Retrospective analysis of clinical characteristics and related influencing factors of Kawasaki disease

Article Immunology

Single center blind testing of a US multi-center validated diagnostic algorithm for Kawasaki disease in Taiwan

Ho-Chang Kuo et al.

Summary: This study validates the applicability of our algorithm in Taiwan, showing high sensitivity and positive predictive value.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

The role of mitochondria in the pathogenesis of Kawasaki disease

Mikayla A. Beckley et al.

Summary: Kawasaki disease is a systemic vasculitis that affects children, particularly the coronary arteries. This study proposes that mitochondria, which serve as a central hub for energy generation and cellular processes, may play a critical role in the amplified inflammatory response seen in Kawasaki disease. Mitochondrial dysfunction alters immune cell activity and may contribute to the pathogenesis of the disease. Additionally, population-specific variants in mitochondrial DNA may explain racial disparities in disease risk and treatment response.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Increased Pentraxin 3 Levels Correlate With IVIG Responsiveness and Coronary Artery Aneurysm Formation in Kawasaki Disease

Toshiyuki Kitoh et al.

Summary: PTX3 is a reliable biomarker for predicting IVIG resistance and subsequent CAL formation in patients with KD, with a specificity of 88.5% and a sensitivity of 94.4%.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Non-Typhoidal Salmonella and the Risk of Kawasaki Disease: A Nationwide Population-Based Cohort Study

Thomas Yen-Ting Chen et al.

Summary: This study found an association between NTS infection and an increased risk of KD in Taiwanese children, especially in children aged 2 years and younger, female patients, and those without allergic diseases.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Immune response to intravenous immunoglobulin in patients with Kawasaki disease and MIS-C

Yanfang P. Zhu et al.

Summary: The study shows that IVIG can target activated neutrophils expressing IL-1 beta, reducing the circulating activated cells and alleviating inflammation in patients with MIS-C and KD.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Article Rheumatology

High risk of coronary artery aneurysm in Kawasaki disease

Maria Mossberg et al.

Summary: This study found a significantly high risk of CAA development in young children diagnosed with iKD, highlighting the importance of rapid intense treatment and vigilance in infants to reduce the frequency of CAA.

RHEUMATOLOGY (2021)

添加到收藏夹

Review Plant Sciences