4.5 Review

Dyskinesia and Parkinson's disease: animal model, drug targets, and agents in preclinical testing

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys

Marc Morissette et al.

Summary: Inflammatory markers were found in the brains of Parkinson's disease patients. The study showed that MPEP reduced the development of L-Dopa-induced dyskinesias (LID) in MPTP-lesioned monkeys and decreased inflammatory markers in the brain. The results demonstrated increased inflammatory markers in the basal ganglia associated with LID and revealed the potential of MPEP in reducing LID and inflammatory response.
Article Neurosciences

Non-dopaminergic approaches to the treatment of motor complications in Parkinson's disease

M. Angela Cenci et al.

Summary: Dopamine replacement therapy is the most effective treatment for Parkinson's disease, but it is limited by its side effects. Recent evidence suggests that altered dopamine transmission affects non-dopaminergic neurotransmitter systems in the brain. Researchers are exploring drugs that target non-dopaminergic receptors to improve the side effects of dopamine replacement therapy. This review discusses the different non-dopaminergic targets that have been studied, with a particular focus on modulators of glutamatergic and serotonergic transmission.

NEUROPHARMACOLOGY (2022)

Article Behavioral Sciences

The multimodal serotonin compound Vilazodone alone, but not combined with the glutamate antagonist Amantadine, reduces L-DOPA-induced dyskinesia in hemiparkinsonian rats

Sophie R. Cohen et al.

Summary: This study investigated the effects of the combination of Vilazodone (VZD), a 5-HT transport blocker, and Amantadine (AMAT), an NMDA glutamate antagonist, on Parkinson's disease (PD) motor disorders. The results showed that low doses of VZD and AMAT combined with L-DOPA can reduce dyskinesia and maintain treatment efficacy.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2022)

Article Neurosciences

The effects of Vilazodone, YL-0919 and Vortioxetine in hemiparkinsonian rats

Samantha Smith et al.

Summary: Parkinson's disease is a neurodegenerative disease characterized by motor deficits, and chronic use of L-DOPA can lead to abnormal involuntary movements. This study demonstrates that compounds selective for 5-HT1A/SERT target sites, such as Vilazodone and Vortioxetine, can reduce L-DOPA-induced dyskinesia without compromising the pro-motor efficacy of L-DOPA. These findings suggest these compounds could be potential adjunct therapeutics for managing L-DOPA-induced dyskinesia in Parkinson's patients.

PSYCHOPHARMACOLOGY (2022)

Review Geriatrics & Gerontology

Microvascular Changes in Parkinson's Disease- Focus on the Neurovascular Unit

Gesine Paul et al.

Summary: Vascular alterations are commonly observed in various neurodegenerative diseases, including Parkinson's disease (PD). This review examines the evidence for different vascular changes in PD patients and animal models, ranging from pericyte activation and blood-brain barrier (BBB) disruption to compensatory angiogenesis and vascular rarefaction. The review also highlights the potential role of perivascular inflammation and metabolic disease in these vascular alterations. Understanding the contribution of vascular events to PD pathogenesis could lead to the development of novel therapeutic strategies, such as modulating the BBB and its signaling at the interface between the blood and the brain.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Editorial Material Neurosciences

Sex Differences in Parkinson's Disease: From Bench to Bedside

Maria Claudia Russillo et al.

Summary: This review examines the gender differences in Parkinson's Disease (PD), covering biomarkers, genetic factors, symptoms, and treatment options. The findings confirm the existence of disparities between men and women in PD and provide new insights into the potential causes and management of the disease. The objective is to develop tailored interventions based on a better understanding of sex and gender differences in PD.

BRAIN SCIENCES (2022)

Review Neurosciences

Shedding light on dyskinesias

Ivan Castela et al.

Summary: The study reviews the dopamine replacement therapy with L-DOPA commonly used in the treatment of Parkinson's disease, focusing on the role of the striatal direct and indirect pathways in the pathological motor consequences. It discusses how alterations in the efferent circuitry of the striatum and changes in synaptic plasticity and firing patterns can contribute to dyskinesia development. Recent findings suggest that an imbalance in the activity between both striatal pathways is sufficient to cause dyskinesia in both rodent and primate models of Parkinson's disease.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

Article Pharmacology & Pharmacy

NEWLY SYNTHESIZED AMANTADINE DERIVATIVE: SAFETY AND NEUROPHARMACOLOGICAL ACTIVITY

Ivanka Stankova et al.

Summary: The newly synthesized amantadine derivative Tyr-Am showed the best toxicological characteristics in male ICR mice, significantly improved neuromuscular performance and spatial memory, and demonstrated better therapeutic index and efficacy against Parkinson's disease compared to amantadine.

FARMACIA (2021)

Article Multidisciplinary Sciences

Human α-synuclein overexpression in a mouse model of Parkinson's disease leads to vascular pathology, blood brain barrier leakage and pericyte activation

Osama Elabi et al.

Summary: The pathological hallmark of Parkinson's disease is the formation of Lewy bodies containing alpha-synuclein, but microvascular alterations have also been linked to neurodegeneration in PD. Using a human alpha-synuclein overexpression mouse model, researchers demonstrated compromised blood-brain barrier integrity, dynamic changes in vessel morphology, and activation of pericytes, supporting the occurrence of vascular pathology as an important aspect in PD. This model provides a powerful tool to investigate disease-modifying factors and guide the development of new treatments for Parkinson's disease.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Role of 5-HT1A Receptor in Vilazodone-Mediated Suppression of L-DOPA-Induced Dyskinesia and Increased Responsiveness to Cortical Input in Striatal Medium Spiny Neurons in an Animal Model of Parkinson's Disease

Feras Altwal et al.

Summary: Research has shown that vilazodone may reduce dyskinesia in patients with Parkinson's disease without interfering with the prokinetic effects of L-DOPA, possibly through its action on 5-HT receptors.

MOLECULES (2021)

Review Clinical Neurology

Genetic variants in levodopa-induced dyskinesia (LID): A systematic review and meta-analysis

Marika Falla et al.

Summary: This study systematically reviewed 33 studies investigating genetic factors in Parkinson’s disease dyskinesia, revealing that out of 37 genes analyzed, 22 were possibly associated with dyskinesia. Despite differences, the meta-analysis failed to demonstrate any specific gene’s association with LID susceptibility. Additional research is needed to clarify the role of genetic factors in LID susceptibility.

PARKINSONISM & RELATED DISORDERS (2021)

Article Neurosciences

Neuroinflammation and L-dopa-induced abnormal involuntary movements in 6-hydroxydopamine-lesioned rat model of Parkinson's disease are counteracted by combined administration of a 5-HT1A/1B receptor agonist and A2A receptor antagonist

Annalisa Pinna et al.

Summary: The study found that the combination of L-dopa, eltoprazine, and preladenant could potentially delay the onset of dyskinesia, maintain the efficacy of L-dopa, and reduce neuroinflammation markers in the nigrostriatal system of 6-OHDA-lesioned rats.

NEUROPHARMACOLOGY (2021)

Article Medicine, Research & Experimental

D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson's disease

Irene Sebastianutto et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Neurosciences

Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia

Rita L. Vaz et al.

NEUROSCIENCE (2020)

Article Pharmacology & Pharmacy

6-Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in thesubstantia nigra pars reticulata

Sergio Vegas-Suarez et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

Article Medicine, Research & Experimental

Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine

Weixing Shen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Clinical Neurology

Research advances on L-DOPA-induced dyskinesia: from animal models to human disease

Xi Chen et al.

NEUROLOGICAL SCIENCES (2020)

Article Neurosciences

μ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease

Erwan Bezard et al.

JOURNAL OF NEUROSCIENCE (2020)

Article Medicine, Research & Experimental

L-DOPA-Induced Dyskinesia in a Genetic Drosophila Model of Parkinson's Disease

Joshua A. Blosser et al.

EXPERIMENTAL NEUROBIOLOGY (2020)

Article Biochemistry & Molecular Biology

The effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice

Hiromi Sano et al.

NEUROCHEMISTRY INTERNATIONAL (2019)

Review Pharmacology & Pharmacy

Pathophysiological clues to therapeutic applications of glutamate mGlu5 receptor antagonists in levodopa-induced dyskinesia

Shayan Pourmirbabaei et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Review Neurosciences

Parkinson's Disease in Women and Men: What's the Difference?

Silvia Cerri et al.

JOURNAL OF PARKINSONS DISEASE (2019)

Review Clinical Neurology

Non-human primate models of PD to test novel therapies

Marc Morissette et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

Review Clinical Neurology

Levodopa Treatment and Dendritic Spine Pathology

Haruo Nishijima et al.

MOVEMENT DISORDERS (2018)

Review Clinical Neurology

Signal transduction in L-DOPA-induced dyskinesia: from receptor sensitization to abnormal gene expression

Giada Spigolon et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

Review Clinical Neurology

Synaptic plasticity and levodopa-induced dyskinesia: electrophysiological and structural abnormalities

Barbara Picconi et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

Review Pharmacology & Pharmacy

Predictive Value of Parkinsonian Primates in Pharmacologic Studies: A Comparison between the Macaque, Marmoset, and Squirrel Monkey

Nicolas Veyres et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)

Review Clinical Neurology

Animal Models of L-Dopa-Induced Dyskinesia in Parkinson's Disease

M. Angela Cenci et al.

MOVEMENT DISORDERS (2018)

Article Clinical Neurology

The effect of mianserin on the severity of psychosis and dyskinesia in the parkinsonian marmoset

Adjia Hamadjida et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2018)

Article Pharmacology & Pharmacy

Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia

Elizabeth F. Brigham et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)

Article Clinical Neurology

An mGlu4-Positive Allosteric Modulator Alleviates Parkinsonism in Primates

Delphine Charvin et al.

MOVEMENT DISORDERS (2018)

Article Pharmacology & Pharmacy

PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders

Fabiana Nunez et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Medicine, Research & Experimental

Chemogenetic stimulation of striatal projection neurons modulates responses to Parkinson's disease therapy

Cristina Alcacer et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Neurosciences

Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias

Jennifer Stanic et al.

NEUROBIOLOGY OF DISEASE (2017)

Article Medicine, General & Internal

Parkinson disease

Werner Poewe et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Review Neurosciences

Maladaptive Synaptic Plasticity in L-DOPA-Induced Dyskinesia

Qiang Wang et al.

FRONTIERS IN NEURAL CIRCUITS (2016)

Review Neurosciences

Evaluation of Models of Parkinson's Disease

Shail A. Jagmag et al.

FRONTIERS IN NEUROSCIENCE (2016)

Article Behavioral Sciences

A new quantitative rating scale for dyskinesia in nonhuman primates

Lisa F. Potts et al.

BEHAVIOURAL PHARMACOLOGY (2015)

Review Clinical Neurology

Disease-Modifying Strategies for Parkinson's Disease

Lorraine V. Kalia et al.

MOVEMENT DISORDERS (2015)

Review Neurosciences

Modeling dyskinesia in animal models of Parkinson disease

Nicolas Morin et al.

EXPERIMENTAL NEUROLOGY (2014)

Review Neurosciences

Modeling Parkinson's disease in monkeys for translational studies, a critical analysis

Lisa F. Potts et al.

EXPERIMENTAL NEUROLOGY (2014)

Article Clinical Neurology

Synergistic antidyskinetic effects of topiramate and amantadine in animal models of Parkinson's disease

Christopher Kobylecki et al.

MOVEMENT DISORDERS (2011)

Article Clinical Neurology

Maladaptive Plasticity of Serotonin Axon Terminals in Levodopa-Induced Dyskinesia

Daniella Rylander et al.

ANNALS OF NEUROLOGY (2010)

Article Clinical Neurology

L-DOPA-induced dyskinesia: cellular mechanisms and approaches to treatment

M. Angela Cenci

PARKINSONISM & RELATED DISORDERS (2007)

Review Neurosciences

The 6-hydroxydopamine model of Parkinson's disease

Nicola Simola et al.

NEUROTOXICITY RESEARCH (2007)

Review Neurosciences

Metabotropic glutamate receptors in the basal ganglia motor circuit

PJ Conn et al.

NATURE REVIEWS NEUROSCIENCE (2005)

Review Clinical Neurology

Nondopaminergic mechanisms in levodopa-induced dyskinesia

JA Brotchie

MOVEMENT DISORDERS (2005)

Review Neurosciences

Functional changes of the basal ganglia circuitry in Parkinson's disease

F Blandini et al.

PROGRESS IN NEUROBIOLOGY (2000)