The Crosstalk between the Blood-Brain Barrier Dysfunction and Neuroinflammation after General Anaesthesia

As we know, with continuous medical progress, the treatment of many diseases can be conducted via surgery, which often relies on general anaesthesia for its satisfactory performance. With the widespread use of general anaesthetics, people are beginning to question the safety of general anaesthesia and there is a growing interest in central nervous system (CNS) complications associated with anaesthetics. Recently, abundant evidence has suggested that both blood-brain barrier (BBB) dysfunction and neuroinflammation play roles in the development of CNS complications after anaesthesia. Whether there is a crosstalk between BBB dysfunction and neuroinflammation after general anaesthesia, and whether this possible crosstalk could be a therapeutic target for CNS complications after general anaesthesia needs to be clarified by further studies.

Automated summary

With the widespread use of general anaesthetics, concerns about the safety and complications of general anaesthesia have arisen. Recent evidence suggests that both blood-brain barrier dysfunction and neuroinflammation play important roles in the development of central nervous system complications after anaesthesia. Further studies are needed to clarify the possible crosstalk between BBB dysfunction and neuroinflammation and explore their potential as therapeutic targets for CNS complications after general anaesthesia.