An Update on Treatment Options for Methicillin- Resistant Staphylococcus aureus (MRSA) Bacteremia: A Systematic Review

Since the last century, methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has become a major global and public health concern not only in terms of morbidity and mortality but also the duration of hospital stay, healthcare cost, and antimicrobial choices. Especially alarming is the growing antimicrobial resistance due to their misuse and overuse, which has led the world to be exhausted of its effective antibiotic resources. In this review article, we sought to figure out the most efficacious antimicrobial agents to treat MRSA-related bloodstream infections. We compared the data from reviewing reports from 2017 to 2022 and summarized their comparative efficacy and cost-effectiveness. Although we focused on vancomycin and daptomycin, which are the current Infectious Disease Society Of America (IDSA)-recommended antibiotics for MRSA bacteremia treatment, a deep dive into the newer agents revealed better efficacy and treatment outcome in the combination of ceftaroline (13-lactam) with daptomycin compared to traditional standard monotherapy (vancomycin/daptomycin monotherapy). Also, the IDSA recommended high-dose daptomycin (8-10 mg/kg) therapy for MRSA bacteremia treatment to be more effective in cases with vancomycin-reduced susceptibility. Moreover, we did not find any trial or study describing the use of ceftaroline as a monotherapy to compare its efficacy in MRSA bacteremia with the current standard therapy. The upshot is that we need more large-scale clinical trials exploring in-depth effectiveness and adverse effects to decide on newer agents like 13-lactams to use as routine therapy for MRSA bacteremia.

Automated summary

Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has become a major global health concern due to its increasing antimicrobial resistance. This review article compared the efficacy of different antimicrobial agents for treating MRSA-related bloodstream infections and found that the combination of ceftaroline and daptomycin showed better efficacy compared to standard monotherapy with vancomycin or daptomycin. High-dose daptomycin therapy was also found to be more effective in cases with reduced susceptibility to vancomycin. However, more large-scale clinical trials are needed to explore the effectiveness and adverse effects of newer agents like 13-lactams for routine therapy in MRSA bacteremia.