3.9 Review

Potential benefit of lymph node dissection during radical nephrectomy for kidney cancer: A review and critical analysis of current literature

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Summary: Several studies have explored the potential of specific miRNAs in predicting RCC recurrence, showing varying levels of accuracy and significant associations with survival outcomes. However, further research is needed to determine the efficacy of miRNA-based prognostic markers for routine clinical use.

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Summary: This study found that patterns of metastasis vary between histologic subtypes of metastatic RCC and are associated with overall survival. The data highlight the clinical and biological variability between histologic subtypes and suggest that patterns of metastasis may reflect differences in underlying disease biology. Further research is encouraged to investigate differences in immune, molecular, and genetic profiles between metastatic sites and histologic subtypes.

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MicroRNAs in Body Fluids: A More Promising Biomarker for Clear Cell Renal Cell Carcinoma

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Summary: This review summarizes the current state of using biomarkers to predict RCC recurrence after curative treatment, highlighting the accuracy and clinical implications of various biomarkers in prediction models. Future prognostic models may combine classical features with novel biomarkers for more accurate treatment and follow-up planning.

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Summary: Renal cell carcinoma (RCC) is a deadly urinary malignancy with current diagnostic techniques being harmful and unspecific for low-grade tumors. This study aimed to identify a stable normalizer for urine RCC miRNA studies and establish diagnostic and follow-up miRNA profiles. Using miR-20a-5p as normalizer, a diagnostic model for RCC with three miRNAs was adjusted and validated. The identified miRNA profiles may potentially improve non-invasive diagnosis and follow-up of RCC, pending confirmation in larger cohorts.

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Management of local recurrence after radical nephrectomy: surgical removal with or without systemic treatment is still the gold standard. Results from a multicenter international cohort

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Summary: The study evaluated the survival outcomes of patients with local recurrence after radical nephrectomy and found that surgical treatment in combination with systemic therapy can improve cancer-specific survival rates. Complication rates following surgical treatment of local recurrence were relatively low.

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Nerve-sparing Robot-assisted Retroperitoneal Lymph Node Dissection: The Monoblock Technique

Luca Afferi et al.

Summary: This study describes the surgical steps and perioperative outcomes of robotic nerve-sparing unilateral template RPLND with en-bloc resection in patients with suspected retroperitoneal metastatic testicular cancer. The procedure is safe and feasible, allowing removal of a high number of lymph nodes with good functional outcomes and excellent short-term survival outcomes without recurrences.

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Nam-Son Vuong et al.

Summary: This study assessed the feasibility of robot-assisted radical nephrectomy with inferior vena cava thrombectomy and found that robotic procedures had advantages in terms of blood loss and length of stay, with longer operative time. This technique is feasible and safe for experienced surgical teams, with no difference in complications rate and oncological outcomes compared to standard open procedures.

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Comparison between minimally-invasive partial and radical nephrectomy for the treatment of clinical T2 renal masses: results of a 10-year study in a tertiary care center

Daniele Amparore et al.

Summary: The study indicates that in experienced hands, minimally-invasive partial nephrectomy is feasible for cT2 renal tumors, providing perioperative and oncological safety profiles comparable to radical nephrectomy, with advantages in terms of functional outcomes.

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Umberto Carbonara et al.

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Enrico Checcucci et al.

Summary: The study found that surgeons have a positive perception towards holograms and mixed reality (MR) as a tool for preoperative planning before partial nephrectomy, believing it can enhance surgical planning precision and understanding of surgical complexity. Additionally, after experiencing MR firsthand, a significant percentage of surgeons changed their clamping and resection approach, opting for a more selective method compared to traditional CT image visualization.

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Sentinel Lymph Node Biopsy in Renal Tumors: Surgical Technique and Safety

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BRITISH JOURNAL OF CANCER (2016)

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EAU Guidelines on Renal Cell Carcinoma: 2014 Update

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Riaz J. Karmali et al.

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The Need for Lymph Node Dissection in Nonmetastatic Breast Cancer

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ANNUAL REVIEW OF MEDICINE, VOL 64 (2013)

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Lymphadenectomy Improves Survival of Patients With Renal Cell Carcinoma and Nodal Metastases

Jared M. Whitson et al.

JOURNAL OF UROLOGY (2011)

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The number of lymph nodes examined and staging accuracy in renal cell carcinoma

C Terrone et al.

BJU INTERNATIONAL (2003)