期刊
CHEMISTRY-SWITZERLAND
卷 4, 期 4, 页码 1208-1225出版社
MDPI
DOI: 10.3390/chemistry4040081
关键词
Annonaceae; essential oils; Bocageopsis; Onychopetalum; lipase; cancer
资金
- Fundacao de Amparo a Pesquisa do Estado do Amazonas (FAPEAM) [FAPEAM-006/2019]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [305942/2020-4]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES) [001]
This study aims to explore the chemical constituents and biological activities of essential oils from Amazonian plants. By conducting various experiments, certain compounds were identified to have potential cytotoxic and anti-lipase activities.
Essential oils from Amazonian species are gaining increasing interest worldwide due to their medicinal and cosmetic applications; however, the relation among the chemical constituents and their biological properties are not well explored. Therefore, the present research aims to obtain an understanding of the bioactivity of chemical compounds in the essential oils of plants from the Annonaceae family (Bocageopsis pleiosperma, Onychopetalum amazonicum, Unonopsis duckei, U. floribunda, U. rufescens, U. stipitata, U. guatterioides, Duguetia flagellaris and Xylopia benthamii). By means of gas chromatography coupled to mass spectrometry, in vitro cytotoxic and anti-lipase assays, principal component analysis and molecular docking, it was possible to establish the main compounds that may be responsible for the cytotoxic effect of O. amazonicum and B. pleiosperma. Moreover, the anti-lipase potential of D. flagellaris was also established, as well as its composition related to the activity. Thus, by the employed strategy, allo-aromadendrene, cryptomerione, delta-cadinene and beta-bisabolene were suggested as plausible cytotoxic agents against cancer cell lines, and dehydroaromadendrene, spathulenol and elemol, against lipase. The present study provides significant information on the chemical profile and bioactivity studies of Amazon Annonaceae aromatic plants.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据