期刊
FERMENTATION-BASEL
卷 8, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/fermentation8120670
关键词
biorefinery; food waste; cheese whey; acid hydrolysis; fermentation; Cyclosporin A
资金
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT (MSIT)
- [NRF-2020R1C1C1005060]
Food waste-based biorefineries are important for achieving a sustainable circular economy. This study utilized cheese whey powder to produce cyclosporin A and showed the potential of using cheese whey powder as a sustainable feedstock for biorefineries.
Food waste-based biorefineries are considered an essential concept for the implementation of a sustainable circular economy. In this study, cheese whey powder (CWP), a dairy industry waste, was utilized to produce cyclosporin A (CsA). As it is difficult to valorize CWP because its components vary depending on the origin, a process for sugar conversion via acid hydrolysis was designed to obtain reproducible results using refined whey powder (WP) of a consistent quality. Acid hydrolysis was carried out using 2% (w/w) HCl and biomass loading of 50 g/L at 121 degrees C for 20 min. CWP hydrolysates were utilized to ferment Tolypocladium inflatum ATCC 34921. CsA production was found to be 51.3 mg/L at 12 days, a 1.4-fold increase compared to the control (commercial glucose, 36.3 mg/L). Our results showed that 100 g CWP can be converted to 81.8 mg of CsA. This finding demonstrated that CWP can be used as a sustainable feedstock for biorefineries.
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