期刊
2022 30TH EUROPEAN SIGNAL PROCESSING CONFERENCE (EUSIPCO 2022)
卷 -, 期 -, 页码 922-926出版社
IEEE
关键词
Brain connectomics; graph representation learning; Siamese network; graph convolutional network
类别
资金
- NSF [CCF-1750428, CCF-1934962, ECCS-1809356]
Advances in graph signal processing contribute to the integration of brain structure and function in network neuroscience. This study proposes a supervised graph representation learning framework to model the relationship between brain structural connectivity and functional connectivity. The proposed framework effectively learns embeddings that preserve the similarity between brain networks, and demonstrates superior discriminative power in subject classification and visualization tasks.
Advances in graph signal processing for network neuroscience offer a unique pathway to integrate brain structure and function, with the goal of revealing some of the brain's organizing principles at the system level. In this direction, we develop a supervised graph representation learning framework to model the relationship between brain structural connectivity (SC) and functional connectivity (FC) via a graph encoder-decoder system. Specifically, we propose a Siamese network architecture equipped with graph convolutional encoders to learn graph (i.e., subject)-level embeddings that preserve application-dependent similarity measures between brain networks. This way, we effectively increase the number of training samples and bring in the flexibility to incorporate additional prior information via the prescribed target graph-level distance. While information on the brain structure-function coupling is implicitly distilled via reconstruction of brain FC from SC, our model also manages to learn representations that preserve the similarity between input graphs. The superior discriminative power of the learnt representations is demonstrated in downstream tasks including subject classification and visualization. All in all, this work advocates the prospect of leveraging learnt graph-level, similarity-preserving embeddings for brain network analysis, by bringing to bear standard tools of metric data analysis.
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