期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
卷 178, 期 -, 页码 145-155出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpc.2015.09.013
关键词
Chromium; Chromate; Sea turtle; Hawksbill; Genotoxicity; Marine pollution; Skin
资金
- Vieques Conservation and Historical Trust
- TICATOVE
- Vieques Office of the United States Fish and Wildlife Service
- National Institute of Environmental Health Sciences of the National Institutes of Health [R01ES016893]
- Maine Space Grant Consortium [SG-14-29]
- Ocean Foundation
- Henry Foundation
- Curtis and Edith Munson Foundation
Chromium is both a global marine pollutant and a known human health hazard. In this study, we compare the cytotoxicity and genotoxicity of both soluble and particulate chromate in human and hawksbill sea turtle (Eretmochelys imbricata) skin fibroblasts. Our data show that both soluble and particulate Cr(VI) induce concentration-dependent increases in cytotoxicity, genotoxicity, and intracellular Cr ion concentrations in both human and hawksbill sea turtle fibroblasts. Based on administered concentration, particulate and soluble Cr(VI) were more cytotoxic and clastogenic to human cells than sea turtle cells. When the analysis was based on the intracellular concentration of Cr, the data showed that the response of both species was similar. The one exception was the cytotoxicity of intracellular Cr ions from soluble Cr(VI), which caused more cytotoxicity in sea turtle cells (LC50 = 271 mu M) than that of human cells (LC50 = 471 mu M), but its clastogenicity was similar between the two species. Thus, adjusting for differences in uptake indicated that the explanation for the difference in potency was mostly due to uptake rather than differently affected mechanisms. Overall these data indicate that sea turtles may be a useful sentinel for human health responses to marine pollution. (C) 2015 Elsevier Inc. All rights reserved.
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