期刊
ALLERGOLOGY INTERNATIONAL
卷 65, 期 -, 页码 S38-S44出版社
JAPANESE SOCIETY ALLERGOLOGY
DOI: 10.1016/j.alit.2016.05.015
关键词
Bronchial asthma; Epinastine; Histamine receptors; Psychological stress; Thioperamide
资金
- Ministry of Education, Culture, Sports, Science, and Technology [S1511001L]
- [25461164]
- Grants-in-Aid for Scientific Research [25461164, 16K09552] Funding Source: KAKEN
Background: Psychological stress is one of the major risk factors for asthma exacerbation. Although histamine in the brain acts as an excitatory and inhibitory neurotransmitter associated with psychological stress, the contribution of brain histamine to psychological stress-induced exacerbation of asthma remains unclear. The objective of this study was to investigate the role of histamine receptors in the CNS on stress induced asthma aggravation. Methods: We monitored the numbers of inflammatory cells and interleukin (IL)-13 levels in bronchoalveolar lavage fluid, airway responsiveness to inhaled methacholine, mucus secretion in airway epithelial cells, and antigen-specific IgE contents in sera in a murine model of stress-induced asthma treated with epinastine (an H1R antagonist), thioperamide (an H3/4R antagonist), or solvent. Results: All indicators of stress-induced asthma exacerbation were significantly reduced in stressed mice treated with epinastine compared with those treated with solvent, whereas treatment with thioperamide did not reduce the numbers of inflammatory cells in the stressed mice. Conclusions: These results suggest that H1R, but not H3/4R, may be involved in stress-induced asthma exacerbations in the central nervous system. Copyright (c) 2016, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
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