Enantioselective Nickel-Catalyzed C(sp3)-H Activation of Formamides

Enantioselective Ni-catalyzed C(sp(3))-H bond activation remains an elusive challenge. Herein, we used phosphine oxide-ligated Ni-Al bimetallic catalyst to realize enantioselective Ni-catalyzed aliphatic C(sp(3))-H activation of formamides, providing a series of chiral N-containing heterocycles in 40-95 % yield and 70-95 % ee.

Automated summary

Enantioselective Ni-catalyzed C(sp(3))-H bond activation was achieved using a phosphine oxide-ligated Ni-Al bimetallic catalyst, leading to the synthesis of a series of chiral N-containing heterocycles in good yields and high enantioselectivity.