期刊
NEW MICROBIOLOGICA
卷 45, 期 4, 页码 296-303出版社
EDIZIONI INT SRL
关键词
Hepatitis B virus; Hepatitis C virus; Systemic lupus erythematosus; Cutaneous Lupus; Serological; epidemiological evaluation
类别
资金
- Gilead Sciences Srl
This study aimed to estimate the prevalence of HCV and HBV infections in a cohort of SLE and CLE patients, and investigate their possible associations with disease clinical/laboratory features and disease activity status. The prevalence of chronic HBV infection was 2.2% in CLE patients, while no HBsAg positive patients were identified in SLE patients. On the other hand, the prevalence of anti-HCV positive was 2.2% in SLE patients, while no anti-HCV positive patients were identified in CLE patients. Hemodialysis was significantly associated with anti-HBc positivity in SLE patients. These findings suggest a possible protective role of SLE in HBV infection, and a potential involvement of HCV in some SLE-related clinical and immunological features.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a multifactorial etiology. The primary aim of this study was to estimate HCV and HBV infection prevalence in a cohort of SLE and Cutaneous Lupus Erythematosus (CLE). We assessed the frequency of these infections in our cohort and the possible associations with disease clinical/laboratory features and disease activity status. The prevalence of chronic HBV infection was 2.2% in the CLE group, while no HBsAg positive patients were identified in the SLE group. Conversely, the prevalence of anti-HCV positive was 2.2% in the SLE group while no anti-HCV positive patients were identified in the CLE group. We found no significant association between anti-HBc positive status and clinical manifestations or disease activity status in either group of patients. Hemodialysis resulted significantly associated with anti-HBc positivity in SLE. In the present study, we found HBsAg positivity in CLE patients but not in the Systemic form (SLE); conversely, a similar prevalence of anti-HBc antibodies in both groups was observed. A possible protective role exerted by SLE in HBV infection may be hypothesized. A higher frequency of HCV infection in SLE compared to CLE suggests a possible involvement of HCV in some SLE-related clinical and immunological features.
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