期刊
TRANSLATIONAL PSYCHIATRY
卷 6, 期 -, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/tp.2016.36
关键词
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类别
资金
- European Research Council (Beyond the Genetics of Addiction) [ERC-284167]
- Foundation Volksbond Rotterdam
- Netherlands Organization for Health Research and Development (ZonMW) [31160212]
- NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation
- US National Institutes of Health, National Institute on Drug Abuse [R00DA023549]
- NIDA [R37 DA-018673]
- NSF [BCS-1229450]
- NIH [U01 MH094432]
- Netherlands Organization for Scientific Research (NWO) [480-05-003]
- Dutch Brain Foundation
- VU University Amsterdam
- UK Medical Research Council
- Wellcome Trust [102215/2/13/2, WT083431MA]
- University of Bristol
- 23andMe
- Oak Foundation
- UK Medical Research Council [MC_UU_12013/6]
- British Heart Foundation
- Cancer Research UK
- Economic and Social Research Council
- Medical Research Council and the National Institute for Health Research
- UK Clinical Research
- United States National Institute on Drug Abuse [R00DA023549]
- Australian Research Council [DP0343921, DP0664638, DP1093900, A7960034, A79906588, A79801419, DP0770096, DP0212016]
- Australian National Health and Medical Research Council Australia Fellowships [464914, 619667]
- ARC future fellowship [FT110100548]
- National Institute on Drug Abuse [P60 DA011015, R01 DA012845, R01 DA021913, R01 DA021905, R01 DA035804, DA05147, DA13240, DA024417]
- FP7 [278913, 306031, 313010]
- Center of Excellence in Genomics (EXCEGEN)
- University of Tartu (SP1GVARENG)
- Academy of Finland Center of Excellence in Complex Disease Genetics [213506, 129680]
- Academy of Finland [100499, 205585, 118555, 141054, 265240, 263278, 264146]
- National Institute of Alcohol Abuse and Alcoholism [AA-12502, AA-00145, AA-09203, AA15416, K02AA018755]
- Sigrid Juselius Foundation
- Welcome Trust Sanger Institute, UK
- 'Instituto de Salud Carlos III-FIS' [PI11/00571, PI11/01629, PI12/01139]
- 'Plan Nacional Sobre Drogas' (PNSD) [20110080]
- 'Agencia de Gestio d'Ajuts Universitaris i de Recerca-AGAUR, Generalitat de Catalunya' [2014SGR1357]
- 'Departament de Salut', Government of Catalonia, Spain
- 'Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion', Spain
- National Institute on Alcohol Abuse and Alcoholism [AA09367, AA11886]
- National Institute on Mental Health [MH066140]
- Netherlands Organization for Scientific Research [ZonMW Addiction 31160008, ZonMW 940-37-024, NWO/SPI 56-464-14192, NWO-400-05-717, NWO-MW 904-61-19, NWO-MagW 480-04-004, NWO-Veni 016-115-035]
- European Research Council [ERC-284167, ERC-230374]
- Centre for Medical Systems Biology (NWO Genomics)
- Netherlands Bioinformatics [Center/BioAssist/RK/2008.024]
- EMGO+ Institute for Health and Care Research
- Neuroscience Campus Amsterdam, BBMRI-NL (Biobanking and Biomolecular Resources Research Infrastructure) [184.021.007]
- Avera Institute, Sioux Falls, South Dakota (USA)
- National Institutes of Health [4R37DA018673-06, RC2 MH089951, NIH R01 HD042157-01A1, MH081802, 1RC2 MH089951, 1RC2 MH089995]
- Rutgers University Cell and DNA Repository cooperative agreement (National Institute of Mental Health) [U24 MH068457-06]
- Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health
- Netherlands Scientific Organization (NWO) [480-05-003]
- Department of Psychology and Education of the VU University Amsterdam
- National Institutes of Health Grants [AA07535, AA0758O, AA07728, AA10249, AA13320, AA13321, AA14041, AA11998, AA17688, DA012854, DA018267, DA018660, DA23668, DA019951]
- Australian National Health and Medical Research Council [241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498, 628911]
- 5th Framework Programme (FP-5) GenomEUtwin Project [QLG2-CT-2002-01254]
- Centre for Research Excellence on Suicide Prevention (CRESP-Australia)
- Netherlands Organisation for Scientific Research (Brain and Cognition) [056-21-010]
- Netherlands Organisation for Scientific Research (GB-MAGW) [480-03-005]
- Stichting Achmea Slachtoffer en Samenleving (SASS)
- Netherlands Organisation for Scientific Research
- Utrecht University
- Netherlands Organization for Health Research and Development
- ZonMW [31160212]
- Canadian Institutes of Health Research
- Heart and Stroke Foundation of Canada
- Netherlands Organization for Scientific Research NWO (Medical Research Council program) [GB-MW 940-38-011]
- Netherlands Organization for Scientific Research NWO (ZonMW Brainpower) [100-001-004]
- Netherlands Organization for Scientific Research NWO (ZonMw Risk Behavior and Dependence) [60-60600-97-118]
- Netherlands Organization for Scientific Research NWO (ZonMw Culture and Health) [261-98-710]
- Netherlands Organization for Scientific Research NWO (Social Sciences Council medium-sized investment) [GBMaGW 480-01-006, GB-MaGW 480-07-001]
- Netherlands Organization for Scientific Research NWO (Social Sciences Council) [GB-MaGW 452-04-314, GB-MaGW 452-06-004]
- Netherlands Organization for Scientific Research NWO (NWO large-sized investment) [175.010.2003.005]
- Netherlands Organization for Scientific Research NWO (NWO Longitudinal Survey and Panel Funding) [481-08-013]
- Dutch Ministry of Justice (WODC)
- European Science Foundation (EuroSTRESS) [FP-006]
- Biobanking and Biomolecular Resources Research Infrastructure BBMRI-NL [CP 32]
- Accare Center for Child and Adolescent Psychiatry
- Wellcome Trust
- European Community's Seventh Framework Programme (FP7)
- National Institute for Health Research (NIHR)
- Clinical Research Facility and Biomedical Research Centre based at Guy's
- St Thomas' NHS Foundation Trust
- King's College London
- NWO (Netherlands Organization for Scientific Research) [91207039]
- National Institutes of Health to The Johns Hopkins University [N01-HG-65403]
- National Institutes of Health grant [RC2 DA028909, R01 DA12690, R01 DA12849, R01 DA18432, R01 AA11330, R01 AA017535]
- VA Connecticut
- Philadelphia VA MIRECCs
- MRC [MR/L022206/1, MC_UU_12013/1, MR/K023233/1, MC_UU_12013/6, G0802736] Funding Source: UKRI
- Medical Research Council [G0802736, MR/K023233/1, MR/L022206/1, MC_UU_12013/6, MR/K023195/1, MC_UU_12013/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0515-10023] Funding Source: researchfish
- Australian Research Council [FT110100548] Funding Source: Australian Research Council
Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N = 32 330) and four replication samples (N = 5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use.
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