期刊
PATHOGENS AND DISEASE
卷 74, 期 5, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femspd/ftw051
关键词
microbiota; pathogens; metabolites; signaling; virulence; competition
资金
- National Institutes of Health, National Institute of Allergy and Infectious Diseases [AI118732]
- NIH [5T32AI007046]
The gut microbiota plays essential roles in human health and disease. In this review, we focus on the role of the intestinal microbiota in promoting resistance to infection by bacterial pathogens as well as how pathogens overcome this barrier. We discuss how the resident microbiota restricts growth and colonization of invading pathogens by limiting availability of nutrients and through generation of a hostile environment. Additionally, we examine how microbiota-derived signaling molecules interfere with bacterial virulence. In turn, we discuss how pathogens exploit non-competitive metabolites to replicate in vivo as well as to precisely control virulence and cause disease. This bacterial two step of creating and overcoming challenges important in preventing and establishing infection highlights the complexities of elucidating interactions between the commensal bacteria and pathogens. Better understanding of microbiota-pathogen interplay will have significant implications for developing novel therapeutics to treat infectious diseases.
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