4.0 Article

Safety and biomarker effects of candesartan in non-hypertensive adults with prodromal Alzheimer's disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

Association of Antihypertensives That Stimulate vs Inhibit Types 2 and 4 Angiotensin II Receptors With Cognitive Impairment

Zachary A. Marcum et al.

Summary: The use of antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors is associated with a lower risk of dementia. This study examines the impact of exclusively stimulating vs inhibiting antihypertensive medication regimens on mild cognitive impairment (MCI) or dementia. The findings suggest that prevalent users of stimulating medications had lower rates of cognitive impairment.

JAMA NETWORK OPEN (2022)

Review Cardiac & Cardiovascular Systems

The renin-angiotensin system and the brain

M. Molina-Van den Bosch et al.

Summary: This article summarizes the important role of the renin-angiotensin-aldosterone system in blood pressure regulation, as well as its impact on neuroprotection and cognition.

HIPERTENSION Y RIESGO VASCULAR (2021)

Article Clinical Neurology

Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial

Patrick Gavin Kehoe et al.

Summary: The study investigated the impact of losartan on brain volume loss in clinically diagnosed mild-to-moderate Alzheimer's disease patients. The results showed that 12 months of losartan treatment did not significantly reduce brain atrophy. Additionally, there were no significant differences in total volume reduction and adverse events between the treatment and placebo groups.

LANCET NEUROLOGY (2021)

Article Clinical Neurology

The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer's disease: the importance of blood-brain barrier penetration and APOE ε4 carrier status

Michael Ouk et al.

Summary: Among individuals with Alzheimer's disease who do not carry the APOEε4 gene, the use of angiotensin receptor blockers (ARBs) was found to be associated with better preservation of delayed recall memory and attention/psychomotor processing speed over time compared to angiotensin-converting enzyme inhibitors (ACE-Is) that do not cross the blood-brain barrier.

ALZHEIMERS RESEARCH & THERAPY (2021)

Article Geriatrics & Gerontology

Associations between brain amyloid accumulation and the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers

Michael Ouk et al.

Summary: This study suggests that ARBs may be more effective than ACE-Is in protecting against memory decline by slowing amyloid-beta accumulation in certain brain regions. Differences in amyloid-beta accumulation rates between ARB and ACE-I users may be influenced by apolipoprotein E epsilon 4 carrier status. Further studies and clinical trials are needed to confirm the potential benefits of ARBs in Alzheimer's disease prevention and treatment.

NEUROBIOLOGY OF AGING (2021)

Article Neurosciences

Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel Pathways

Peter J. Attilio et al.

Summary: Studies have shown that angiotensin receptor blockers such as candesartan can improve recovery from traumatic brain injury in mice by affecting various signaling pathways and gene expression. Transcriptomic profiling revealed that candesartan treatment altered genes involved in different processes like angiogenesis, inflammation, and extracellular matrix regulation.

FRONTIERS IN NEUROSCIENCE (2021)

Article Neurosciences

Cerebrospinal Fluid Changes in the Renin-Angiotensin System in Alzheimer's Disease

Patrick G. Kehoe et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Neurosciences

Angiotensin-III is Increased in Alzheimer's Disease in Association with Amyloid-β and Tau Pathology

Patrick Gavin Kehoe et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Article Clinical Neurology

Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study

Jessica Mira Gabin et al.

ALZHEIMERS RESEARCH & THERAPY (2017)

Article Cell Biology

Candesartan Improves Ischemia-Induced Impairment of the Blood-Brain Barrier In Vitro

Gohei So et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2015)

Article Clinical Neurology

Special Series Introduction: NIH EXAMINER and the Assessment of Executive Functioning

Joel H. Kramer

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2014)

Article Clinical Neurology

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

Chun-Fang Xia et al.

ALZHEIMERS & DEMENTIA (2013)

Article Pharmacology & Pharmacy

Angiotensin (1-7) and other Angiotensin Peptides

Mitsuru Ohishi et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

Review Neurosciences

FreeSurfer

Bruce Fischl

NEUROIMAGE (2012)

Article Engineering, Biomedical

Symmetric geometric transfer matrix partial volume correction for PET imaging: principle, validation and robustness

Mike Sattarivand et al.

PHYSICS IN MEDICINE AND BIOLOGY (2012)

Review Pharmacology & Pharmacy

Role of angiotensin II receptor subtype activation in cognitive function and ischaemic brain damage

Masatsugu Horiuchi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Clinical Neurology

Alzheimer's Disease Neuroimaging Initiative (ADNI) Clinical characterization

R. C. Petersen et al.

NEUROLOGY (2010)

Article Clinical Neurology

Cerebrospinal Fluid Biomarker Signature in Alzheimer's Disease Neuroimaging Initiative Subjects

Leslie M. Shaw et al.

ANNALS OF NEUROLOGY (2009)

Article Cell Biology

Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery

Julius Benicky et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2009)

Review Pharmacology & Pharmacy

The renin-angiotensin systems: Evolving pharmacological perspectives for cerebroprotection

L Magy et al.

CURRENT PHARMACEUTICAL DESIGN (2005)

Article Clinical Neurology

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

WE Klunk et al.

ANNALS OF NEUROLOGY (2004)

Article Peripheral Vascular Disease

Is the angiotensin II type 2 receptor cerebroprotective?

A Fournier et al.

CURRENT HYPERTENSION REPORTS (2004)

Review Biochemistry & Molecular Biology

The brain renin-angiotensin system: location and physiological roles

MJ McKinley et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2003)

Article Psychology, Clinical

Memory and motor skill components of the WAIS-III Digit Symbol-Coding subtest

DS Kreiner et al.

CLINICAL NEUROPSYCHOLOGIST (2001)