Robust cell identity specifications through transitions in the collective state of growing developmental systems

Mammalian development is characterized with transitions from homogeneous populations of precursor to heterogeneous population of specified cells. We review here the main dynamical mechanisms through which such transitions are conceptualized, and discuss that the differentiation timing, robust cell-type proportions and recovery upon perturbation are emergent property of proliferating and communicating cell populations. We argue that studying developmental systems using transitions in collective system states is necessary to describe observed experimental features, and propose additionally the basis of a novel analytical method to deduce the relationship between single-cell dynamics and the collective, symmetry-broken states in cellular populations.

Automated summary

This paper reviews the dynamical mechanisms of mammalian development and discusses the emergent properties of cell populations in terms of differentiation timing, cell-type proportions, and recovery from perturbations. It argues that studying developmental systems through transitions in collective system states is necessary to describe experimental features, and proposes a novel analytical method to deduce the relationship between single-cell dynamics and collective, symmetry-broken states in cellular populations.