期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/ijms232416165
关键词
skin; zinc; zinc transporters; AE; SCD-EDS; skin disorders
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [2019005607]
- Ajou University Research Fund
- Korea Initiative for fostering University of Research and Innovation Program of the National Research Foundation (NRF) - Korean government (MSIT) [NRF2021M3H1A104892211]
This article discusses the importance of zinc in maintaining healthy skin and the role of zinc transporters in regulating zinc homeostasis. Zinc deficiency can lead to various skin disorders, but the use of zinc-containing compounds can effectively treat and protect the skin.
Zinc is an important trace mineral in the human body and a daily intake of zinc is required to maintain a healthy status. Over the past decades, zinc has been used in formulating topical and systemic therapies for various skin disorders owing to its wound healing and antimicrobial properties. Zinc transporters play a major role in maintaining the integrity of the integumentary system by controlling zinc homeostasis within dermal layers. Mutations and abnormal function of zinc-transporting proteins can lead to disease development, such as spondylocheirodysplastic Ehlers-Danlos syndrome (SCD-EDS) and acrodermatitis enteropathica (AE) which can be fatal if left untreated. This review discusses the layers of the skin, the importance of zinc and zinc transporters in each layer, and the various skin disorders caused by zinc deficiency, in addition to zinc-containing compounds used for treating different skin disorders and skin protection.
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