期刊
FRONTIERS IN IMMUNOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.1082055
关键词
Treg; tissue; epigenetics; methylation; homeostasis
类别
资金
- German Research Foundation
- [318346496]
- [SFB1292/2 TP19]
Regulatory T cells in non-lymphoid tissues play a critical role in maintaining self-tolerance, promoting organ homeostasis, and tissue repair. This review summarizes recent research on the differentiation of tissue Treg cells and highlights the importance of epigenetic remodeling in this process.
Regulatory T cells in non-lymphoid tissues are not only critical for maintaining self-tolerance, but are also important for promoting organ homeostasis and tissue repair. It is proposed that the generation of tissue Treg cells is a stepwise, multi-site process, accompanied by extensive epigenome remodeling, finally leading to the acquisition of unique tissue-specific epigenetic signatures. This process is initiated in the thymus, where Treg cells acquire core phenotypic and functional properties, followed by a priming step in secondary lymphoid organs that permits Treg cells to exit the lymphoid organs and seed into non-lymphoid tissues. There, a final specialization process takes place in response to unique microenvironmental cues in the respective tissue. In this review, we will summarize recent findings on this multi-site tissue Treg cell differentiation and highlight the importance of epigenetic remodeling during these stepwise events.
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