相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing
Yu-Xuan Lu et al.
ELIFE (2021)
Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila
Luke Stephen Tain et al.
ELIFE (2021)
Functional Aging in Male C57BL/6J Mice Across the Life-Span: A Systematic Behavioral Analysis of Motor, Emotional, and Memory Function to Define an Aging Phenotype
Shuichi Yanai et al.
FRONTIERS IN AGING NEUROSCIENCE (2021)
The Paneth Cell: The Curator and Defender of the Immature Small Intestine
Shiloh R. Lueschow et al.
FRONTIERS IN IMMUNOLOGY (2020)
Colonic epithelial cell diversity in health and inflammatory bowel disease
Kaushal Parikh et al.
NATURE (2019)
Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation
Ming Zhao et al.
EMBO MOLECULAR MEDICINE (2018)
TORC1 inhibition enhances immune function and reduces infections in the elderly
Joan B. Mannick et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Intestinal Snakeskin Limits Microbial Dysbiosis during Aging and Promotes Longevity
Anna M. Salazar et al.
ISCIENCE (2018)
Feedback regulation of steady-state epithelial turnover and organ size
Jackson Liang et al.
NATURE (2017)
Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine
Shai Bel et al.
SCIENCE (2017)
Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women
Beate Ott et al.
SCIENTIFIC REPORTS (2017)
ROBUST HYPERPARAMETER ESTIMATION PROTECTS AGAINST HYPERVARIABLE GENES AND IMPROVES POWER TO DETECT DIFFERENTIAL EXPRESSION
Belinda Phipson et al.
ANNALS OF APPLIED STATISTICS (2016)
Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice
Sebastian I. Arriola Apelo et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)
Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age
Hirotaka Shoji et al.
MOLECULAR BRAIN (2016)
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
Alessandro Bitto et al.
ELIFE (2016)
Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction
Jennifer C. Regan et al.
ELIFE (2016)
The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity
Cathy Slack et al.
CELL (2015)
How and why to study autophagy in Drosophila: It's more than just a garbage chute
Peter Nagy et al.
METHODS (2015)
Rapamycin preserves gut homeostasis during Drosophila aging
Xiaolan Fan et al.
ONCOTARGET (2015)
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
Dao-Fu Dai et al.
AGING CELL (2014)
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
Richard A. Miller et al.
AGING CELL (2014)
PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan
Linlin Guo et al.
CELL (2014)
mTOR inhibition improves immune function in the elderly
Joan B. Mannick et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner
Matthew Ulgherait et al.
CELL REPORTS (2014)
Late-life rapamycin treatment reverses age-related heart dysfunction
James M. Flynn et al.
AGING CELL (2013)
Paneth Cells: Maestros of the Small Intestinal Crypts
Hans C. Clevers et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 75 (2013)
Paneth cells as a site of origin for intestinal inflammation
Timon E. Adolph et al.
NATURE (2013)
TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
Stacey Robida-Stubbs et al.
CELL METABOLISM (2012)
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
Oemer H. Yilmaz et al.
NATURE (2012)
CHRONIC INHIBITION OF MAMMALIAN TARGET OF RAPAMYCIN BY RAPAMYCIN MODULATES COGNITIVE AND NON-COGNITIVE COMPONENTS OF BEHAVIOR THROUGHOUT LIFESPAN IN MICE
J. Halloran et al.
NEUROSCIENCE (2012)
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Dudley W. Lamming et al.
SCIENCE (2012)
Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
Vladimir N. Anisimov et al.
CELL CYCLE (2011)
EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila
Huaqi Jiang et al.
CELL STEM CELL (2011)
Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment
Juergen Cox et al.
JOURNAL OF PROTEOME RESEARCH (2011)
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Toshiro Sato et al.
NATURE (2011)
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Ivana Bjedov et al.
CELL METABOLISM (2010)
A Transient Niche Regulates the Specification of Drosophila Intestinal Stem Cells
Divya Mathur et al.
SCIENCE (2010)
Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila
Benoit Biteau et al.
PLOS GENETICS (2010)
Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity
Chunli Ren et al.
EXPERIMENTAL GERONTOLOGY (2009)
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison et al.
NATURE (2009)
mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
Chong Chen et al.
SCIENCE SIGNALING (2009)
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Patrice D. Cani et al.
DIABETES (2008)
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Ken Cadwell et al.
NATURE (2008)
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
Juergen Cox et al.
NATURE BIOTECHNOLOGY (2008)
Optimization of dietary restriction protocols in Drosophila
Timothy M. Bass et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2007)
Improved scoring of functional groups from gene expression data by decorrelating GO graph structure
Adrian Alexa et al.
BIOINFORMATICS (2006)
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara et al.
NATURE (2006)
Role and regulation of starvation-induced autophagy in the Drosophila fat body
RC Scott et al.
DEVELOPMENTAL CELL (2004)
Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
JD Soderholm et al.
GUT (2002)
Histone H3 phosphorylation and cell division
F Hans et al.
ONCOGENE (2001)