitalized solid organ transplant recipients compared to a matched cohort of non-transplant patients at a national healthcare system in the United States

Arielle M. Fisher et al.

Summary: This study compared the clinical outcomes of SOT recipients with COVID-19 to non-SOT recipients during hospitalization, finding that SOT recipients had higher mortality rates and were more likely to require mechanical ventilation, develop acute kidney injury, and receive vasopressor support during hospitalization.

CLINICAL TRANSPLANTATION (2021)

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Review Infectious Diseases

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

Stephany Beyerstedt et al.

Summary: ACE2 plays a crucial role in COVID-19, with its expression potentially having paradoxical effects, aiding SARS-CoV-2 pathogenicity while also limiting viral infection.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2021)

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Article Endocrinology & Metabolism

Does inpatient hyperglycemia predict a worse outcome in COVID-19 intensive care unit patients?

Aisha R. Saand et al.

Summary: The study shows that hyperglycemia in COVID-19 patients is significantly associated with prolonged ICU stay, higher need of mechanical ventilation, and increased risk of mortality. Old age and hyperglycemia are the main predictors of in-hospital mortality.

JOURNAL OF DIABETES (2021)

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Article Endocrinology & Metabolism

Hyperglycemia associated with lymphopenia and disease severity of COVID-19 in type 2 diabetes mellitus

Yangyang Cheng et al.

Summary: COVID-19 patients with T2DM are at higher risk and more likely to worsen from moderate to severe cases. High HbA1c, IL-6, and lymphocyte count are risk factors predicting the severity of COVID-19 in patients with T2DM.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2021)

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Article Endocrinology & Metabolism

Visceral fat is associated to the severity of COVID-19

Guillaume Favre et al.

Summary: The study found that visceral fat accumulation is associated with severe COVID-19 in European adults, while subcutaneous fat is not. An area of visceral fat greater than or equal to 128.5 cm(2) was identified as the best predictor for severe COVID-19.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Article Transplantation

The spectrum of kidney biopsies in hospitalized patients with COVID-19, acute kidney injury and/or proteinuria

Sophie Ferlicot et al.

Summary: This study examines the spectrum of kidney lesions in patients with COVID-19. Acute tubular injury is correlated with COVID-19 severity, while the pattern of glomerular injury is intimately associated with the expression of APOL1 risk variants.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

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Article Multidisciplinary Sciences

A propensity score-matched analysis of mortality in solid organ transplant patients with COVID-19 compared to non-solid organ transplant patients

Laura Linares et al.

Summary: In the study analyzing the outcomes of COVID-19 in solid organ transplant (SOT) recipients, it was found that there were no significant differences between SOT recipients and non-transplant patients. Factors associated with higher mortality included older age, higher C-reactive protein levels, and higher serum creatinine levels on admission. The clinical outcomes of SARS-CoV-2 infection in SOT recipients were similar to those observed in the non-transplant population, with SOT not being associated with worse outcomes.

PLOS ONE (2021)

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Review Endocrinology & Metabolism

Diabetes, obesity, and insulin resistance in COVID-19: molecular interrelationship and therapeutic implications

Andrey Santos et al.

Summary: This review discusses the different mechanisms contributing to the pathophysiology of COVID-19, such as viral entrance, direct viral toxicity, endothelial dysfunction, and more. It is shown that viral infection triggers an integrated stress response, causing insulin resistance and synergizing with hormonal resistance from obesity and diabetes to worsen the severity of the disease. Additionally, the potential beneficial effects of drugs used to treat insulin resistance and diabetes in COVID-19 patients are explored.

DIABETOLOGY & METABOLIC SYNDROME (2021)

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Article Endocrinology & Metabolism

Immunological Characteristics in Type 2 Diabetes Mellitus Among COVID-19 Patients

Meifang Han et al.

Summary: The study found that COVID-19 patients with type 2 diabetes mellitus (T2DM) were more likely to have lymphopenia, hyperglycemia, and higher levels of certain laboratory parameters. The mortality rate was significantly elevated in diabetic cases, along with higher levels of inflammatory cytokines.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Infectious Diseases

Clinical characteristics and factors associated with hospital admission or death in 43 103 adult outpatients with coronavirus disease 2019 managed with the Covidom telesurveillance solution: a prospective cohort study

Youri Yordanov et al.

Summary: This study found that clinical worsening among COVID-19 outpatients is rare, with factors such as male sex, older age, obesity, and comorbidities like chronic renal disease or active cancer independently associated with clinical worsening. However, loss of smell or taste may reduce the probability of worsening.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Surgery

Recovery of kidney function after AKI because of COVID-19 in kidney transplant recipients

Divya Bajpai et al.

Summary: This multicenter observational study evaluated short-term clinical outcomes of kidney transplant recipients with acute kidney injury (AKI) secondary to COVID-19. The study found that some patients did not fully recover graft function post-AKI, with factors like baseline eGFR, proteinuria, orthostatic hypotension influencing incomplete recovery.

TRANSPLANT INTERNATIONAL (2021)

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Article Immunology

The Full Spectrum of COVID-19 Development and Recovery Among Kidney Transplant Recipients

Marina P. Cristelli et al.

Summary: This study confirms a high 28-day fatality rate of COVID-19 among kidney transplant recipients, with age and comorbidities being primary factors. Allograft dysfunction was frequently observed with a variety of histologic lesions and high rates of complications and graft loss. Seroconversion was common among survivors and the persistence of viral shedding requires further investigation.

TRANSPLANTATION (2021)

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Article Multidisciplinary Sciences

Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19

Abu Saleh Md Moin et al.

Summary: The study found that in obese type 2 diabetes patients, macrophage activation markers were elevated at baseline, but did not change after normalization of blood glucose, potentially increasing the risk of severe infection complicated by ARDS.

SCIENTIFIC REPORTS (2021)

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Article Endocrinology & Metabolism

Atherogenic Dyslipidemia on Admission Is Associated With Poorer Outcome in People With and Without Diabetes Hospitalized for COVID-19

Alfonso Bellia et al.

Summary: Identifying metabolic factors associated with critical disease can help improve the management of COVID-19 patients. The presence of atherogenic dyslipidemia and high triglycerides are associated with a more severe in-hospital course of COVID-19. Further investigation is needed to understand the role of insulin resistance and related lipid abnormalities in the pathogenesis of COVID-19.

DIABETES CARE (2021)

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Article Multidisciplinary Sciences

Viral infiltration of pancreatic islets in patients with COVID-19

Charlotte Steenblock et al.

Summary: This study comprehensively analyzed pancreatic tissues from COVID-19 patients and found detectable SARS-CoV-2 viral infiltration in beta-cells, potentially contributing to metabolic dysregulation. Even in the absence of overt new-onset diabetes, viral infection of pancreatic beta-cells may lead to varying degrees of metabolic abnormalities.

NATURE COMMUNICATIONS (2021)

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Article Cardiac & Cardiovascular Systems

Chronic Cardio-Metabolic Disease Increases the Risk of Worse Outcomes Among Hospitalized Patients With COVID-19: A Multicenter, Retrospective, and Real-World Study

Qijian Chen et al.

Summary: Patients with underlying cardio-metabolic disease had higher risks of complications, mortality, and the need for intensive care and mechanical ventilation in COVID-19. The more cardio-metabolic diseases a patient had, the higher the mortality rate. Overall, cardio-metabolic disease was associated with worse outcomes in hospitalized COVID-19 patients.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Medicine, General & Internal

Estimating risk of mechanical ventilation and in-hospital mortality among adult COVID-19 patients admitted to Mass General Brigham: The VICE and DICE scores

Christopher J. Nicholson et al.

Summary: This study identified risk factors upon hospital admission associated with COVID-19 ventilation need and in-hospital mortality, leading to the development of Ventilation in COVID Estimator (VICE) and Death in COVID Estimator (DICE) risk scores to assist healthcare providers in determining appropriate management for patients.

ECLINICALMEDICINE (2021)

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Article Endocrinology & Metabolism

SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas

Janis A. Mueller et al.

Summary: The study shows that SARS-CoV-2 can infect and impact insulin secretion in human pancreatic cells, potentially contributing to metabolic dysregulation observed in COVID-19 patients.

NATURE METABOLISM (2021)

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Article Cardiac & Cardiovascular Systems

Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19

Huihui Ren et al.

CARDIOVASCULAR DIABETOLOGY (2020)

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Article Medicine, General & Internal

Features of 20133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Annemarie B. Docherty et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Review Peripheral Vascular Disease

Hypertension is associated with increased mortality and severity of disease in COVID-19 pneumonia: A systematic review, meta-analysis and meta-regression

Raymond Pranata et al.

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM (2020)

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Article Urology & Nephrology

Kidney disease is associated with in-hospital death of patients with COVID-19

Yichun Cheng et al.

KIDNEY INTERNATIONAL (2020)

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Article Urology & Nephrology

Acute kidney injury in patients hospitalized with COVID-19

Jamie S. Hirsch et al.

KIDNEY INTERNATIONAL (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Article Critical Care Medicine

Management of acute kidney injury in patients with COVID-19

Claudio Ronco et al.

LANCET RESPIRATORY MEDICINE (2020)

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Article Surgery

COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium

Paolo Cravedi et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

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Article Transplantation

Clinical characteristics and risk factors for severe COVID‐19 in hospitalized kidney transplant recipients: A multicentric cohort study

A Favà et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

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Article Endocrinology & Metabolism

Hyperglycemia at Hospital Admission Is Associated With Severity of the Prognosis in Patients Hospitalized for COVID-19: The Pisa COVID-19 Study

Alberto Coppelli et al.

DIABETES CARE (2020)

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Article Endocrinology & Metabolism

Analysis of the lymphocyte count in type 2 diabetic patients with coronavirus disease (COVID-19): A retrospective study in a centralized treatment center

Dingye Wu et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

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Article Endocrinology & Metabolism

Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi-centre retrospective study

Sufei Wang et al.

DIABETOLOGIA (2020)

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Article Hematology

Endothelial Dysfunction and Thrombosis in Patients With COVID-19-Brief Report

Seigo Nagashima et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Correction Cell Biology

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis (vol 32, pg 437, 2020)

Ana Campos Codo et al.

CELL METABOLISM (2020)

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Article Endocrinology & Metabolism

Expression of ACE2, the SARS-CoV-2 Receptor, in Lung Tissue of Patients With Type 2 Diabetes

Sara R. A. Wijnant et al.

DIABETES (2020)

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Article Endocrinology & Metabolism

Hyperglycemia is a strong predictor of poor prognosis in COVID-19

Sheng-ping Liu et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

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Article Endocrinology & Metabolism

Newly-diagnosed diabetes and admission hyperglycemia predict COVID-19 severity by aggravating respiratory deterioration

Gian Paolo Fadini et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

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Article Endocrinology & Metabolism

Risk and predictors of in-hospital mortality from COVID-19 in patients with diabetes and cardiovascular disease

Hadith Rastad et al.

DIABETOLOGY & METABOLIC SYNDROME (2020)

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Review Biochemistry & Molecular Biology

SARS-CoV-2/Renin-Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle

Andrea Gonzalez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Urology & Nephrology

An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants

Sophie Caillard et al.

KIDNEY INTERNATIONAL (2020)

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Article Cell Biology

Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19

Irina Kusmartseva et al.

CELL METABOLISM (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain

Leon Fodoulian et al.

ISCIENCE (2020)

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Review Pharmacology & Pharmacy

Acute kidney injury is associated with severe infection and fatality in patients with COVID-19: A systematic review and meta-analysis of 40 studies and 24,527 patients

Mengjiao Shao et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Endocrinology & Metabolism

Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis

Ashish Kumar et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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Review Endocrinology & Metabolism

Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia A systematic review, meta analysis, and meta-regression

Ian Huang et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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Article Critical Care Medicine

Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China

Zhilin Zeng et al.

CRITICAL CARE (2020)

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Article Endocrinology & Metabolism

Diabetes Mellitus and Its Cardiovascular Complications: New Insights into an Old Disease

Celestino Sardu et al.

JOURNAL OF DIABETES RESEARCH (2019)

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Review Urology & Nephrology

Proteinuria as a Surrogate Outcome in CKD: Report of a Scientific Workshop Sponsored by the National Kidney Foundation and the US Food and Drug Administration

Andrew S. Levey et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2009)

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COVID-19 in Kidney Transplant Recipients With Diabetes Mellitus: A Propensity Score Matching Analysis

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