A glance at transient hyperammonemia of the newborn: Pathophysiology, diagnosis, and treatment: A review

Hyperammonemia is the excessive accumulation of ammonia in the blood, and is usually defined as a plasma level above 100 mu mol/L in neonates or above 50 mu mol/L in term infants, children, and adolescents. Patients with hyperammonemia usually experience life-threatening neuropsychiatric symptoms, especially newborns. It is routinely caused by inherited metabolic diseases and also by acquired disorders, such as liver failure, portosystemic shunting, gastrointestinal hemorrhage, ureterosigmoidostomy, renal tubular acidosis, hypoxic ischemic encephalopathy, infections with urea-metabolizing organisms, and some drugs. Transient hyperammonemia of the newborn (THAN) is a special type of hyperammonemia acknowledged in the field of metabolic disease as an inwell-defined or well-understood entity, which can be diagnosed only after the exclusion of genetic and acquired causes of hyperammonemia. Although the prognosis for THAN is good, timely identification and treatment are essential. Currently, THAN is underdiagnosed and much less is mentioned for early diagnosis and vigorous treatment. Herein, we present common themes that emerge from the pathogenesis, diagnosis, and management of THAN, based on current evidence. When a newborn presents with sepsis, intracranial hemorrhage, or asphyxia that cannot explain coma and seizures, doctors should always keep this disease in mind.

Automated summary

Hyperammonemia refers to excessive accumulation of ammonia in the blood, leading to life-threatening neuropsychiatric symptoms. It can be caused by inherited metabolic diseases, liver failure, gastrointestinal bleeding, and other factors. Transient hyperammonemia of the newborn is a condition that requires further evaluation for diagnosis, and timely identification and treatment are crucial.