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Current situation and future direction of Newcastle disease vaccines

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Article Infectious Diseases

Chicken ISG12(2) attenuates Newcastle disease virus and enhances the efficiency of Newcastle disease vaccine via activating immune pathways

Haijin Liu et al.

Summary: This research identified chicken interferon-stimulated gene 12-2 as a potential adjuvant that can attenuate the virulence of Newcastle disease virus and increase the immunogenicity of the vaccine strain. It may contribute to the development of efficient poultry vaccines.

TRANSBOUNDARY AND EMERGING DISEASES (2022)

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Genotype VII.1.1-Based Newcastle Disease Virus Vaccines Afford Better Protection against Field Isolates in Commercial Broiler Chickens

Abdelmonem A. A. Dewidar et al.

Summary: This study evaluated the efficacy of two commercial recombinant Newcastle disease virus (NDV) vaccines based on genotype VII.1.1. The results showed that the vaccine based on the VG/GA strain backbone provided superior protection and reduced virus shedding, while the vaccine based on the LaSota strain backbone had a poorer performance. Future research should focus on exploring the cell-mediated immune response induced by the GVII vaccines.

ANIMALS (2022)

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Efficacy of a Turkey Herpesvirus Vectored Newcastle Disease Vaccine against Genotype VII.1.1 Virus: Challenge Route Affects Shedding Pattern

Vilmos Palya et al.

Summary: Control of Newcastle disease heavily relies on vaccination, with the efficacy of the vaccine affecting the level of challenge virus shedding. Vaccination with rHVT-ND vaccine can provide clinical protection against heterologous ND virus strains and significantly reduce challenge virus shedding, with differences in oro-nasal shedding observed between different challenge routes indicating the vaccine induces strong systemic immunity.

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Novel Recombinant Newcastle Disease Virus-Based In Ovo Vaccines Bypass Maternal Immunity to Provide Full Protection from Early Virulent Challenge

Kiril M. Dimitrov et al.

Summary: Newcastle disease remains a significant concern in the poultry industry despite current vaccination efforts. In ovo vaccination using recombinant NDV-vectored vaccines shows promise in overcoming maternal antibody interference and providing early immune protection post-hatch. The experimental vaccines demonstrated reduced post-hatch mortality, early humoral immune response induction, and protection from clinical disease and virus shedding after virulent challenge, highlighting their potential as a valuable tool in Newcastle disease control.

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Comparison of the protective antigen variabilities of prevalent Newcastle disease viruses in response to homologous/heterologous genotype vaccines

Yonghua Li et al.

Summary: The study found that under the pressure of genotype II and VII anti-NDV serum, variations in the F and HN genes of different NDV strains occurred, but there were no significant differences between the two serum groups.

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The Expression of Hemagglutinin by a Recombinant Newcastle Disease Virus Causes Structural Changes and Alters Innate Immune Sensing

Fiona Ingrao et al.

Summary: Recombinant Newcastle disease viruses (rNDV) have been used as bivalent vectors for vaccination against multiple economically important avian pathogens. NDV-vectored vaccines expressing the immunogenic H5 hemagglutinin (rNDV-H5) are considered attractive candidates to protect poultry from both highly pathogenic avian influenza (HPAI) and Newcastle disease (ND). The study compared a rNDV-H5 vaccine and its parental NDV LaSota strain in terms of their structural and functional characteristics, as well as their recognition by the innate immune sensors.Structural analysis of the rNDV-H5 demonstrated a decreased number of fusion (F) and a higher number of hemagglutinin-neuraminidase (HN) glycoproteins compared to NDV LaSota.

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A Novel Recombinant Newcastle Disease Vaccine Improves Post- In Ovo Vaccination Survival with Sustained Protection against Virulent Challenge

Valerie C. Marcano et al.

Summary: The study investigated the efficacy of in ovo vaccination with a specific vaccine against Newcastle disease in chicken embryos, showing that the vaccine provided effective protection, reduced mortality rates, and generated strong immune response against the challenge virus.

VACCINES (2021)

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Phylogenetic relationship and genotype variation of six Newcastle disease viruses isolated from duck in Indonesia

Naimah Putri et al.

Summary: The study aimed to characterize NDV isolates from unvaccinated ducks in Indonesia, revealing various genotypes and pathotypes circulating in the environment and posing a risk of Newcastle disease outbreak. The results showed that some isolates were velogenic viruses while others were lentogenic, underscoring the importance of monitoring and controlling NDV in avian populations.

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Protective efficacy of the Newcastle disease virus genotype VII-matched vaccine in commercial layers

Hesham A. Sultan et al.

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Early Stage Development of a Newcastle Disease Vaccine Candidate in Corn

Naila Shahid et al.

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Epidemiology, control, and prevention of Newcastle disease in endemic regions: Latin America

A. E. Absalon et al.

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Gaya K. Amarasinghe et al.

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Ehud Shahar et al.

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Diagnostic and Vaccination Approaches for Newcastle Disease Virus in Poultry: The Current and Emerging Perspectives

Muhammad Bashir Bello et al.

BIOMED RESEARCH INTERNATIONAL (2018)

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Genetic, antigenic, and pathogenic characteristics of Newcastle disease viruses isolated from geese in China

Qianqian Xu et al.

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION (2017)

Article Biochemistry & Molecular Biology

Chicken interleukin-1β mutants are effective single-dose vaccine adjuvants that enhance mucosal immune response

Wen-Ting Chen et al.

MOLECULAR IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

Effects of Chicken Interferon Gamma on Newcastle Disease Virus Vaccine Immunogenicity

Stivalis Cardenas-Garcia et al.

PLOS ONE (2016)

Article Infectious Diseases

Molecular and antigenic characteristics of Newcastle disease virus isolates from domestic ducks in China

Wei Wu et al.

INFECTION GENETICS AND EVOLUTION (2015)

Article Biotechnology & Applied Microbiology

P and M gene junction is the optimal insertion site in Newcastle disease virus vaccine vector for foreign gene expression

Wei Zhao et al.

JOURNAL OF GENERAL VIROLOGY (2015)

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Efficacy and transmissibility of Newcastle disease I-2 vaccine strain against a field isolate of virulent ND virus (JF820294.1) in village chicken

Hassan Habibi et al.

TROPICAL ANIMAL HEALTH AND PRODUCTION (2015)

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Effects of Newcastle disease virus vaccine antibodies on the shedding and transmission of challenge viruses

Patti J. Miller et al.

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Newcastle disease virus outbreaks: Vaccine mismatch or inadequate application?

Jos C. F. M. Dortmans et al.

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Phylogeny and evolution of Newcastle disease virus genotypes isolated in Asia during 2008-2011

Mohammad Majid Ebrahimi et al.

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Newcastle disease: Evolution of genotypes and the related diagnostic challenges

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INFECTION GENETICS AND EVOLUTION (2010)

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Herd immunity to Newcastle disease virus in poultry by vaccination

Michiel van Boven et al.

AVIAN PATHOLOGY (2008)

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Characterization of a recombinant Newcastle disease virus vaccine strain

Sun-Hee Cho et al.

CLINICAL AND VACCINE IMMUNOLOGY (2008)

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FluBlok, a recombinant hemagglutinin influenza vaccine

Manon M. J. Cox et al.

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Newcastle disease in geese: natural occurrence and experimental infection

HQ Wan et al.

AVIAN PATHOLOGY (2004)

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Phylogenetic analysis of Newcastle disease virus genotypes isolated in Japan

M Mase et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2002)

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Newcastle disease virus: macromolecules and opportunities

K Yusoff et al.

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