期刊
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
卷 15, 期 -, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/17562848221115317
关键词
cholangiocarcinoma; FGFR; FGFR inhibitor; fusion; pemigatinib
Biliary tract cancers, a diverse and aggressive malignancy, have a poor prognosis and limited treatment options. However, advancements in genetic sequencing have opened up new avenues for targeted therapy in this field.
Biliary tract cancers are a diverse and aggressive malignancy that carry a poor chance for curative treatment and significant associated mortality. Current first-line treatment only extends median overall survival to roughly 1 year and is associated with a significant adverse event profile. Recently, advancements in genetic sequencing have opened new avenues of targeted treatment. In cholangiocarcinoma, FGFR2 alterations have been shown to be present in roughly 10-15% of intrahepatic cholangiocarcinoma. Pemigatinib, a FGFR1-4 inhibitor, has been shown to significantly extend survival in the second-line setting to over 20 months in patients who harbor FGFR2 fusions. Here, we outline the development and future direction of pemigatinib and other FGFR2 inhibitors in the field of advanced biliary tract cancers.
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