Advanced strategies for constructing interfacial tissues of bone and tendon/ligament

Article Orthopedics

Pulsed electromagnetic field therapy alters early healing in a rat model of rotator cuff injury and repair: Potential mechanisms

Julianne Huegel et al.

Summary: This study found that PEMF treatment can improve the repair process of rat supraspinatus tendon injury through enhancing tendon healing signaling pathways, reducing inflammation, and promoting bone metabolism.

JOURNAL OF ORTHOPAEDIC RESEARCH (2022)

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Review Orthopedics

Augmentation of Rotator Cuff Healing With Orthobiologics

David Kovacevic et al.

Summary: The limited regenerative capacity of the tendon-bone enthesis after surgical repair presents a challenge to achieving desired clinical outcomes. Biologic augmentation methods show potential for improving the integrity of the enthesis, but there is currently no reliable method that consistently leads to clinical improvement.

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (2022)

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Article Pharmacology & Pharmacy

Uni-Directionally Oriented Fibro-Porous PLLA/Fibrin Bio-Hybrid Scaffold: Mechano-Morphological and Cell Studies

Andrew F. Uehlin et al.

Summary: In this study, a biohybrid fibrous scaffold based on nanofibers was developed and shown to have improved mechanical properties suitable for ligament-replacement grafts. The use of NaOH treatment and the immobilization of fibrin enhanced the osteogenic differentiation of cells, leading to potential applications in tissue engineering.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

Engineering an enthesis-like graft for rotator cuff repair: An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers

Can Chen et al.

Summary: An optimized decellularization approach was developed to fabricate a book-shaped decellularized enthesis matrix (O-BDEM), which was then combined with recombinant growth factors (CBP-GFs) tethered to the collagen of O-BDEM to create a novel scaffold (CBP-GFs/O-BDEM) for rotator cuff repair. The low immunogenicity of CBP-GEs/O-BDEM was confirmed in a mouse model, and the high regenerative potential of the engineered graft was demonstrated in a canine model. These findings highlight the potential of CBP-GEs/O-BDEM as an excellent scaffold for large/massive rotator cuff tear repair and provide new insights into interfacing tissue fabrication.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

In situ regeneration of bone-to-tendon structures: Comparisons between costal-cartilage derived stem cells and BMSCs in the rat model

Rui Zuo et al.

Summary: Stem cells from costal cartilage show potential for regeneration at the bone-tendon interface, with better adaptability and differentiation abilities compared to bone-marrow mesenchymal stem cells. These findings are significant for tissue engineering regeneration and clinical treatment of bone-tendon interface injuries.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

Driving native-like zonal enthesis formation in engineered ligaments using mechanical boundary conditions and β-tricalcium phosphate

M. Ethan Brown et al.

Summary: This study investigates the effect of compressive mechanical boundary conditions and the addition of beta-tricalcium phosphate (beta TCP) on the development of zonal ligament-to-bone entheses. The results show that compressive boundary clamps and beta TCP can guide ligament fibroblasts to produce zonal gradients in collagen organization, mineralization, and matrix composition, closely resembling immature ligament-to-bone attachments. This culture system provides a promising platform for understanding and promoting enthesis regeneration in graft repair and engineered replacements.

ACTA BIOMATERIALIA (2022)

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Article Orthopedics

Biomechanical properties of a suture anchor system from human allogenic mineralized cortical bone matrix for rotator cuff repair

Jakob E. Schanda et al.

Summary: This study aimed to investigate the biomechanical properties of an allogenic mineralized suture anchor (AMSA) and compare it with metallic suture anchor (MSA) and bioabsorbable suture anchor (BSA). The study found that AMSA showed promising initial fixation strength and could be considered as an alternative to MSA and BSA.

BMC MUSCULOSKELETAL DISORDERS (2022)

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Article Anatomy & Morphology

Effects of selective breeding for voluntary exercise, chronic exercise, and their interaction on muscle attachment site morphology in house mice

Alberto A. Castro et al.

Summary: The study found that chronic exercise can affect muscle attachment site morphology, but there is not always evolutionary coadaptation of muscle attachments with voluntary exercise behavior.

JOURNAL OF ANATOMY (2022)

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Article Orthopedics

Rotator cuff repair using a bioresorbable nanofiber interposition scaffold: a biomechanical and histologic analysis in sheep

Anthony Romeo et al.

Summary: This study evaluated the mechanical, structural, and histologic quality of rotator cuff repairs using an interposition nanofiber scaffold composed of polyglycolic acid-poly-L-lactide-co-epsilon-caprolactone in an acute sheep model. The results demonstrated that using the scaffold enhanced the repair strength and facilitated the formation of a tissue structure similar to the natural shoulder cuff attachment.

JOURNAL OF SHOULDER AND ELBOW SURGERY (2022)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cell Sheets for Engineering of the Tendon-Bone Interface

Lisa Berntsen et al.

Summary: This study demonstrates the potential of composite cell sheets, fabricated with adipose-derived stem cells, for engineering the tendon-bone interface. By stacking tenogenic and osteogenic cell sheets, the researchers were able to create a composite structure expressing markers of tendon, mineralized fibrocartilage, and bone. This research is an important step towards regenerating the biological gradient of the enthesis and has clinical translation implications.

TISSUE ENGINEERING PART A (2022)

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Article Cell & Tissue Engineering

Design-Build-Validate Strategy to 3D Print Bioglass Gradients for Anterior Cruciate Ligament Enthesis Reconstruction

Nilabh S. Kajave et al.

Summary: Rupture of the anterior cruciate ligament (ACL) is a common knee ligament injury. This study used a design-build-validate strategy combining 3D Raman spectral mapping and 3D printing to develop a tissue engineered scaffold that mimics the ACL bone-ligament interface. The scaffold showed potential for promoting interface regeneration and graft to bone integration.

TISSUE ENGINEERING PART C-METHODS (2022)

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Review Chemistry, Physical

Exploring the Mechanical Properties and Performance of Type-I Collagen at Various Length Scales: A Progress Report

Shirsha Bose et al.

Summary: This study provides a review of the mechanical properties of collagen, focusing on different hierarchical levels and long-term performance. The study also examines the influence of hydration on collagen mechanics and discusses the discrepancies between collagenous tissues (composed primarily of 20-30% collagen fibers) and pure collagen.

MATERIALS (2022)

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Article Cell Biology

Enthesis Healing Is Dependent on Scaffold Interphase Morphology-Results from a Rodent Patellar Model

Carlos J. Peniche Silva et al.

Summary: The study investigates the use of biphasic silk fibroin scaffolds for treating injured tendon-to-bone entheses. The results suggest that the design of the transition zone plays a crucial role in promoting healing of the injured enthesis.

CELLS (2022)

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Article Chemistry, Multidisciplinary

A reinforced nanofibrous patch with biomimetic mechanical properties and chondroinductive effect for rotator cuff tissue engineering

C. Chen et al.

Summary: The study developed PEEUU-GEL-KGN nanofibrous patches with biomimetic mechanical properties and enhanced tendon-bone healing effects, demonstrating outstanding biocompatibility and sustained release of KGN in vitro and in vivo.

MATERIALS TODAY CHEMISTRY (2022)

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Article Engineering, Biomedical

Shedding light on 3D printing: Printing photo-crosslinkable constructs for tissue engineering

Qiang Zhang et al.

Summary: This article provides an overview of recent advances in the promising development of photo-crosslinkable materials for 3D printing, with a focus on their biomedical applications for repairing damaged organs and developing in vitro tissue models. By selecting appropriate ink combinations or modulating the photo-crosslinking printing parameters, the structures and properties of the printed scaffolds can be finely tailored to meet practical application requirements.

BIOMATERIALS (2022)

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Article Biochemistry & Molecular Biology

Superior processability of Antheraea mylitta silk with cryo-milling: Performance in bone tissue regeneration

Nimisha Parekh et al.

Summary: A unique protocol for processing non-mulberry silk fiber has been developed, which reduces the beta sheet content and allows for the formation of completely dissolvable powder. These solutions can be used in conventional processing techniques to fabricate 3D scaffolds. In-vitro and in-vivo studies demonstrate that the processing technique does not affect the biocompatibility of the material and the AM scaffolds promote bone regeneration.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Materials Science, Characterization & Testing

Preparation of a robust silk fibroin scaffold with a reinforced concrete structure constructed with silk nanofibers as the skeleton based on a CaCl2-formic acid solution and freeze-drying method

Fei-Fan Shuang et al.

Summary: This study presents a robust silk fibroin (SF) scaffold with a reinforced concrete structure, where silk nanofibers serve as the skeleton. The scaffold is prepared using a CaCl2-formic acid dissolving system combined with freeze-drying method, ensuring minimal silk loss and shorter preparation time. Additionally, the scaffold retains the nanofibers of silk, preserving their mechanical toughness. The prepared scaffolds exhibit good biocompatibility and biodegradability. The findings provide a new strategy for manufacturing SF scaffolds and hold great potential for the development of silk fibroin materials in tissue engineering.

POLYMER TESTING (2022)

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Article Surgery

A prospective comparison of 3 hamstring ACL fixation devices-rigidfix, bioscrew, and intrafix-randomized into 4 groups with a minimum follow-up of 5 years

Leena Metso et al.

Summary: This study investigated the effectiveness of new fixation devices for ACL reconstruction at a five-year follow-up. The results showed no significant differences in clinical outcomes among the groups. However, patients using the Rigidfix cross-pin fixation device had a significantly higher rate of additional procedures compared to the other groups.

BMC SURGERY (2022)

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Article Chemistry, Multidisciplinary

ADSCs Promote Tenocyte Proliferation by Reducing the Methylation Level of lncRNA Morf4l1 in Tendon Injury

Haibo Zhao et al.

Summary: This study confirmed that adipose-derived mesenchymal stem cells (ADSCs) promoted tendon wound healing by reducing the methylation level of lncRNA Morf4l1.

FRONTIERS IN CHEMISTRY (2022)

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Article Materials Science, Biomaterials

Gradient Biomineralized Silk Fibroin Nanofibrous Scaffold with Osteochondral Inductivity for Integration of Tendon to Bone

Peixing Chen et al.

Summary: The study developed a nanofibrous scaffold based on SF and SBF, successfully mimicking the structure and properties of natural interface tissue, promoting the growth and differentiation of bone marrow mesenchymal stem cells, and improving the ultimate load and fibrocartilage-like tissue formation at the tendon-to-bone interface.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Engineering, Environmental

Gradient composite film with calcium phosphate silicate for improved tendon -to-Bone intergration

Wei Su et al.

Summary: This study fabricated gradient poly(e-caprolactone)/calcium phosphate silicate (G-P/C) composite films with varying P/C ratio, showing that higher levels of calcium phosphate silicate stimulated stronger osteogenic differentiation and mineralized matrix deposition. When interposed between the supraspinatus tendon and humerus bone, the G-P/C composite film group exhibited more tissue cellularity, better collagen alignment, better gradient mineralized cartilage formation, and gradient Ca distribution compared to other groups, suggesting its promising potential as a scaffold for tendon-to-bone interface engineering.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Endocrinology & Metabolism

The role of tendon derived stem/progenitor cells and extracellular matrix components in the bone tendon junction repair

Qin Shengnan et al.

Summary: The regeneration of fibrocartilage enthesis is crucial for the functional restoration of bone tendon junction. Biomimetic approaches, such as using decellularized ECM materials, show promise in providing scaffolds and microenvironments to guide stem cell differentiation towards chondrogenic commitment, thus facilitating fibrocartilage regeneration for better BTJ healing.

BONE (2021)

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Article Biochemistry & Molecular Biology

Light Cross-Linkable Marine Collagen for Coaxial Printing of a 3D Model of Neuromuscular Junction Formation

Borja Sanz et al.

Summary: Marine collagen, as an alternative source, shows potential in tissue engineering. The study revealed that marine collagen could serve as a low-cost, customizable, scalable, and quick-to-print platform for drug screening and researching neuromuscular junction physiology and pathogenesis.

BIOMEDICINES (2021)

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Article Orthopedics

Hierarchically Demineralized Cortical Bone Combined With Stem Cell-Derived Extracellular Matrix for Regeneration of the Tendon-Bone Interface

Shu-Kun He et al.

Summary: The study successfully promoted the repair of rotator cuff in a rabbit model by using hierarchically demineralized cortical bone (hDCB) coated with stem cell-derived extracellular matrix (hDCB-ECM), showing potential clinical applications.

AMERICAN JOURNAL OF SPORTS MEDICINE (2021)

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Article Orthopedics

Characterization of the distributions of collagen and PGs content in the decellularized book-shaped enthesis scaffolds by SR-FTIR

Qiang Shi et al.

Summary: The study successfully obtained decellularized book-shaped enthesis scaffolds from rabbit rotator cuff, evaluated the effect of decellularization on extracellular matrix structure through histological staining and SEM, and found that the content of collagen and PGs in the decellularized scaffolds decreased significantly. This innovative use of SR-FTIR can provide quantitative mapping of collagen and PGs distribution in enthesis scaffolds.

BMC MUSCULOSKELETAL DISORDERS (2021)

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Article Materials Science, Multidisciplinary

Application of a Hyperelastic 3D Printed Scaffold for Mesenchymal Stem Cell-Based Fabrication of a Bizonal Tendon Enthesis-like Construct

Riccardo Gottardi et al.

Summary: The study utilized hyperelastic biphasic 3D printed PLGA scaffolds to mimic the native insertion side, and cultured constructs in dual fluidic bioreactors to achieve regional differentiation towards tenogenic or chondrogenic fate. This system has been validated as a potential platform to form the tendon enthesis and will be further optimized for the fabrication of distinctly biphasic constructs in future studies.

FRONTIERS IN MATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Tissue Engineering for the Insertions of Tendons and Ligaments: An Overview of Electrospun Biomaterials and Structures

Alberto Sensini et al.

Summary: The musculoskeletal system is composed of hard and soft tissues with a wide range of mechanical properties. Interfacial tissue engineering aims to produce scaffolds with biomaterial gradients and mechanical properties to guide cell growth and differentiation. Electrospinning technique, due to its extreme versatility, has shown promise in generating polymeric nanofibers similar to musculoskeletal extracellular matrix, for the regeneration of complex tissues like the enthesis and myotendinous junctions.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Orthopedics

Effect of Exercise Intensity on the Healing of the Bone-Tendon Interface: A Mouse Rotator Cuff Injury Model Study

Huabin Chen et al.

Summary: In a mouse rotator cuff injury model, rehabilitation with increasing-intensity exercise was shown to promote BTI healing, with higher tissue fusion, more subchondral bone quantity, and increased expression of transcription factors.

AMERICAN JOURNAL OF SPORTS MEDICINE (2021)

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Article Orthopedics

Combined therapy of platelet-rich plasma and basic fibroblast growth factor using gelatin-hydrogel sheet for rotator cuff healing in rat models

Takeshi Kataoka et al.

Summary: The study showed that the combined therapy of basic fibroblast growth factor and platelet-rich plasma promoted angiogenesis, tendon maturation and fibrocartilage regeneration, enhancing mechanical strength. It was suggested that the combination of basic fibroblast growth factor and platelet-rich plasma might improve healing of both tendon and bone-tendon junction, and have a synergistic effect.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2021)

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Review Engineering, Biomedical

Applications of marine collagens in bone tissue engineering

Zhidong Lin et al.

Summary: Marine collagen has shown great promise as a biomaterial in bone tissue engineering, displaying excellent biological effects such as promoting osteogenesis, inhibiting inflammation, inducing cartilage differentiation, and improving bone mineral density. Its biocompatibility, biodegradability, ease of extractability, safety, low immunogenicity, and low production costs have made it a popular choice for researchers.

BIOMEDICAL MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Tendon tissue engineering: Cells, growth factors, scaffolds and production techniques

Sandra Ruiz-Alonso et al.

Summary: Tendon injuries are a global health issue that requires complex and long-lasting rehabilitation processes. Tissue engineering, an emerging discipline, offers new approaches to tackle tendon injuries. By analyzing the nature of tendons, traditional treatments, and various tissue engineering methods, personalized regeneration with better outcomes can be achieved.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Materials Science, Multidisciplinary

Multi-functionalized nanofibers with reactive oxygen species scavenging capability and fibrocartilage inductivity for tendon-bone integration

Peixing Chen et al.

Summary: A multifunctional silk fibroin nanofiber modified with polydopamine and kartogenin was designed and fabricated to reduce inflammation and enhance fibrocartilage formation, promoting enthesis healing. In vitro and in vivo studies confirmed the antioxidant capability and fibrochondral inductivity of the functionalized nanofibers, resulting in improved tendon-bone integration and accelerated interface tissue regeneration with excellent biomechanical properties. Incorporating antioxidant and bio-active molecules into extracellular matrix-like biomaterials in interface tissue engineering facilitates damaged tissue regeneration and functional recovery, improving the clinical outcome of engineered tissue.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

A Systematic Review of Tissue Engineering Scaffold in Tendon Bone Healing in vivo

Zimu Mao et al.

Summary: The use of tissue engineering scaffold, especially biomaterials, has shown significant effectiveness in tendon-bone healing and can be enhanced by biological interventions. Current research is mainly focused on animal models, calling for further clinical trials to explore the full potential of these approaches in clinical practice.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Review Astronomy & Astrophysics

Negative impact of disuse and unloading on tendon enthesis structure and function

S. Roffino et al.

Summary: This review focuses on the effects of chronic skeletal muscle disuse and unloading on muscle deconditioning, bone remodeling, and tendon enthesis. It explores the relationship between enthesis structure and mechanical stress, as well as the potential impact of spaceflight-induced enthesis remodeling on compressive strength and the risk of developing enthesopathies.

LIFE SCIENCES IN SPACE RESEARCH (2021)

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Article Medicine, General & Internal

Relationship between the suture materials used in extensor tendon injuries and reoperations

Melih Bagir et al.

Summary: The study found that the use of non-absorbable (polypropylene) sutures for extensor tendon repair increased the risk of suture-related reoperation, therefore suggesting that the use of absorbable (polydioxanone) sutures may be more appropriate.

CUKUROVA MEDICAL JOURNAL (2021)

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Article Engineering, Biomedical

Xenoextracellular matrix-rosiglitazone complex-mediated immune evasion promotes xenogenic bioengineered root regeneration by altering M1/M2 macrophage polarization

Tingting Lan et al.

Summary: The study demonstrates a robust strategy to load rosiglitazone (RSG) onto naturally sponge-like porous xenogenic extracellular matrix (xECM) scaffolds, activating peroxisome proliferators receptors-gamma (PPAR-gamma) to create an immunosuppressive environment for tissue reconstruction. This results in downregulation of proinflammatory macrophages and suppression of NF-kappa B expression, facilitating the regeneration of enthesis anchoring between the transplanted xenograft and host. The PPAR-gamma-NF-kappa B axis activated by the xECM-RSG complex can lead to conversion towards M2 macrophages with modest immunosuppressive capacity, promoting xECM-based tissue or organ regeneration.

BIOMATERIALS (2021)

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Review Clinical Neurology

Longitudinal atlantoaxial dislocation associated with type III odontoid fracture due to high-energy trauma. Case report and literature review

Juan F. Sanchez-Ortega et al.

Summary: Traumatic upper cervical spine injuries, especially involving atlantoaxial joint dislocation, are often caused by high-energy trauma and can result in severe neurological damage. Early immobilization and surgical intervention are crucial for these unstable cervical spine lesions, which have a high mortality rate.

SPINAL CORD SERIES AND CASES (2021)

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Review Chemistry, Applied

Extraction Methods, Characterization and Biomedical Applications of Collagen: a Review

Omar El Blidi et al.

Summary: Developing a standard extraction method for all types of collagen from different tissues is challenging due to their extreme diversity. Different methods have their pros and cons, and some have been optimized for easier extraction. Collagen plays a significant role in biomedical applications.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY (2021)

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Article Cell & Tissue Engineering

Producing Collagen Micro-stripes with Aligned Fibers for Cell Migration Assays

Danahe Mohammed et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2020)

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Article Orthopedics

Tendon and Ligament Healing and Current Approaches to Tendon and Ligament Regeneration

Natalie L. Leong et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2020)

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Article Engineering, Biomedical

In situ tissue engineering of the tendon-to-bone interface by endogenous stem/progenitor cells

Solaiman Tarafder et al.

BIOFABRICATION (2020)

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Review Biochemistry & Molecular Biology

The application of hyaluronic acid in bone regeneration

Peisong Zhai et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Engineering, Biomedical

Design and fabrication of clinoptilolite-nanohydroxyapatite/chitosan-gelatin composite scaffold and evaluation of its effects on bone tissue engineering

Ali Sadeghinia et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

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Article Biochemistry & Molecular Biology

Vascular endothelial growth factor enhances tendon-bone healing by activating Yes-associated protein for angiogenesis induction and rotator cuff reconstruction in rats

Yao Huang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Article Orthopedics

Rotator Cuff Repair With Autologous Tenocytes and Biodegradable Collagen Scaffold: A Histological and Biomechanical Study in Sheep

Bjoern P. Rossbach et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2020)

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Article Materials Science, Biomaterials

Collagen multifilament spinning

Robert Tonndorf et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Orthopedics

Three-dimensional printed multiphasic scaffolds with stratified cell-laden gelatin methacrylate hydrogels for biomimetic tendon-to-bone interface engineering

Yi Cao et al.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2020)

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Article Orthopedics

A 3-Dimensional Bioprinted Scaffold With Human Umbilical Cord Blood-Mesenchymal Stem Cells Improves Regeneration of Chronic Full-Thickness Rotator Cuff Tear in a Rabbit Model

Dong Rak Kwon et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2020)

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Article Orthopedics

A Synthetic Graft With Multilayered Co-Electrospinning Nanoscaffolds for Bridging Massive Rotator Cuff Tear in a Rat Model

Shuang Cong et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Sub- and Supramolecular X-Ray Characterization of Engineered Tissues from Equine Tendon, Bovine Dermis, and Fish Skin Type-I Collagen

Alberta Terzi et al.

MACROMOLECULAR BIOSCIENCE (2020)

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Article Engineering, Biomedical

Functional decellularized fibrocartilaginous matrix graft for rotator cuff enthesis regeneration: A novel technique to avoid in-vitro loading of cells

Can Chen et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Concurrent multi-lineage differentiation of mesenchymal stem cells through spatial presentation of growth factors

Amelia Hurley-Novatny et al.

BIOMEDICAL MATERIALS (2020)

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Article Materials Science, Biomaterials

Spatial Presentation of Tissue-Specific Extracellular Matrix Components along Electrospun Scaffolds for Tissue Engineering the Bone-Ligament Interface

Dinorath Olvera et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Article Multidisciplinary Sciences

Tough and tunable scaffold-hydrogel composite biomaterial for soft-to-hard musculoskeletal tissue interfaces

Raul A. Sun Han Chang et al.

SCIENCE ADVANCES (2020)

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Article Materials Science, Multidisciplinary

Treated dentin matrix-based scaffolds carrying TGF-β1/BMP4 for functional bio-root regeneration

Jie Chen et al.

APPLIED MATERIALS TODAY (2020)

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Article Medicine, Research & Experimental

Investigation of Hamstring Tendon Graft Fixation for the Reconstruction of Anterior Cruciate Ligament using Interference Screw Merely or in Combination with Supplementary Staple: A Clinical Trial

Sayed Hamid Mousavi et al.

ADVANCED BIOMEDICAL RESEARCH (2020)

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Article Oncology

Designing a novel vacuum aspiration system to decellularize large-size acellular enthesis with preservation of physicochemical and biological properties

Qiang Shi et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Article Orthopedics

Chitosan-Hydroxyapatite Scaffold for Tissue Engineering in Experimental Lumbar Laminectomy and Posterolateral Spinal Fusion in Wistar Rats

Martin Rodriguez-Vazquez et al.

ASIAN SPINE JOURNAL (2020)

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Article Biophysics

The bone-mimicking effect of calcium phosphate on composite chitosan scaffolds in maxillofacial bone tissue engineering

Supaporn Sangkert et al.

JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS (2020)

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Article Surgery

Novel Simple Strategy for Cartilage Tissue Engineering Using Stem Cells and Synthetic Polymer Scaffold

Uzdan Uz et al.

JOURNAL OF CRANIOFACIAL SURGERY (2019)

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Article Orthopedics

Overlay repair with a synthetic collagen scaffold improves the quality of healing in a rat rotator cuff repair model

Mark Zhu et al.

JOURNAL OF SHOULDER AND ELBOW SURGERY (2019)

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Review Medical Laboratory Technology

The cellular basis of fibrotic tendon healing: challenges and opportunities

Anne E. C. Nichols et al.

TRANSLATIONAL RESEARCH (2019)

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Article Engineering, Biomedical

Tendon Tissue Engineering: Effects of Mechanical and Biochemical Stimulation on Stem Cell Alignment on Cell-Laden Hydrogel Yarns

Chiara Rinoldi et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Orthopedics

Fibroblast Growth Factor 2 Enhances Tendon-to-Bone Healing in a Rat Rotator Cuff Repair of Chronic Tears

Ryuji Yonemitsu et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2019)

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Review Cell & Tissue Engineering

Tuning the biomimetic behavior of scaffolds for regenerative medicine through surface modifications

Nathan R. Richbourg et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

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Article Engineering, Biomedical

Oriented collagen fiber membranes formed through counter-rotating extrusion and their application in tendon regeneration

Shuang Yang et al.

BIOMATERIALS (2019)

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Article Nanoscience & Nanotechnology

In vitro behavior of tendon stem/progenitor cells on bioactive electrospun nanofiber membranes for tendon-bone tissue engineering applications

Yucheng Lin et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Review Chemistry, Physical

Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications

Sandra Pina et al.

MATERIALS (2019)

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Article Engineering, Biomedical

A Textile Platform Using Continuous Aligned and Textured Composite Microfibers to Engineer Tendon-to-Bone Interface Gradient Scaffolds

Isabel Calejo et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Endocrinology & Metabolism

Cytokine-Induced and Stretch-Induced Sphingosine 1-Phosphate Production by Enthesis Cells Could Favor Abnormal Ossification in Spondyloarthritis

Alaeddine El Jamal et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2019)

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Article Orthopedics

Open Reconstructive Strategies for Chronic Achilles Tendon Ruptures

Christopher Chen et al.

FOOT AND ANKLE CLINICS (2019)

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Article Engineering, Biomedical

Preparation of Decellularized Triphasic Hierarchical Bone-Fibrocartilage-Tendon Composite Extracellular Matrix for Enthesis Regeneration

Mingzhen Su et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Nanoscience & Nanotechnology

A LbL-Assembled Bioactive Coating Modified Nanofibrous Membrane for Rapid Tendon-Bone Healing in ACL Reconstruction

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Engineering, Biomedical

Tensile behavior and structural characterization of pig dermis

Andrei Pissarenko et al.

ACTA BIOMATERIALIA (2019)

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Article Engineering, Biomedical

Woven collagen biotextiles enable mechanically functional rotator cuff tendon regeneration during repair of segmental tendon defects in vivo

Greg D. Learn et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2019)

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Article Materials Science, Multidisciplinary

Surface functionalization of 3D printed polymer scaffolds to augment stem cell response

L. R. Jaidev et al.

MATERIALS & DESIGN (2019)

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Article Materials Science, Biomaterials

Pro-chondrogenic and immunomodulatory melatonin-loaded electrospun membranes for tendon-to-bone healing

Wei Song et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Article Engineering, Biomedical

Shear-induced alignment of collagen fibrils using 3D cell printing for corneal stroma tissue engineering

Hyeonji Kim et al.

BIOFABRICATION (2019)

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Article Engineering, Biomedical

Exploring the cell-protein-mineral interfaces: Interplay of silica (nano) rods@collagen biocomposites with human dermal fibroblasts

Yupeng Shi et al.

MATERIALS TODAY BIO (2019)

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Article Orthopedics

Patellar Tendon Reconstruction Using Hamstring Tendon and Adjustable Suspensory Cortical Fixation

Jordan Ovigue et al.

ARTHROSCOPY TECHNIQUES (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Anterolateral ligament injuries in knees with an anterior cruciate ligament tear: Contribution of ultrasonography and MRI

Marie Faruch Bilfeld et al.

EUROPEAN RADIOLOGY (2018)

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Article Nanoscience & Nanotechnology

Biomimetic Silk Scaffolds with an Amorphous Structure for Soft Tissue Engineering

Yonghuan Sang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Engineering, Biomedical

Heparin functionalization increases retention of TGF-beta 2 and GDF5 on biphasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineering

Sonia Font Tellado et al.

ACTA BIOMATERIALIA (2018)

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Review Pharmacology & Pharmacy

Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing

Magdalena Schneider et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Article Chemistry, Multidisciplinary

Design and Fabrication of a Hierarchically Structured Scaffold for Tendon-to-Bone Repair

Chunlei Zhu et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Citrate Improves Collagen Mineralization via Interface Wetting: A Physicochemical Understanding of Biomineralization Control

Changyu Shao et al.

ADVANCED MATERIALS (2018)

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Article Cell & Tissue Engineering

Novel engineered tendon-fibrocartilage-bone composite with cyclic tension for rotator cuff repair

Qian Liu et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

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Article Materials Science, Biomaterials

Growth factor-free salt-leached silk scaffolds for differentiating endothelial cells

Liying Xiao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Review Orthopedics

The roles of inflammatory mediators and immunocytes in tendinopathy

Chenqi Tang et al.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2018)

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Article Orthopedics

Bridging Repair of Large Rotator Cuff Tears Using a Multilayer Decellularized Tendon Slices Graft in a Rabbit Model

Guo-Ming Liu et al.

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2018)

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Article Polymer Science

Degradation and related changes in supermolecular structure of poly(caprolactone) in vivo conditions

P. Sajkiewicz et al.

POLYMER DEGRADATION AND STABILITY (2018)

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Article Sport Sciences

Localized BMP-4 release improves the enthesis of engineered bone-to-bone ligaments

A. Lee-Barthel et al.

TRANSLATIONAL SPORTS MEDICINE (2018)

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Article Orthopedics

Rotator cuff repair using cell sheets derived from human rotator cuff in a rat model

Yoshifumi Harada et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2017)

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Article Orthopedics

Pulsed Electromagnetic Field Therapy Improves Tendon-to-Bone Healing in a Rat Rotator Cuff Repair Model

Jennica J. Tucker et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2017)

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Article Orthopedics

Complete avulsion of the rotator cuff footprint in an irreducible traumatic posterior glenohumeral fracture-dislocation due to infraspinatus interposition

Ruben Scholten et al.

JOURNAL OF SHOULDER AND ELBOW SURGERY (2017)

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Article Materials Science, Biomaterials

Surface biofunctionalization of three-dimensional porous poly(lactic acid) scaffold using chitosan/OGP coating for bone tissue engineering

Sen Zeng et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Nanoscience & Nanotechnology

Electrospinning of aligned medical grade polyurethane nanofibres and evaluation of cell-scaffold interaction using SHED stem cells

Javad Yekrang et al.

MICRO & NANO LETTERS (2017)

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Article Orthopedics

The biology of rotator cuff healing

M. -A. Zumstein et al.

ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH (2017)

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Article Surgery

The Tissue-Engineered Tendon-Bone Interface: In Vitro and In Vivo Synergistic Effects of Adipose-Derived Stem Cells, Platelet-Rich Plasma, and Extracellular Matrix Hydrogel

Rory McGoldrick et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2017)

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Article Cell & Tissue Engineering

An Engineered Multiphase Three-Dimensional Microenvironment to Ensure the Controlled Delivery of Cyclic Strain and Human Growth Differentiation Factor 5 for the Tenogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells

Marco Govoni et al.

TISSUE ENGINEERING PART A (2017)

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Article Cell & Tissue Engineering

Collagen Cross-Linking: Biophysical, Biochemical, and Biological Response Analysis

Luis M. Delgado et al.

TISSUE ENGINEERING PART A (2017)

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Article Engineering, Biomedical

Freeze-Drying as a Novel Biofabrication Method for Achieving a Controlled Microarchitecture within Large, Complex Natural Biomaterial Scaffolds

Claire M. Brougham et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Article Multidisciplinary Sciences

Efficient decellularization for tissue engineering of the tendon-bone interface with preservation of biomechanics

Kai Xu et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing

Kristen Howell et al.

SCIENTIFIC REPORTS (2017)

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Review Pharmacology & Pharmacy

From Tendon Injury to Collagen-based Tendon Regeneration: Overview and Recent Advances

Clement Rieu et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

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Article Orthopedics

Surgical Treatment of Distal Biceps Tendon Ruptures: An Analysis of Complications in 784 Surgical Repairs

Taylor R. Dunphy et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2017)

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Article Engineering, Biomedical

Flexible bipolar nanofibrous membranes for improving gradient microstructure in tendon-to-bone healing

Xiaoxi Li et al.

ACTA BIOMATERIALIA (2017)

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Article Chemistry, Multidisciplinary

Optimization of Glutaraldehyde Vapor Treatment for Electrospun Collagen/Silk Tissue Engineering Scaffolds

Bofan Zhu et al.

ACS OMEGA (2017)

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Article Engineering, Biomedical

A micro-architecturally biomimetic collagen template for mesenchymal condensation based cartilage regeneration

Mousa Younesi et al.

ACTA BIOMATERIALIA (2016)

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Article Orthopedics

Incidence of Anterior Cruciate Ligament Tears and Reconstruction: A 21-Year Population-Based Study

Thomas L. Sanders et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2016)

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Article Biochemistry & Molecular Biology

Amorphous Silk Nanofiber Solutions for Fabricating Silk-Based Functional Materials

Xiaodan Dong et al.

BIOMACROMOLECULES (2016)

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Article Engineering, Biomedical

High-purity magnesium interference screws promote fibrocartilaginous entheses regeneration in the anterior cruciate ligament reconstruction rabbit model via accumulation of BMP-2 and VEGF

Pengfei Cheng et al.

BIOMATERIALS (2016)

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Article Orthopedics

Augmentation and repair of tendons using demineralised cortical bone

Sherif Elnikety et al.

BMC MUSCULOSKELETAL DISORDERS (2016)

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Article Biochemistry & Molecular Biology

Fabrication of duck's feet collagen-silk hybrid biomaterial for tissue engineering

Soo Hyeon Kim et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)

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Article Orthopedics

Association of synovial inflammation and inflammatory mediators with glenohumeral rotator cuff pathology

Geoffrey D. Abrams et al.

JOURNAL OF SHOULDER AND ELBOW SURGERY (2016)

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Article Orthopedics

Rare ACL enthesis tears treated by suture in children. A report of 14 cases after a mean 15 years follow-up

P. -M. Xavier et al.

ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH (2016)

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Article Multidisciplinary Sciences

A biofidelic 3D culture model to study the development of brain cellular systems

M. Ren et al.

SCIENTIFIC REPORTS (2016)

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Article Materials Science, Multidisciplinary

Fabrication and characterization of elastic hollow nanofibrous PU yarn

S. J. Najafi et al.

MATERIALS & DESIGN (2016)

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Article Cell & Tissue Engineering

Preferential tendon stem cell response to growth factor supplementation

Carolyn Holladay et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2016)

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Article Orthopedics

Multilayer scaffolds in orthopaedic tissue engineering

Kivanc Atesok et al.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2016)

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Article Engineering, Biomedical

Triphasic scaffolds for the regeneration of the bone-ligament interface

G. Criscenti et al.

BIOFABRICATION (2016)

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Article Engineering, Biomedical

Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: In vitro and in vivo assessment of biological performance

Le-Ping Yan et al.

ACTA BIOMATERIALIA (2015)

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Review Pharmacology & Pharmacy

The past, present and future in scaffold-based tendon treatments

A. J. Lomas et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

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Review Pharmacology & Pharmacy

Biologics for tendon repair

Denitsa Docheva et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

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Review Radiology, Nuclear Medicine & Medical Imaging

Calcaneal Avulsion Fractures: An Often Forgotten Diagnosis

Sarah M. Yu et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2015)

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Article Endocrinology & Metabolism

Quantifying the osteocyte network in the human skeleton

Pascal R. Buenzli et al.

BONE (2015)

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Article Biophysics

Evaluation of biodegradable elastic scaffolds made of anionic polyurethane for cartilage tissue engineering

Meng-Chao Tsai et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2015)

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Review Geriatrics & Gerontology

Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review

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GERONTOLOGY (2015)

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Review Biochemistry & Molecular Biology

Collagen based polyurethanes-A review of recent advances and perspective

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

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Article Orthopedics

Cyclic mechanical stimulation rescues achilles tendon from degeneration in a bioreactor system

Tao Wang et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2015)

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Article Multidisciplinary Sciences

Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using Silk-Collagen Scaffold and Comparison with Autograft

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PLOS ONE (2015)

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Article Toxicology

Poly(L-lactic acid) membranes: Absence of genotoxic hazard and potential for drug delivery

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TOXICOLOGY LETTERS (2015)

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Editorial Material Engineering, Biomedical

Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for Osteotendinous Junction Engineering

Steven R. Caliari et al.

ADVANCED HEALTHCARE MATERIALS (2015)

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Article Polymer Science

Investigations on the Structural and Mechanical Properties of Polyurethane Resins Based on Cu(II)phthalocyanines

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INTERNATIONAL JOURNAL OF POLYMER SCIENCE (2015)

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Article Cell Biology

Alternative protocols to induce chondrogenic differentiation: transforming growth factor-β superfamily

Claudia Cicione et al.

CELL AND TISSUE BANKING (2015)

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Article Orthopedics

rhPDGF-BB Promotes Early Healing in a Rat Rotator Cuff Repair Model

David Kovacevic et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2015)

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Article Orthopedics

Transcription Factor Mohawk Controls Tenogenic Differentiation of Bone Marrow Mesenchymal Stem Cells In Vitro and In Vivo

Koji Otabe et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2015)

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Article Engineering, Biomedical

A 3D bioprinted complex structure for engineering the muscle-tendon unit

Tyler K. Merceron et al.

BIOFABRICATION (2015)

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Article Nanoscience & Nanotechnology

Nanofiber Scaffolds with Gradients in Mineral Content for Spatial Control of Osteogenesis

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ACS APPLIED MATERIALS & INTERFACES (2014)

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Article Engineering, Biomedical

Woven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissues

F. Han et al.

ACTA BIOMATERIALIA (2014)

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Article Engineering, Biomedical

Platelet-derived growth-factor-releasing aligned collagen-nanoparticle fibers promote the proliferation and tenogenic differentiation of adipose-derived stem cells

XingGuo Cheng et al.

ACTA BIOMATERIALIA (2014)

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Article Chemistry, Multidisciplinary

Tenogenic Induction of Human MSCs by Anisotropically Aligned Collagen Biotextiles

Mousa Younesi et al.

ADVANCED FUNCTIONAL MATERIALS (2014)

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Article Biochemistry & Molecular Biology

Overexpression of TGF-β1 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cells

Yong Il Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

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Article Orthopedics

Biomechanical examination of patellar tendon ruptures repaired with a tendon graft: an experimental study

Ilker Karahasanoglu et al.

EKLEM HASTALIKLARI VE CERRAHISI-JOINT DISEASES AND RELATED SURGERY (2014)

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Article Engineering, Biomedical

Nanomechanical assessment of human and murine collagen fibrils via atomic force microscopy cantilever-based nanoindentation

Orestis G. Andriotis et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2014)

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Article Multidisciplinary Sciences

Fetal and adult fibroblasts display intrinsic differences in tendon tissue engineering and regeneration

Qiao-Mei Tang et al.

SCIENTIFIC REPORTS (2014)

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Review Cell & Tissue Engineering

Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models

Sunny Akogwu Abbah et al.

STEM CELL RESEARCH & THERAPY (2014)

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Article Cell & Tissue Engineering

Co-cultured tissue-specific scaffolds for tendon/bone interface engineering

Jared O. Cooper et al.

JOURNAL OF TISSUE ENGINEERING (2014)

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Review Cell & Tissue Engineering

A review on the use of cell therapy in the treatment of tendon disease and injuries

Jasmine O. Y. Ho et al.

JOURNAL OF TISSUE ENGINEERING (2014)

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Article Surgery

Preliminary Report of In Vitro Reconstruction of a Vascularized Tendonlike Structure A Novel Application for Adipose-Derived Stem Cells

Vincenzo Vindigni et al.

ANNALS OF PLASTIC SURGERY (2013)

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Article Engineering, Biomedical

Functional Attachment of Soft Tissues to Bone: Development, Healing, and Tissue Engineering

Helen H. Lu et al.

Annual Review of Biomedical Engineering (2013)

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Article Biotechnology & Applied Microbiology

Programmable mechanical stimulation influences tendon homeostasis in a bioreactor system

Tao Wang et al.

BIOTECHNOLOGY AND BIOENGINEERING (2013)

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Article Biochemistry & Molecular Biology

Properties and modification of porous 3-D collagen/hydroxyapatite composites

A. Sionkowska et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2013)

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Article Engineering, Biomedical

Nanofiber scaffold gradients for interfacial tissue engineering

Murugan Ramalingam et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2013)

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Article Biophysics

Tendon glycosaminoglycan proteoglycan sidechains promote collagen fibril sliding-AFM observations at the nanoscale

S. Rigozzi et al.

JOURNAL OF BIOMECHANICS (2013)

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Article Engineering, Environmental

Effects of Wood Fiber and Microclay on the Performance of Soy Based Polyurethane Foams

Ruijun Gu et al.

JOURNAL OF POLYMERS AND THE ENVIRONMENT (2013)

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Article Multidisciplinary Sciences

Quantitative Mapping of Matrix Content and Distribution across the Ligament-to-Bone Insertion

Jeffrey P. Spalazzi et al.

PLOS ONE (2013)

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Article Biotechnology & Applied Microbiology

Skeletal Muscle Regeneration on Protein-Grafted and Microchannel-Patterned Scaffold for Hypopharyngeal Tissue Engineering

Zhisen Shen et al.

BIOMED RESEARCH INTERNATIONAL (2013)

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Article Engineering, Biomedical

Response of bone marrow stromal cells to graded co-electrospun scaffolds and its implications for engineering the ligament-bone interface

Satyavrata Samavedi et al.

BIOMATERIALS (2012)

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Article Engineering, Biomedical

Tenogenic differentiation of human MSCs induced by the topography of electrochemically aligned collagen threads

Vipuil Kishore et al.

BIOMATERIALS (2012)

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Article Cell & Tissue Engineering

Allogenous Tendon Stem/Progenitor Cells in Silk Scaffold for Functional Shoulder Repair

Weiliang Shen et al.

CELL TRANSPLANTATION (2012)

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Review Cell Biology

Tissue-Engineering Strategies for the Tendon/Ligament-to-Bone Insertion

Lester Smith et al.

CONNECTIVE TISSUE RESEARCH (2012)

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Article Multidisciplinary Sciences

Bone Marrow-Derived Matrix Metalloproteinase-9 Is Associated with Fibrous Adhesion Formation after Murine Flexor Tendon Injury

Alayna E. Loiselle et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation

Suwimon Boonrungsiman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Review Cell & Tissue Engineering

Mechanical Stretching for Tissue Engineering: Two-Dimensional and Three-Dimensional Constructs

Brandon D. Riehl et al.

TISSUE ENGINEERING PART B-REVIEWS (2012)

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Review Engineering, Biomedical

Silk Fibroin in Tissue Engineering

Naresh Kasoju et al.

ADVANCED HEALTHCARE MATERIALS (2012)

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Article Cell & Tissue Engineering

Chronological changes in the collagen-type composition at tendon-bone interface in rabbits

K. Tabuchi et al.

BONE & JOINT RESEARCH (2012)

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Article Engineering, Biomedical

Fabrication of a model continuously graded co-electrospun mesh for regeneration of the ligament-bone interface

Satyavrata Samavedi et al.

ACTA BIOMATERIALIA (2011)

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Article Orthopedics

Calcium-Phosphate Matrix With or Without TGF-β3 Improves Tendon-Bone Healing After Rotator Cuff Repair

David Kovacevic et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2011)

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Article Anatomy & Morphology

Characterization of the Anchoring Morphology and Mineral Content of the Anterior Cruciate and Medial Collateral Ligaments of the Knee

Kristofer D. Sinclair et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2011)

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Article Biochemistry & Molecular Biology

Regulation of Silk Material Structure by Temperature-Controlled Water Vapor Annealing

Xiao Hu et al.

BIOMACROMOLECULES (2011)

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Article Engineering, Biomedical

Biodegradation and in vivo biocompatibility of a degradable, polar/hydrophobic/ionic polyurethane for tissue engineering applications

Joanne E. McBane et al.

BIOMATERIALS (2011)

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Article Biotechnology & Applied Microbiology

Fabrication of three-dimensional collagen scaffold using an inverse mould-leaching process

SeungHyun Ahn et al.

BIOPROCESS AND BIOSYSTEMS ENGINEERING (2011)

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Review Biotechnology & Applied Microbiology

Lactic acid production from lignocellulose-derived sugars using lactic acid bacteria: Overview and limits

Mohamed Ali Abdel-Rahman et al.

JOURNAL OF BIOTECHNOLOGY (2011)

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Review Polymer Science

Biomedical Applications of Biodegradable Polymers

Bret D. Ulery et al.

JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS (2011)

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Article Orthopedics

Rotator cuff repair augmentation using a novel polycarbonate polyurethane patch: preliminary results at 12 months' follow-up

Ivan Encalada-Diaz et al.

JOURNAL OF SHOULDER AND ELBOW SURGERY (2011)

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Article Chemistry, Multidisciplinary

Hierarchical Structure and Nanomechanics of Collagen Microfibrils from the Atomistic Scale Up

Alfonso Gautieri et al.

NANO LETTERS (2011)

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Article Medicine, Research & Experimental

Evaluation of Collagen Gel Microstructure by Scanning Electron Microscopy

A. G. Pogorelov et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2010)

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Article Chemistry, Multidisciplinary

D-(-)-Lactic acid production from cellobiose and cellulose by Lactobacillus lactis mutant RM2-24

Mamta Singhvi et al.

GREEN CHEMISTRY (2010)

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Article Biophysics

Micromechanical models of helical superstructures in ligament and tendon fibers predict large Poisson's ratios

Shawn P. Reese et al.

JOURNAL OF BIOMECHANICS (2010)

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Editorial Material Cell Biology

Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in?

Amnon Buxboim et al.

JOURNAL OF CELL SCIENCE (2010)

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Article Biochemistry & Molecular Biology

Reinforcing Silk Scaffolds with Silk Particles

Rangam Rajkhowa et al.

MACROMOLECULAR BIOSCIENCE (2010)

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Article Multidisciplinary Sciences

Mesenchymal Stem Cell Therapy Regenerates the Native Bone-Tendon Junction after Surgical Repair in a Degenerative Rat Model

Geoffroy Nourissat et al.

PLOS ONE (2010)

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Article Cell & Tissue Engineering

Novel Freeze-Drying Methods to Produce a Range of Collagen-Glycosaminoglycan Scaffolds with Tailored Mean Pore Sizes

Matthew G. Haugh et al.

TISSUE ENGINEERING PART C-METHODS (2010)

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Article Orthopedics

Collagen-Platelet Composites Improve the Biomechanical Properties of Healing Anterior Cruciate Ligament Grafts in a Porcine Model

Braden C. Fleming et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2009)

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Review Biochemistry & Molecular Biology

From mechanotransduction to extracellular matrix gene expression in fibroblasts

Matthias Chiquet et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)

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Article Engineering, Biomedical

Engineering human neo-tendon tissue in vitro with human dermal fibroblasts under static mechanical strain

Dan Deng et al.

BIOMATERIALS (2009)

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Article Engineering, Biomedical

Tissue Engineering of the Anterior Cruciate Ligament: The Viscoelastic Behavior and Cell Viability of a Novel Braid-Twist Scaffold

Joseph W. Freeman et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2009)

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Review Biophysics

Development of ligament tissue biodegradable devices: A review

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Article Orthopedics

Tendon re-attachment to metal prostheses in an in vivo animal model using demineralised bone matrix

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JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME (2009)

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Article Surgery

Mechanical Design Optimization of Bioabsorbable Fixation Devices for Bone Fractures

Scott T. Lovald et al.

JOURNAL OF CRANIOFACIAL SURGERY (2009)

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Article Chemistry, Multidisciplinary

Nanofiber Scaffolds with Gradations in Mineral Content for Mimicking the Tendon-to-Bone Insertion Site

Xiaoran Li et al.

NANO LETTERS (2009)

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Article Orthopedics

Fibroma of tendon sheath located within the ankle joint capsule

Riccardo Ciatti et al.

JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY (2009)

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Article Engineering, Biomedical

Engineering of extensor tendon complex by an ex vivo approach

Bin Wang et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

An electrochemical fabrication process for the assembly of anisotropically oriented collagen bundles

Xingguo Cheng et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

Functionally graded electrospun polycaprolactone and β-tricalcium phosphate nanocomposites for tissue engineering applications

Cevat Erisken et al.

BIOMATERIALS (2008)

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Article Engineering, Biomedical

In vivo degradation of three-dimensional silk fibroin scaffolds

Yongzhong Wang et al.

BIOMATERIALS (2008)

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Article Biochemistry & Molecular Biology

Interactive effects of growth factors and three-dimensional scaffolds on multipotent mesenchymal stromal cells

Leslie Heckmann et al.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2008)

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Article Engineering, Biomedical

Processing nanoengineered scaffolds through electrospinning and mineralization, suitable for biomimetic bone tissue engineering

Susan Liao et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2008)

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Article Multidisciplinary Sciences

Characterization of the structure-function relationship at the ligament-to-bone interface

Kristen L. Moffat et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

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Article Orthopedics

Generation of tendon-to-bone interface Enthesis with use of recombinant BMP-2 in a rabbit model

Yusuke Hashimoto et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2007)

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Review Cell & Tissue Engineering

Review: Photopolymerizable and degradable biomaterials for tissue engineering applications

Jamie L. Ifkovits et al.

TISSUE ENGINEERING (2007)

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Review Sport Sciences

Eccentric overload training in patients with chronic Achilles tendinopathy: a systematic review

J. J. Kingma et al.

BRITISH JOURNAL OF SPORTS MEDICINE (2007)

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Article Engineering, Chemical

Economic evaluation of an integrated process for lactic acid production from ultrafiltered whey

M. I. Gonzalez et al.

JOURNAL OF FOOD ENGINEERING (2007)

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Article Chemistry, Multidisciplinary

Lactic acid production from waste sugarcane bagasse derived cellulose

Mukund G. Adsul et al.

GREEN CHEMISTRY (2007)

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Article Critical Care Medicine

Tendon injuries across the world: Treatment

Jin Bo Tang

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2006)

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Article Materials Science, Coatings & Films

PLLA scaffolds with biomimetic apatite coating and biomimetic apatite/collagen composite coating to enhance osteoblast-like cells attachment and activity

Yun Chen et al.

SURFACE & COATINGS TECHNOLOGY (2006)

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Article Orthopedics

Elastographic imaging of strain distribution in the anterior cruciate ligament and at the ligament-bone insertions

Jeffrey P. Spalazzi et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2006)

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Article Orthopedics

Age-dependent changes in matrix composition and organization at the ligament-to-bone insertion

I-Ning E. Wang et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2006)

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Review Biotechnology & Applied Microbiology

Lactic acid: recent advances in products, processes and technologies - a review

Rathin Datta et al.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2006)

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Article Biotechnology & Applied Microbiology

Fermentation of 12% (w/v) glucose to 1.2 M lactate by Escherichia coli strain SZ194 using mineral salts medium

S Zhou et al.

BIOTECHNOLOGY LETTERS (2006)

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Review Orthopedics

Tissue engineering for anterior cruciate ligament reconstruction: A review of current strategies

FA Petrigliano et al.

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2006)

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Article Rheumatology

Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy

AN Corps et al.

RHEUMATOLOGY (2006)

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Article Biophysics

Cyclic strain increases fibroblast proliferation, matrix accumulation, and elastic modulus of fibroblast-seeded polyurethane constructs

K Webb et al.

JOURNAL OF BIOMECHANICS (2006)

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Article Rheumatology

Enthesis as a target element in spondylarthritides

J. L. Fernandez-Sueiro

REUMATOLOGIA CLINICA (2006)

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Review Biology

Lactate - a signal coordinating cell and systemic function

A Philp et al.

JOURNAL OF EXPERIMENTAL BIOLOGY (2005)

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Article Engineering, Biomedical

Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin

UJ Kim et al.

BIOMATERIALS (2005)

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Review Biochemistry & Molecular Biology

An overview of polylactides as packaging materials

R Auras et al.

MACROMOLECULAR BIOSCIENCE (2004)

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Article Rheumatology

Versican splice variant messenger RNA expression in normal human Achilles tendon and tendinopathies

AN Corps et al.

RHEUMATOLOGY (2004)

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Article Polymer Science

Structure and morphology of electrospun silk nanofibers

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POLYMER (2004)

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Article Engineering, Biomedical

Regenerative versus reparative healing in tendon: A study of biomechanical and histological properties in fetal sheep

PK Beredjiklian et al.

ANNALS OF BIOMEDICAL ENGINEERING (2003)

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Article Biochemistry & Molecular Biology

Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan

C Wiberg et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Orthopedics

Repair of patellar tendon injuries using a cell-collagen composite

HA Awad et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2003)

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Article Engineering, Biomedical

Silk-based biomaterials

GH Altman et al.

BIOMATERIALS (2003)

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Article Orthopedics

Functional morphology of the supraspinatus tendon

J Fallon et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2002)

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Article Orthopedics

Avulsion fractures of both anterior and posterior cruciate ligament tibial insertions

OU Calpur et al.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2002)

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Article Orthopedics

Tendon healing in a bone tunnel.: Part II:: Histologic analysis after biodegradable interference fit fixation in a model of anterior cruciate ligament reconstruction in sheep

A Weiler et al.

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY (2002)

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Cell differentiation by mechanical stress

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FASEB JOURNAL (2001)

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Association of chondroadherin with collagen type II

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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Structure of the tendon connective tissue

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SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS (2000)

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Review Biotechnology & Applied Microbiology

Factors affecting the fermentative lactic acid production from renewable resources

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ENZYME AND MICROBIAL TECHNOLOGY (2000)

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Advanced strategies for constructing interfacial tissues of bone and tendon/ligament

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