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Mechanisms of microRNA action in rectal cancer radiotherapy

期刊

CHINESE MEDICAL JOURNAL
卷 135, 期 17, 页码 2017-2025

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CM9.0000000000002139

关键词

MicroRNAs; Rectal cancer; Radiotherapy; Mechanisms

资金

  1. Basic Research for Application of Sichuan Province, China [2020YJ0066]
  2. Key Research and Development Projects of Sichuan Province, China [2020YFS0430]
  3. Key Research and Development Projects of Sichuan Province, China [2018SZ0136]

向作者/读者索取更多资源

miRNAs play important roles in signaling pathways related to apoptosis, autophagy, the cell cycle, DNA damage repair, proliferation, and metastasis during radiotherapy in patients with rectal cancer, and may serve as potential radiotherapeutic biomarkers for rectal cancer.
Preoperative neoadjuvant chemoradiotherapy, combined with total mesorectal excision, has become the standard treatment for advanced localized rectal cancer (RC). However, the biological complexity and heterogeneity of tumors may contribute to cancer recurrence and metastasis in patients with radiotherapy-resistant RC. The identification of factors leading to radioresistance and markers of radiosensitivity is critical to identify responsive patients and improve radiotherapy outcomes. MicroRNAs (miRNAs) are small, endogenous, and noncoding RNAs that affect various cellular and molecular targets. miRNAs have been shown to play important roles in multiple biological processes associated with RC. In this review, we summarized the signaling pathways of miRNAs, including apoptosis, autophagy, the cell cycle, DNA damage repair, proliferation, and metastasis during radiotherapy in patients with RC. Also, we evaluated the potential role of miRNAs as radiotherapeutic biomarkers for RC.

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