期刊
STEM CELLS INTERNATIONAL
卷 2016, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2016/2470351
关键词
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资金
- Nature Science Foundation of China [81271980, 81572164]
- National High-Tech R&D Program of China (863 Program) [2015AA020315]
- Key project of Logistics Research Plan of PLA [BWS13C014]
Chondrocytes communicate with each other mainly via diffusible signals rather than direct cell-to-cell contact. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is well regulated by the interactions of varieties of growth factors, cytokines, and signaling molecules. A number of critical signaling molecules have been identified to regulate the differentiation of chondrocyte from mesenchymal progenitor cells to their terminal maturation of hypertrophic chondrocytes, including bone morphogenetic proteins (BMPs), SRY-related high-mobility group-box gene 9 (Sox9), parathyroid hormone-related peptide (PTHrP), Indian hedgehog (Ihh), fibroblast growth factor receptor 3 (FGFR3), and beta-catenin. Except for these molecules, other factors such as adenosine, O-2 tension, and reactive oxygen species (ROS) also have a vital role in cartilage formation and chondrocytematuration. Here, we outlined the complex transcriptional network and the function of key factors in this network that determine and regulate the genetic program of chondrogenesis and chondrocyte differentiation.
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