期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 26, 期 10, 页码 897-909出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14728222.2022.2157261
关键词
Angiotensin converting enzyme 2; angiotensin converting enzyme inhibitor; angiotensin receptor blocker; gastrointestinal tract; inflammatory bowel disease; renin angiotensin system
This review summarizes the current understanding of the physiological mechanism of the renin-angiotensin system in inflammatory bowel disease and explores its potential therapeutic implications.
IntroductionThe renin-angiotensin system (RAS) is an important homeostatic pathway, with emerging evidence for the impact of its components on inflammation and fibrosis in gastrointestinal tissues. This review aims to review current knowledge of the physiological mechanism of RAS in inflammatory bowel disease (IBD), and potential therapeutic implications.Areas coveredAn extensive online literature review including Pubmed, Medline, and Google Scholar was undertaken. Discussion on the components of the RAS, localization, and physiological functions in the gastrointestinal tract, preclinical, and clinical data in IBD, and the relation with SARS-Cov-2 are covered in this review.Expert OpinionRAS inhibition may have a role as anti-fibrotic adjunct therapy. Targeting the local gastrointestinal RAS with novel modes of delivery may be a target for future therapeutics for IBD, given the widespread availability and safety of current options as utilized in other diseases. Further insight into the mechanism and downstream effects of gastrointestinal ACE2 may lead to a better understanding of the pathogenesis of IBD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据