期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 77, 期 12, 页码 2367-2372出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glab315
关键词
Frailty; Glycolysis; Metabolome; Serum; TCA cycle
资金
- Johns Hopkins University Claude D. Pepper Older Americans Independence Center - National Institute on Aging of the National Institutes of Health (NIH) [P30AG021334]
- NIH [UH3 AG056933, R01AG046441, K23 AG035005, 1S10OD025226-01]
- Bright Focus Foundation Research Award
- Nathan W. and Margaret T. Shock Aging Research Foundation
- American Federation for Aging Research [1S10OD025226-01]
- Nathan Shock Scholar in Aging
This study found that dysregulation of energy producing metabolic pathways is associated with frailty in older adults. Elevated levels of TCA cycle and glycolytic intermediates were observed in frail subjects, while the differences in ATP and other energy metabolites between young, nonfrail, and frail adults were not significant. Additionally, serum levels of neurotransmitters were significantly elevated in older adults with frailty.
Dysregulation of energy producing metabolic pathways has been observed in older adults with frailty. In this study, we used liquid chromatography-mass spectrometry technology to identify aging- and frailty-related differences in metabolites involved in glycolysis, the tricarboxylic (TCA) cycle, and other energy metabolism-related pathways in the serum of a cohort of community-dwelling adults aged 20-97 (n = 146). We also examined the relationship between serum levels of metabolites and functional measures, physical frailty, and risk status for adverse health outcomes. We observed elevated levels of TCA cycle and glycolytic intermediates in frail subjects; however, the differences in the levels of ATP and other energy metabolites between young, nonfrail, and frail adults were not significant. Instead, we found that serum levels of neurotransmitters N-acetyl-aspartyl-glutamate, glutamate, and gamma-aminobutyric acid were significantly elevated in older adults with frailty. These elevations of glycolytic and TCA cycle intermediates, and neurotransmitters may be part of the biological signature of frailty.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据