期刊
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
卷 40, 期 3, 页码 278-282出版社
ALLERGY IMMUNOL SOC THAILAND
DOI: 10.12932/ap-290419-0551
关键词
Haploidentical transplantation; Hematopoietic stem cell transplantation; Chronic granulomatous disease; Cyclophosphamide; Graft-Versus-Host Disease
资金
- Ramathibodi Foundation
- Mahidol University Research Grant
Haploidentical HSCT with PTCY may be an effective treatment option for children with CGD.
Background: HLA-matched hematopoietic stem cell transplantation (HSCT) is the curative treatment for chronic granulomatous disease (CGD). Objective: To report a case of X-linked CGD with active infection successfully treated by haploidentical HSCT with post-transplant high dose cyclophosphamide (PTCY). Methods: A 5-year-old Thai boy with CGD was undergone for haploidentical HSCT using PTCY with correction of the phagocytic function. He presented with Chromobacterium violaceum liver abscess at the age of 9 months and experienced recurrent perianal abscess and invasive pulmonary aspergillosis even receiving antimicrobial prophylaxis. PTCY was given on day 3 and 4, after CD34+ cells infusion. Results: The peripheral blood-nucleated cell chimerism showed 100% on day 16 and remained 100%. Dihydrorhodamine (DHR) assay on day 108 and day 214 showed normal results. Currently at 22 months post HSCT, he does not receive antibiotic and anti-fungal prophylaxis. Conclusions: Haploidentical HSCT with PTCY could be an effective treatment option for children with CGD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据