期刊
CHINESE JOURNAL OF PHYSIOLOGY
卷 65, 期 4, 页码 159-170出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0304-4920.354804
关键词
Addiction; cocaine dose; retrieval-extinction; reconsolidation-update; extinction-facilitation; relapse
类别
资金
- Ministry of Science and Technology (MOST) in Taiwan [104-2410-H-006-025-MY3, 105-2410-H-006-019-MY2]
The retrieval-extinction (R-E) procedure, a noninvasive behavioral intervention, has gained much attention for targeting the reconsolidation of maladaptive memories. However, recent findings suggest that the cause and consequence of R-E may be more complex than previously thought. Two potential mechanisms, extinction-facilitation and reconsolidation-update hypotheses, have been proposed. This study systematically examined the efficacy of extinction (E), R-E, and reversed extinction-retrieval (E-R) procedures and found that the dose of cocaine is a crucial factor determining the effectiveness of these interventions.
As a noninvasive behavioral intervention, the retrieval-extinction (R-E) procedure has drawn much research attention for its capacity to target the reconsolidation of maladaptive memories. However, later research findings suggest that the cause and consequence of R-E may be more complicated than previously suggested. For example, the R-E procedure could increase an animal's motivation for drug-seeking under certain circumstances, and the reversed extinction-retrieval (E-R) procedure could also suppress the drug memory. Two possible mechanisms underlying the R-E procedure have been proposed: the reconsolidation-update and extinction-facilitation hypotheses. To elucidate the paradoxical prior findings and examine these two hypotheses, we systematically examined the efficacy of the extinction (E), R-E, and E-R procedures in mice's low-dose versus high-dose cocaine-induced conditioned place preference (CPP) memory. We showed that the dose of cocaine is a crucial determinant of the efficacy of the three behavioral interventions. The E procedure exerted a long-lasting suppression of the low-dose cocaine CPP memory, while the R-E procedure induced more memory defects than the E and E-R procedures in its long-term suppression of the high-dose cocaine CPP memory. It warrants further investigation of whether the R-E procedure's underlying neurochemical and molecular mechanisms differ from the E and E-R procedures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据