期刊
ACS CATALYSIS
卷 -, 期 -, 页码 15638-15647出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.2c0525115638
关键词
nickel catalysis; selective catalysis; hydrofunctionalization; 3-dienes; reaction mechanism
资金
- Swiss National Science Foundation
- University of Geneva
- [200021_188490]
Ni-catalyzed enantioselective hydrofunctionalizations of conjugated dienes are challenging reactions that require addressing multiple aspects of selective catalysis. However, the value-added nature of the obtained chiral derivatives and the use of an earth-abundant transition metal have led to increased interest in this field. This Perspective provides an overview of the developments in this area, emphasizing the nature of the hydrofunctionalization agent.
Ni-catalyzed enantioselective hydrofunctionalizations of conjugated dienes are particularly demanding reactions to devise because they require not only addressing the inherent challenges associated with the development of an enantioselective transformation but also overcoming all other aspects of selective catalysis (chemoselectivity, regioselectivity, diastereoselectivity, etc.). However, the value-added nature of the chiral allylic and homoallylic derivatives obtained by these methods, the lack of efficient alternatives, and the use of an earth-abundant first-row transition metal have led to renewed interest over the past decade. In this Perspective, we give an overview of the developments in this field, from the original findings (often dating back to the last century) to the most recent contributions. Emphasis is placed on the nature of the hydrofunctionalization agent (C(sp), C(sp2), C(sp3), N, P, or O).
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