Fluid Resuscitation With Lactated Ringer's Solution Versus Normal Saline in Acute Pancreatitis A Systematic Review and Meta-Analysis of Randomized Trials

ObjectivesWe aimed to perform a systematic review and meta-analysis of randomized controlled trials to summarize the overall association between the choice of fluid (lactated Ringer's [LR] or normal saline [NS]) and clinical outcomes in patients with acute pancreatitis.MethodsA systematic literature search was performed in electronic databases to identify eligible randomized controlled trials. Meta-analyses with the random-effects and IVhet models were used to estimate the pooled odds ratio (OR) for outcomes of interest with the administration of LR relative to NS, at 95% confidence intervals (CIs).ResultsThere was a significant reduction in the odds of intensive care unit admission and development of local complications, respectively, with the administration of LR among hospitalized patients with acute pancreatitis relative to administration of NS (pooled ORs, 0.33 [95% CI, 0.13-0.81] and 0.43 [95% CI, 0.21-0.89], respectively).ConclusionsOur findings are able to assist clinicians in the navigation of the proper choice of fluid in patients with acute pancreatitis.

Automated summary

This study conducted a systematic review and meta-analysis to explore the association between the choice of fluid (lactated Ringer's or normal saline) and clinical outcomes in patients with acute pancreatitis. The findings suggest that the administration of lactated Ringer's fluid may reduce the odds of intensive care unit admission and local complications in hospitalized patients with acute pancreatitis compared to normal saline.