期刊
AMERICAN JOURNAL OF CANCER RESEARCH
卷 12, 期 11, 页码 5074-5084出版社
E-CENTURY PUBLISHING CORP
关键词
Breast cancer; triple negative breast cancer; ETS1; YAP; prognosis; metastasis
类别
资金
- National Natural Science Foundation of China [81871888, 82002581, 82172942]
- China Postdoctoral Science Foundation [2020M671375]
- Jiangsu Province Postdoctoral Research Funding Scheme [2020Z261]
ETS1 is highly expressed in breast tumor tissues, specifically associated with tumor metastasis and poor survival in TNBC. Depletion of ETS1 inhibited cell proliferation and migration in TNBC cells by downregulating YAP and its target genes.
E26 transcription factor-1 (ETS1) is involved in extracellular matrix remodeling, migratory infiltration and angiogenesis in tumors and known to play an important role in tumor progression. However, the mechanism by which ETS1 promotes tumor progression remains elusive. In this report, we show that ETS1 is highly expressed in breast tumor tissues and specifically associated with the tumor metastasis and poor survival in triple negative breast cancer (TNBC) tumors, upon analysis by immunohistochemical (IHC) staining of tumor samples from 240 breast cancer cases. Depletion of ETS1 in TNBC cells by shETS1 significantly inhibited the cell proliferation and migration. Mechanistically, knockdown of ETS1 in TNBC cells dramatically reduced expression of YAP and the YAP target genes, and overexpression of YAP in the ETS1 knockdown cells restored the cell proliferation and migration. These data indicate that YAP is a downstream effector mediating the ETS1-promoted TNBC cell proliferation and migration. Taken together, our results suggest that ETS1 promotes TNBC progression through the YAP signaling.
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