期刊
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
卷 20, 期 -, 页码 6443-6457出版社
ELSEVIER
DOI: 10.1016/j.csbj.2022.11.036
关键词
miR-142 in AML; miR-96 in hearing loss; miR-184 in keratoconus; miR-204 in retinal dystrophy; miR-15; miR-16 in CLL; miR140 in skeletal dysplasia
资金
- National Science Centre Poland
- [2016/22/A/NZ2/00184]
- [2020/39/B/NZ5/01970]
- [2020/39/D/NZ2/03106]
MicroRNAs (miRNAs) are small non-coding RNAs that posttranscriptionally regulate gene expression. Genetic variations in miRNA genes may affect their functioning and the development of human diseases.
MicroRNAs (miRNAs) are small non-coding RNAs that posttranscriptionally regulate the expression of most genes. They are involved in regulating many physiological processes, and aberrations in the levels of different miRNAs play an important role in the development of many diseases, including autoimmune diseases, neuropsychiatric diseases, and cancers. Although miRNAs are being intensively studied and levels of many miRNAs are either specifically increased or decreased in particular diseases, very little is known about the genetic variations of miRNA genes and their impact on the functioning of miRNA genes and human diseases. To shed more light on the potential effects of genetic variants in miRNA genes, we review here representative examples of SNPs, mutations linked to Mendelian diseases, and cancer somatic mutations located in miRNA genes and discuss their potential effects on the expression of miRNA genes, i.e., the structure and processing of miRNA precursors, the levels of generated miRNAs, miRNA target recognition/silencing, and impact on human diseases.CO 2022 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://creative-commons.org/licenses/by-nc-nd/4.0/).
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