期刊
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
卷 122, 期 2, 页码 75-87出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/13813455.2016.1148053
关键词
High-fat/high-sucrose diet; inflammation; insulin sensitivity; pomegranate flower; pomegranate seed oil
资金
- Buckingham Institute for Translational Medicine (BITM) at the University of Buckingham, United Kingdom
- MOBIDOC device launched under the Supported Project to the research and Innovation System (PASRI) - European Union
- Ministry of Higher Education and Scientific Research (Tunisia)
- Sanofi Winthrop-Tunisia Pharmaceutical
Objective: The potentially beneficial effects of pomegranate peel (PPE), flower (PFE) and seed oil (PSO) extracts, in comparison with rosiglitazone, on adiposity, lipid profile, glucose homoeostasis, as well as on the underlying inflammatory mechanisms, were examined in high-fat and high-sucrose (HF/HS) diet-induced obese (DIO) mice. Measurements: Body weight, body fat, energy expenditure, food and liquid intake, blood glucose, and plasma levels of insulin, lipids and cytokines were measured. Results: After two weeks, PSO (2ml/kg/day) and rosiglitazone (3mg/kg/day) had not improved glucose intolerance. After 4 weeks, both treatments significantly reduced fasting blood glucose and an insulin tolerance test showed that they also improved insulin sensitivity. Treatment with PPE, PFE and PSO, reduced the plasma levels of the pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumour necrosis factor- (TNF-), and PFE increased the level of the anti-inflammatory cytokine interleukin-10 (IL-10). Conclusion: PPE, PFE and PSO have anti-inflammatory properties. PSO also improved insulin sensitivity.
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