The central role of the gut in intensive care

Critically ill patients undergo early impairment of their gut microbiota (GM) due to routine antibiotic therapies and other environmental factors leading to intestinal dysbiosis. The GM establishes connections with the rest of the human body along several axes representing critical inter-organ crosstalks that, once disrupted, play a major role in the pathophysiology of numerous diseases and their complications. Key players in this communication are GM metabolites such as short-chain fatty acids and bile acids, neurotransmitters, hormones, interleukins, and toxins. Intensivists juggle at the crossroad of multiple connections between the intestine and the rest of the body. Harnessing the GM in ICU could improve the management of several challenges, such as infections, traumatic brain injury, heart failure, kidney injury, and liver dysfunction. The study of molecular pathways affected by the GM in different clinical conditions is still at an early stage, and evidence in critically ill patients is lacking. This review aims to describe dysbiosis in critical illness and provide intensivists with a perspective on the potential as adjuvant strategies (e.g., nutrition, probiotics, prebiotics and synbiotics supplementation, adsorbent charcoal, beta-lactamase, and fecal microbiota transplantation) to modulate the GM in ICU patients and attempt to restore eubiosis.

Automated summary

Critically ill patients often experience early disruption of their gut microbiota, leading to intestinal dysbiosis. The gut microbiota plays a crucial role in inter-organ communication through various molecular pathways, but the understanding of its effects in different clinical conditions and critically ill patients is still limited. Utilizing the gut microbiota as adjuvant strategies in the ICU could potentially improve the management of infections, brain injury, heart failure, kidney injury, and liver dysfunction. However, more research is needed to fully understand the molecular pathways and evidence is lacking in critically ill patients.