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MRI and Histological Analysis of Beta-Amyloid Plaques in Both Human Alzheimer's Disease and APP/PS1 Transgenic Mice
Mark D. Meadowcroft et al.
JOURNAL OF MAGNETIC RESONANCE IMAGING (2009)
Design, Synthesis, and Biological Evaluation of New 5-HT4 Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer's Disease
Olivier Russo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Redox-Linked Conformational Dynamics in Apoptosis-Inducing Factor
Irina F. Sevrioukova
JOURNAL OF MOLECULAR BIOLOGY (2009)
MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria
Lucia Banci et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Brain Drug-Metabolizing Cytochrome P450 Enzymes are Active In Vivo, Demonstrated by Mechanism-Based Enzyme Inhibition
Sharon Miksys et al.
NEUROPSYCHOPHARMACOLOGY (2009)
Pharmacologic treatment of advanced Parkinson's disease: A meta-analysis of COMT inhibitors and MAO-B inhibitors
Ripple Talati et al.
PARKINSONISM & RELATED DISORDERS (2009)
MicroRNAs Regulate CYP3A4 Expression via Direct and Indirect Targeting
Yu-Zhuo Pan et al.
DRUG METABOLISM AND DISPOSITION (2009)
Comparison of the structural properties of the active site cavities of human and rat monoamine oxidase a and B in their soluble and membrane-bound forms
Anup K. Upadhyay et al.
BIOCHEMISTRY (2008)
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds
Lorna Piazzi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Amyloid-cholinesterase interactions - Implications for Alzheimer's disease
Nibaldo C. Inestrosa et al.
FEBS JOURNAL (2008)
Mitochondrial Biogenesis, Switching the Sorting Pathway of the Intermembrane Space Receptor Mia40
Agnieszka Chacinska et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation
Pelayo Camps et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Loss of apoptosis-inducing factor results in cell-type-specific neurogenesis defects
Ryuta Ishimura et al.
JOURNAL OF NEUROSCIENCE (2008)
Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion
Mickael M. J. Cohen et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands
Jonrit Halling et al.
PHARMACOGENETICS AND GENOMICS (2008)
Cytochrome P450 2E1 in the substantia nigra: Relevance for dopaminergic neurotransmission and free radical production
H. Niazi Shahabi et al.
SYNAPSE (2008)
Redox-dependent changes in molecular properties of mitochondrial apoptosis-inducing factor
Inna Y. Churbanova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion
Claudia Zanna et al.
BRAIN (2008)
Multi-target-directed drug design strategy: From a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease
Maria Laura Bolognesi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: Safinamide and coumarin analogs
Claudia Binda et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction
R. R. Ramsay et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage
Lorena Griparic et al.
JOURNAL OF CELL BIOLOGY (2007)
Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B
Dale E. Edmondson et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives:: Insights from molecular modeling studies
Angelica Fierro et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
trans-2-phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1
Dawn M. Z. Schmidt et al.
BIOCHEMISTRY (2007)
Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease
R. Vilar et al.
EUROPEAN JOURNAL OF NEUROLOGY (2007)
Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival
Seongeun Cho et al.
EXPERIMENTAL NEUROLOGY (2007)
CYP-dependent metabolism of PF9601N, a new monoamine oxidase-B inhibitor, by C57BL/6 mouse and human liver microsomes
Stefania Dragoni et al.
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2007)
Development of the new group of indole-derived neuroprotective drugs affecting oxidative stress
S. Stolc et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2006)
Elevated monoamine oxidase A levels in the brain - An explanation for the monoamine imbalance of major depression
Jeffrey H. Meyer et al.
ARCHIVES OF GENERAL PSYCHIATRY (2006)
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors
Laura Novaroli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
MicroRNA regulates the expression of human cytochrome P4501B1
Yuki Tsuchiya et al.
CANCER RESEARCH (2006)
Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis
Eric C. C. Cheung et al.
EMBO JOURNAL (2006)
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
Christian Frezza et al.
CELL (2006)
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1
Naotada Ishihara et al.
EMBO JOURNAL (2006)
Free radical scavenging and antioxidant activities of substituted hexahydropyridoindoles. Quantitative structure-activity relationships
L Rackova et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
The therapeutic potential of monoamine oxidase inhibitors
MBH Youdim et al.
NATURE REVIEWS NEUROSCIENCE (2006)
A QSAR model for in silico screening of MAO-A inhibitors.: Prediction, synthesis, and biological assay of novel coumarins
L Santana et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Phosphorylation of cytochromes P450: First discovery of a posttranslational modification of a drug-metabolizing enzyme
B Oesch-Bartlomowicz et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy
N Joza et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Three-dimensional structure of human monoamine oxidase A (MAO A): Relation to the structures of rat MAO A and human MAO B
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
AIF suppresses chemical stress-induced apoptosis and maintains the transformed state of tumor cells
A Urbano et al.
EMBO JOURNAL (2005)
Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation
VPM van Empel et al.
CIRCULATION RESEARCH (2005)
Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria
L Griparic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease
JW Lustbader et al.
SCIENCE (2004)
A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior
K Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Structural basis of mitochondrial tethering by mitofusin complexes
T Koshiba et al.
SCIENCE (2004)
The machinery of mitochondrial fusion, division, and distribution, and emerging connections to apoptosis
KG Hales
MITOCHONDRION (2004)
Death by design: apoptosis, necrosis and autophagy
AL Edinger et al.
CURRENT OPINION IN CELL BIOLOGY (2004)
AIF deficiency compromises oxidative phosphorylation
N Vahsen et al.
EMBO JOURNAL (2004)
Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms
M Ingelman-Sundberg
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2004)
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis
YJ Lee et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A
S Züchner et al.
NATURE GENETICS (2004)
Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products
Y Nicolet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Compartmentation of glutamine, glutamate, and GABA metabolism in neurons and astrocytes: Functional implications
HS Waagepetersen et al.
NEUROSCIENTIST (2003)
Cytochrome P450-dependent metabolism of l-deprenyl in monkey (Cercopithecus aethiops) and C57BL/6 mouse brain microsomal preparations
S Dragoni et al.
JOURNAL OF NEUROCHEMISTRY (2003)
β-amyloid aggregation induced by human acetylcholinesterase:: inhibition studies
M Bartolini et al.
BIOCHEMICAL PHARMACOLOGY (2003)
l-Deprenyl metabolism by the cytochrome P450 system in monkey (Cercopithecus aethiops) liver microsomes
S Dragoni et al.
XENOBIOTICA (2003)
Molar absorption coefficients for the reduced Ellman reagent: reassessment
P Eyer et al.
ANALYTICAL BIOCHEMISTRY (2003)
Parkinson's disease and CYP2D6 polymorphism in Asian populations: A meta-analysis
AS Persad et al.
NEUROEPIDEMIOLOGY (2003)
The harlequin mouse mutation down-regulates apoptosis-inducing factor
JA Klein et al.
NATURE (2002)
Thermodynamic quantities for the ionization reactions of buffers
RN Goldberg et al.
JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA (2002)
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
C Binda et al.
NATURE STRUCTURAL BIOLOGY (2002)
Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine
MM Mesulam et al.
NEUROSCIENCE (2002)
Butyrylcholinesterase: An important new target in Alzheimer's disease therapy
NH Greig et al.
INTERNATIONAL PSYCHOGERIATRICS (2002)
Parkinson's disease, CYP2D6 polymorphism, and age
H Payami et al.
NEUROLOGY (2001)
NADH oxidase activity of mitochondrial apoptosis-inducing factor
MD Miramar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy
C Delettre et al.
NATURE GENETICS (2000)
Morphologic and biochemical hallmarks of apoptosis
A Saraste et al.
CARDIOVASCULAR RESEARCH (2000)
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