期刊
出版社
SPIE-INT SOC OPTICAL ENGINEERING
DOI: 10.1117/12.2664219
关键词
Optical fibre; micro-endoscope; holographic endoscopy; etching; polishing; thin layer deposition
类别
资金
- BUT (KInG BUT) - OP RDE [CZ.02.2.69/0.0/0.0/19_073/0016948]
- European Research Council [724530]
- Ministry of Education, Youth and Sports of the Czech Republic [CZ.02.1.01/0.0/0.0/15 003/0000476]
- European Research Council (ERC) [724530] Funding Source: European Research Council (ERC)
Multiphoton microscopy allows tissue imaging with sub-cellular resolution at depths up to 1.5 mm. Optical relay elements called endoscopes are used to deliver light beyond this range. Minimally invasive endoscopy is achieved by focusing light through a step-index multimode optical fibre (MMF) using wave-front control. Fibre micro-endoscopes enable reaching any depth with minimal tissue disruption and maintaining resolution below 1 micron for in vivo microscopy. This study focuses on the impact of manufacturing methods on imaging quality of a custom-terminated multimode fibre probe.
Using multiphoton microscopy, we can image the tissue with sub-cellular resolution at depths down to 1.5 mm. Beyond this reach, the light must be delivered to the target region by optical relay elements inserted into the tissue - the endoscopes. Focusing light through a step-index multimode optical fibre (MMF) using wave-front control enables minimally-invasive endoscopy. With fibre micro-endoscopes, we can reach any depth with negligible tissue disruption and keep the resolution below 1 micrometre, sufficient for in vivo microscopy. We designed a novel custom-terminated multimode fibre probe. This work will focus on optical fibre probe manufacturing methods (etching, polishing and coating) and their impact on imaging quality.
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