Breast Amyloidosis: A Case Report and Literature Review br

Amyloidosis is an uncommon disorder characterized by extracellular accumulation of misfolded proteins in tissues. We report a unique case of localized breast amyloidosis in an asymptomatic 56-year-old woman with systemic lupus erythematosus, presented as suspicious microcalcifications without mass on mammography. Vacuum biopsy confirmed amyloidosis, producing the typical apple-green birefringence under polarized light after staining with Congo-red. Further workup and follow-up to exclude development into systemic amyloidosis or hematologic malignancy is recommended. If negative, the prognosis is very good, thus no further treatment is needed. A brief review of the literature revealed more about the typical findings and recommended management

Automated summary

Amyloidosis is a rare disorder characterized by the accumulation of misfolded proteins outside cells in tissues. This unique case study reports on a 56-year-old woman with systemic lupus erythematosus who had localized breast amyloidosis presenting as suspicious microcalcifications but no mass on mammography. Biopsy confirmed the diagnosis, and follow-up is recommended to exclude systemic amyloidosis or hematologic malignancy.