期刊
MICROBIOLOGY AUSTRALIA
卷 43, 期 4, 页码 173-176出版社
CSIRO PUBLISHING
DOI: 10.1071/MA22057
关键词
alternative treament options; Australian situation; Candida auris; clinical issues; emerging fungal pathogens; environmental sources; laboratory identification; multidrug resistance
类别
资金
- National Health and Medical Research Council of Australia (NHMRC) [APP1121936]
Candida auris is currently the most talked about multidrug-resistant emerging fungal pathogen, posing serious challenges to public health authorities due to its highly contagious nature and difficult-to-control nosocomial outbreaks worldwide. It shows high levels of multidrug-resistance and extreme tolerance to conditions that usually limit fungal transmission. Recently, it has been found in India associated with coastal aquatic environments.
Currently Candida auris is the most talked about multidrug-resistant emerging fungal pathogen. It can cause difficult-to-control nosocomial outbreaks worldwide, being highly contagious, and poses serious challenges to public health authorities. A wide spectrum of infections, ranging from superficial mucosal infections, candidemia to disseminated deep-seated disease, having been reported from more than 40 countries, including Australia. Outbreaks are associated with high mortality rates due to rapid transmission and challenges in prevention, control, and treatment. It is shows a high multidrug-resistance (with 90% of isolates resistant to fluconazole), and is extremely tolerant to conditions which usually limit fungal transmission, including commonly used disinfectants. Whole genome analysis has revealed five different closely related clades (named after the geographical areas they have been first encoundered) with distinct clonal lineages. Its environmental niche remained a mystery until recently when it was found in India in association with costal aquatic environments.
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