期刊
CURRENT RESEARCH IN FOOD SCIENCE
卷 5, 期 -, 页码 1976-1984出版社
ELSEVIER
DOI: 10.1016/j.crfs.2022.10.021
关键词
Obesity; Acetic acid; Bile acids; Antagonist; FXR
资金
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing
- [81803214]
- [81800750]
- [82003432]
- [7212143]
This study found that high-fat diet-induced obesity disrupts bile acids balance, providing evidence for the potential use of acetic acid as a treatment. Acetic acid supplementation promotes the synthesis of specific types of bile acids in the liver and reduces their excretion in feces, thus restoring bile acids balance.
Vinegar is widely used in Chinese diet as a traditional condiment, and its functional component acetic acid has been proposed to prevent obesity, while its mechanism is still unclear. Bile acids (BAs) have been reported to have a protective effect on obesity. This study demonstrated that high-fat diet induced obesity (DIO) seriously disturbed BAs balance by significantly decreasing hepatic BAs synthesis and increasing fecal BAs excretion. However, acetate supplemented in the high-fat diet can restore BAs balance by mainly promoting hepatic taurine conjugated BAs (tauro-BAs) synthesis and decreasing fecal tauro-BAs excretion. The tauro-BAs, as the antagonists, inhibited the intestinal-liver farnesoid X receptor (FXR)-fibroblast growth factor 15 (FGF15)-FGF receptor 4 (FGFR4) signaling pathway, and negatively regulated the production of hepatic BAs. Present study provided important clues for further investigation of the mechanism of acetic acid inhibiting DIO.
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