Spontaneous regression in a primary adenocarcinoma of lung with epidermal growth factor receptor mutation

Spontaneous regression (SR) has been reported sporadically in few tumor types. Its occurrence in non-small-cell lung cancer is relatively rare, more so with adenocarcinoma histology. Various mechanisms of SR have been postulated in literature that may play a role in triggering immune response. However, the exact underlying mechanism has yet to be ascertained. We report a rare case of true SR in a primary adenocarcinoma of lung with tumor-infiltrating lymphocytes and epidermal growth factor receptor mutation.

Automated summary

Spontaneous regression (SR) is relatively rare in non-small-cell lung cancer, especially with adenocarcinoma histology. Various mechanisms have been postulated, but the exact underlying mechanism is still uncertain.