期刊
RESPIRATORY RESEARCH
卷 23, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12931-022-02283-4
关键词
COVID-19; Auto-antibodies; Type I interferon; Anti-interferon antibodies; Acute respiratory failure
资金
- National Heart, Lung and Blood Institute
- Chan Zuckerberg Biohub [R35 HL140026, K23HL138461-01A1]
Auto-antibodies to type I interferons are uncommon in critically ill patients with acute respiratory failure due to causes other than COVID-19. These auto-antibodies are associated with different clinical presentations and are rarely found in patients with viral infections.
Auto-antibodies (Abs) to type I interferons (IFNs) are found in up to 25% of patients with severe COVID-19, and are implicated in disease pathogenesis. It has remained unknown, however, whether type I IFN auto-Abs are unique to COVID-19, or are also found in other types of severe respiratory illnesses. To address this, we studied a prospective cohort of 284 adults with acute respiratory failure due to causes other than COVID-19. We measured type I IFN auto-Abs by radio ligand binding assay and screened for respiratory viruses using clinical PCR and metagenomic sequencing. Three patients (1.1%) tested positive for type I IFN auto-Abs, and each had a different underlying clinical presentation. Of the 35 patients found to have viral infections, only one patient tested positive for type I IFN auto-Abs. Together, our data suggest that type I IFN auto-Abs are uncommon in critically ill patients with acute respiratory failure due to causes other than COVID-19.
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