期刊
AGING-US
卷 14, 期 24, 页码 9942-9950出版社
IMPACT JOURNALS LLC
关键词
Qi Ling decoction; prostate cancer; castration-resistance; tumor
资金
- General Program of National Natural Science Foundation of China [82174199]
- Shanghai University of Traditional Chinese Medicine Industry Development Center Medical and Nursing Integrated Science and Technology Innovation Project [2069]
- Shanghai Municipal Health Commission Special Subject of Chinese Traditional Medicine Research [2020JQ002]
- Shanghai Science and Technology Commission Shanghai Natural Science Foundation Project [19ZR1458200]
- The Third Batch of Young Chinese name training program of LongHua Hospital Shanghai University of Traditional Chinese Medicine [RC-2017-01-14]
Abiraterone acetate has shown impressive results in improving progression-free survival in patients with metastatic castration-resistant prostate cancer. However, some patients may develop resistance to abiraterone. This study investigates the potential of a traditional Chinese medicine called Qi Ling decoction (QLD) in attenuating abiraterone resistance in prostate cancer. The results demonstrate that QLD can promote abiraterone-induced apoptosis and cell death, and restore the sensitivity of prostate cancer cells to abiraterone. These findings suggest that QLD may serve as a potential remedy to enhance the effectiveness of abiraterone therapy for patients with castration-resistant prostate cancer.
Abiraterone acetate has exhibited impressive results in improving progression-free survival of patients with metastatic castration-resistant prostate cancer. However, many patients may develop abiraterone resistance with a variable duration of response. Hence, identifying a remedy to overcome abiraterone resistance is critical for patients with castration-resistant prostate cancer. In this study, we aim to explore the potential of Qi Ling decoction (QLD), a traditional Chinese medicine, in attenuating abiraterone resistance in prostate cancer. Cell viability and apoptosis were respectively measured by Cell Counting Kit-8 (CCK-8) assay and flow cytometry. The protein levels were assessed by Western blotting assay. Autophagosome formation was quantified by counting LC3 puncta. We found that QLD was capable of promoting abiraterone-induced apoptosis and cell death of PC3-AbiR and DU145-AbiR cells in vitro. A combination of QLD and abiraterone yielded a better tumor inhibition effect than QLD alone and abiraterone alone. Further investigation revealed that QLD restored the abiraterone sensitivity of PC3-AbiR and DU145-AbiR cells through modulating autophagy. These findings suggest that QLD might serve as a potential remedy to enhance the therapeutical effect of abiraterone for patients with castration-resistant prostate cancer.
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