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Robert Hooper et al.
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Hanene Zbidi et al.
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Bailong Xiao et al.
NATURE CHEMICAL BIOLOGY (2011)
Dendritic spine pathology in neuropsychiatric disorders
Peter Penzes et al.
NATURE NEUROSCIENCE (2011)
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Joanna Gruszczynska-Biegala et al.
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Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling
Marioly Mueller et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
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Kara McNair et al.
JOURNAL OF NEUROSCIENCE (2010)
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Janet E. McCombs et al.
MOLECULAR BIOSYSTEMS (2010)
A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells
Sonal Srikanth et al.
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Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons
King-Ho Cheung et al.
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D. Harshad Bhatt et al.
ANNUAL REVIEW OF PHYSIOLOGY (2009)
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Lukasz Bojarski et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
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Lucia Brunello et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
Development of a High-Throughput Assay for Screening of gamma-Secretase Inhibitor with Endogenous Human, Mouse or Drosophila gamma-Secretase
Lie-Feng Wang et al.
MOLECULES (2009)
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Charles R. Shideman et al.
NEUROSCIENCE LETTERS (2009)
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Tomasz Gwozdz et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)
Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2
Le Zheng et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
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Jose J. Lopez et al.
BIOCHEMICAL PHARMACOLOGY (2008)
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Ute Dreses-Werringloer et al.
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Alberto D.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2008)
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Kim N. Green et al.
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Laura Navarro-Borelly et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
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Lukasz Bojarski et al.
NEUROCHEMISTRY INTERNATIONAL (2008)
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King-Ho Cheung et al.
NEURON (2008)
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Ilya Bezprozvanny et al.
TRENDS IN NEUROSCIENCES (2008)
Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein
Ting Yang et al.
Molecular Brain (2008)
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Matthew L. Hemming et al.
PLOS BIOLOGY (2008)
STIM1 and the noncapacitative ARC channels
Trevor J. Shuttleworth et al.
CELL CALCIUM (2007)
Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion
Jen Liou et al.
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Boyan Fang et al.
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Huiping Tu et al.
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Jonathan Soboloff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels
Giancarlo Zatti et al.
CELL CALCIUM (2006)
Presenilin clinical mutations can affect γ-secretase activity by different mechanisms
M Bentahir et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Acute γ-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease
TA Comery et al.
JOURNAL OF NEUROSCIENCE (2005)
PixFRET, an ImageJ plug-in for FRET calculation that can accommodate variations in spectral bleed-throughs
JN Feige et al.
MICROSCOPY RESEARCH AND TECHNIQUE (2005)
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
J Liou et al.
CURRENT BIOLOGY (2005)
STIM1, an essential and conserved component of store-operated Ca2+ channel function
J Roos et al.
JOURNAL OF CELL BIOLOGY (2005)
Calcium dysregulation in Alzheimer's disease: Recent advances gained from genetically modified animals
IF Smith et al.
CELL CALCIUM (2005)
Presenilin regulates capacitative calcium entry dependently and independently of γ-secretase activity
Y Akbari et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Plasma Aβ40 and Aβ42 and Alzheimer's disease -: Relation to age, mortality, and risk
R Mayeux et al.
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WT Kimberly et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
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FM LaFerla
NATURE REVIEWS NEUROSCIENCE (2002)
Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes
ZP Xia et al.
BIOPHYSICAL JOURNAL (2001)
Regulation of dendritic spine morphology and synaptic function by Shank and Homer
C Sala et al.
NEURON (2001)
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NJ Emptage et al.
NEURON (2001)
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DJ Selkoe
NEUROLOGIC CLINICS (2000)
Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice
MA Leissring et al.
JOURNAL OF CELL BIOLOGY (2000)
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DM Skovronsky et al.
BIOCHEMISTRY (2000)
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AS Yoo et al.
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